PDB: 185519 件ウェブページステータス検索Chemie searchBIRD

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6R0H	Glycogen Phosphorylase b in complex with 3 分子名称: 3-(4-fluorophenyl)-~{N}-[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]benzamide, Glycogen phosphorylase, muscle form, ... 著者 Tsagkarakou, S.A, Koulas, M.S, Kyriakis, E, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D. 登録日 2019-03-13 公開日 2019-04-10 最終更新日 2019-04-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-beta-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors. Molecules, 24, 2019
6R0I	Glycogen Phosphorylase b in complex with 4 分子名称: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Koulas, M.S, Tsagkarakou, S.A, Kyriakis, E, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D. 登録日 2019-03-13 公開日 2019-04-17 最終更新日 2019-04-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-beta-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors. Molecules, 24, 2019
2ISV	Structure of Giardia fructose-1,6-biphosphate aldolase in complex with phosphoglycolohydroxamate 分子名称: PHOSPHOGLYCOLOHYDROXAMIC ACID, Putative fructose-1,6-bisphosphate aldolase, ZINC ION 著者 Galkin, A, Herzberg, O. 登録日 2006-10-18 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia. J.Biol.Chem., 282, 2007
6QW3	Calcium-bound gelsolin domain 2 分子名称: CALCIUM ION, Gelsolin 著者 Scalone, E, Boni, F, Milani, M, Mastrangelo, E, de Rosa, M. 登録日 2019-03-05 公開日 2019-08-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion. Biochem.Biophys.Res.Commun., 518, 2019
4DUZ	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U13C, bound with streptomycin 分子名称: 16S rRNA, MAGNESIUM ION, STREPTOMYCIN, ... 著者 Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. 登録日 2012-02-22 公開日 2013-02-27 実験手法 X-RAY DIFFRACTION (3.651 Å) 主引用文献 A structural basis for streptomycin resistance To be Published
5N0Y	hPAD4 crystal complex with AFM-30a 分子名称: CALCIUM ION, Protein-arginine deiminase type-4, SULFATE ION, ... 著者 Beaumont, E, Kerry, P, Thompson, P, Muth, A, Subramanian, V, Nagar, M, Srinath, H, Clancy, K, Parelkar, S. 登録日 2017-02-03 公開日 2017-05-24 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J. Med. Chem., 60, 2017
5CEI	Crystal structure of CDK8:Cyclin C complex with compound 22 分子名称: 1,2-ETHANEDIOL, 4-(4-iodophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide, Cyclin-C, ... 著者 Kiefer, J.R, Schneider, E.V, Maskos, K, Koehler, M.F.T. 登録日 2015-07-06 公開日 2016-02-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. Acs Med.Chem.Lett., 7, 2016
1LCF	CRYSTAL STRUCTURE OF COPPER-AND OXALATE-SUBSTITUTED HUMAN LACTOFERRIN AT 2.0 ANGSTROMS RESOLUTION 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, COPPER (II) ION, ... 著者 Smith, C.A, Anderson, B.F, Baker, H.M, Baker, E.N. 登録日 1994-01-11 公開日 1994-08-31 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of copper- and oxalate-substituted human lactoferrin at 2.0 A resolution. Acta Crystallogr.,Sect.D, 50, 1994
5KE2	Crystal structure of SETDB1 Tudor domain in complex with inhibitor XST06472A 分子名称: (3~{S})-~{N}-~{tert}-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ... 著者 Dong, A, Iqbal, A, Mader, P, Dobrovetsky, E, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2016-06-09 公開日 2016-07-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Crystal structure of SETDB1 Tudor domain in complex with inhibitor xst06472a to be published
5G6U	Crystal structure of langerin carbohydrate recognition domain with GlcNS6S 分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Porkolab, V, Chabrol, E, Varga, N, Ordanini, S, Sutkeviciute, I, Thepaut, M, Bernardi, A, Fieschi, F. 登録日 2016-07-21 公開日 2018-02-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.844 Å) 主引用文献 Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition. ACS Chem. Biol., 13, 2018
6QZ7	Structure of MBP-Mcl-1 in complex with compound 8b 分子名称: (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, SODIUM ION, ... 著者 Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A. 登録日 2019-03-11 公開日 2019-08-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J.Med.Chem., 62, 2019
5XI1	Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs) 分子名称: 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, RNA (5'-R(P*CP*CP*GP*CP*AP*GP*CP*GP*G)-3') 著者 Tawani, A, Mishra, S.K, Khan, E, Kumar, A. 登録日 2017-04-25 公開日 2018-08-08 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs). ACS Chem. Biol., 13, 2018
2PBJ	GSH-heme bound microsomal prostaglandin E synthase 分子名称: CHLORIDE ION, GLUTATHIONE, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Takusagawa, F, Yamada, T. 登録日 2007-03-28 公開日 2008-02-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme. Biochemistry, 46, 2007
5XER	TK9 NMR structure in DPC micelle 分子名称: THR-VAL-TYR-VAL-TYR-SER-ARG-VAL-LYS 著者 Ghosh, A, Bhunia, A. 登録日 2017-04-05 公開日 2018-04-18 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study. Biochim Biophys Acta Biomembr, 1860, 2018
6QWG	Serial Femtosecond Crystallography Structure of Cu Nitrite Reductase from Achromobacter cycloclastes: Nitrite complex at Room Temperature 分子名称: COPPER (II) ION, Copper-containing nitrite reductase, NITRITE ION 著者 Ebrahim, A.E, Moreno-Chicano, T, Appleby, M.V, Worrall, J.W, Duyvesteyn, H.M.E, Strange, R.W, Beale, J, Axford, D, Sherrell, D.A, Sugimoto, H, Owada, S, Tono, K, Owen, R.L. 登録日 2019-03-05 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 High-throughput structures of protein-ligand complexes at room temperature using serial femtosecond crystallography. Iucrj, 6, 2019
3OPY	Crystal structure of Pichia pastoris phosphofructokinase in the T-state 分子名称: 6-phosphofructo-1-kinase alpha-subunit, 6-phosphofructo-1-kinase beta-subunit, 6-phosphofructo-1-kinase gamma-subunit, ... 著者 Strater, N, Marek, S, Kuettner, E.B, Kloos, M, Keim, A, Bruser, A, Kirchberger, J, Schoneberg, T. 登録日 2010-09-02 公開日 2010-10-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Molecular architecture and structural basis of allosteric regulation of eukaryotic phosphofructokinases. Faseb J., 25, 2011
6QXJ	Structure of MBP-Mcl-1 in complex with compound 6a 分子名称: (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]amino]propanoic acid, Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, SODIUM ION, ... 著者 Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A. 登録日 2019-03-07 公開日 2019-08-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J.Med.Chem., 62, 2019
1THZ	Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening 分子名称: 2-{(E)-[5-HYDROXY-3-METHYL-1-(2-METHYL-4-SULFOPHENYL)-1H-PYRAZOL-4-YL]DIAZENYL}-4-SULFOBENZOIC ACID, Bifunctional purine biosynthesis protein PURH, POTASSIUM ION 著者 Xu, L, Li, C, Olson, A.J, Wilson, I.A. 登録日 2004-06-01 公開日 2004-09-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J.Biol.Chem., 279, 2004
4QSB	Crystal structure of human carbonic anhydrase isozyme II with 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, Carbonic anhydrase 2, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2014-07-03 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII Plos One, 9, 2014
4QSI	Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-{[(4-tert-butyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide, Carbonic anhydrase 2, ... 著者 Manakova, E, Smirnov, A, Grazulis, S. 登録日 2014-07-04 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII Plos One, 9, 2014
5CN3	X-ray structure of wild-type TTR at 1.30A resolution 分子名称: Transthyretin 著者 Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. 登録日 2015-07-17 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses. Angew.Chem.Int.Ed.Engl., 55, 2016
6B6W	Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase, as-isolated (protein batch 2), oxidized C-cluster 分子名称: CHLORIDE ION, Carbon monoxide dehydrogenase, FE(4)-NI(1)-S(4) CLUSTER, ... 著者 Wittenborn, E.C, Drennan, C.L. 登録日 2017-10-03 公開日 2018-10-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. Elife, 7, 2018
3J8J	Tilted state of actin, T1 分子名称: Actin, alpha skeletal muscle 著者 Galkin, V.E, Orlova, A, Vos, M.R, Schroder, G.F, Egelman, E.H. 登録日 2014-11-07 公開日 2015-01-14 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (12 Å) 主引用文献 Near-atomic resolution for one state of f-actin. Structure, 23, 2015
6H6F	PTC3 holotoxin complex from Photorhabdus luminiscens - Mutant TcC-D651A 分子名称: TcdA1, TcdB2,TccC3,TccC3 著者 Gatsogiannis, C, Merino, F, Roderer, D, Balchin, D, Schubert, E, Kuhlee, A, Hayer-Hartl, M, Raunser, S. 登録日 2018-07-27 公開日 2018-10-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.72 Å) 主引用文献 Tc toxin activation requires unfolding and refolding of a beta-propeller. Nature, 563, 2018
2OPG	The crystal structure of the 10th PDZ domain of MPDZ 分子名称: Multiple PDZ domain protein, SODIUM ION 著者 Gileadi, C, Phillips, C, Elkins, J, Papagrigoriou, E, Ugochukwu, E, Gorrec, F, Savitsky, P, Umeano, C, Berridge, G, Gileadi, O, Salah, E, Edwards, A, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) 登録日 2007-01-29 公開日 2007-02-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The crystal structure of the 10th PDZ domain of MPDZ To be Published

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