PDB: 225399 件ウェブページステータス検索Chemie searchBIRD

---

3RE5	Crystal structure of R4-6 streptavidin 分子名称: GLYCEROL, PENTAETHYLENE GLYCOL, Streptavidin 著者 Malashkevich, V.N, Magalhaes, M, Czecster, C.M, Guan, R, Levy, M, Almo, S.C. 登録日 2011-04-02 公開日 2011-07-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci., 20, 2011
3R2Y	MK2 kinase bound to Compound 1 分子名称: 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE, MALONATE ION, MAP kinase-activated protein kinase 2 著者 Oubrie, A, Leonard, P. 登録日 2011-03-15 公開日 2011-05-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure-based lead identification of ATP-competitive MK2 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
3RJW	Crystal structure of histone lysine methyltransferase g9a with an inhibitor 分子名称: 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Dong, A, Wasney, G.A, Tempel, W, Liu, F, Barsyte, D, Allali-Hassani, A, Chen, X, Chau, I, Hajian, T, Senisterra, G, Chavda, N, Arora, K, Siarheyeva, A, Kireev, D.B, Herold, J.M, Bochkarev, A, Bountra, C, Weigelt, J, Edwards, A.M, Frye, S.V, Arrowsmith, C.H, Brown, P.J, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC) 登録日 2011-04-15 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol., 7, 2011
3R3U	Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - WT/apo 分子名称: CHLORIDE ION, Fluoroacetate dehalogenase, NICKEL (II) ION 著者 Chan, P.W.Y, Yakunin, A.F, Edwards, E.A, Pai, E.F. 登録日 2011-03-16 公開日 2011-05-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Mapping the reaction coordinates of enzymatic defluorination. J.Am.Chem.Soc., 133, 2011
3RPN	Crystal structure of human kappa class glutathione transferase in complex with S-hexylglutathione 分子名称: Glutathione S-transferase kappa 1, S-HEXYLGLUTATHIONE 著者 Wang, B, Peng, Y, Zhang, T, Ding, J. 登録日 2011-04-27 公開日 2011-07-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism. Biochem.J., 439, 2011
3R76	Crystal structure of 2-amino-2-desoxyisochorismate synthase (ADIC) synthase PhzE from Burkholderia lata 383 in complex with benzoate, pyruvate and glutamine 分子名称: Anthranilate/para-aminobenzoate synthases component I, BENZOIC ACID, MAGNESIUM ION, ... 著者 Li, Q.A, Mavrodi, D.V, Thomashow, L.S, Roessle, M, Blankenfeldt, W. 登録日 2011-03-22 公開日 2011-03-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Ligand Binding Induces an Ammonia Channel in 2-Amino-2-desoxyisochorismate (ADIC) Synthase PhzE. J.Biol.Chem., 286, 2011
3RTH	Structure of Bace-1 (Beta-Secretase) in Complex with 6-(2-(3,3-Dimethylbut-1-ynyl)phenyl)quinolin-2-amine 分子名称: 6-[2-(3,3-dimethylbut-1-yn-1-yl)phenyl]quinolin-2-amine, Beta-secretase 1, IODIDE ION 著者 Sickmier, E.A. 登録日 2011-05-03 公開日 2011-08-31 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011
3R41	Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - His280Asn/apo 分子名称: CALCIUM ION, CHLORIDE ION, Fluoroacetate dehalogenase 著者 Chan, P.W.Y, Yakunin, A.F, Edwards, E.A, Pai, E.F. 登録日 2011-03-17 公開日 2011-05-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Mapping the reaction coordinates of enzymatic defluorination. J.Am.Chem.Soc., 133, 2011
3RC4	Molecular mechanisms of viral and host-cell substrate recognition by HCV NS3/4A protease 分子名称: NS3/4A Protease, Product TRIF, SULFATE ION, ... 著者 Romano, K.P, Schiffer, C.A. 登録日 2011-03-30 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease. J.Virol., 85, 2011
3R2O	1.95 A resolution structure of As-Isolated FtnA from Pseudomonas aeruginosa (pH 6.0) 分子名称: Bacterioferritin, SODIUM ION, SULFATE ION 著者 Lovell, S.W, Battaile, K.P, Yao, H, Jepkorir, G, Nama, P.V, Weeratunga, S, Rivera, M. 登録日 2011-03-14 公開日 2011-05-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Two distinct ferritin-like molecules in Pseudomonas aeruginosa: the product of the bfrA gene is a bacterial ferritin (FtnA) and not a bacterioferritin (Bfr). Biochemistry, 50, 2011
3R4B	Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({2-[(1-cyclopentylpiperidin-4-yl)amino]-1,3-benzothiazol-6-yl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-p henylbutan-2-yl}carbamate, HIV-1 protease, PHOSPHATE ION 著者 Schiffer, C.A, Nalam, M.N.L. 登録日 2011-03-17 公開日 2011-09-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors. Antimicrob.Agents Chemother., 55, 2011
3SA3	Crystal structure of wild-type HIV-1 protease in complex with AG23 分子名称: ACETATE ION, N~2~-acetyl-N-[(2S,3R)-4-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-L-isoleucinamide, PHOSPHATE ION, ... 著者 Schiffer, C.A, Nalam, M.N.L. 登録日 2011-06-02 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
3SDI	Structure of yeast 20S open-gate proteasome with Compound 20 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, N~4~-(2,2-dimethylpropyl)-N~1~-{(2S)-1-[(4-methylbenzyl)amino]-1-oxo-4-phenylbutan-2-yl}-N~2~-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-aspartamide, ... 著者 Sintchak, M.D. 登録日 2011-06-09 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome. Bioorg.Med.Chem.Lett., 20, 2010
3SAB	Crystal structure of wild-type HIV-1 protease in complex with AF78 分子名称: 3-hydroxy-N-[(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](3-phenylpropyl)amino}-1-phenylbutan-2-yl]benzamide, PHOSPHATE ION, Protease 著者 Schiffer, C.A, Nalam, M.N.L. 登録日 2011-06-02 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
3SMM	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin J aglycone, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3SIE	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 分子名称: 5-bromo-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, cGMP-specific 3',5'-cyclic phosphodiesterase 著者 Chen, T.T, Chen, T, Xu, Y.C. 登録日 2011-06-17 公開日 2011-08-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem., 54, 2011
3SN4	Crystal structure of putative L-alanine-DL-glutamate epimerase from Burkholderia xenovorans strain LB400 bound to magnesium and alpha-ketoglutarate 分子名称: 2-OXOGLUTARIC ACID, CHLORIDE ION, MAGNESIUM ION, ... 著者 Bonanno, J.B, Patskovsky, Y, Toro, R, Dickey, M, Bain, K.T, Wu, B, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2011-06-28 公開日 2011-07-27 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal structure of putative L-alanine-DL-glutamate epimerase from Burkholderia xenovorans strain LB400 bound to magnesium and alpha-ketoglutarate To be Published
3SAA	Crystal structure of Wild-type HIV-1 protease in complex With AF77 分子名称: N-[(2S,3R)-4-{(cyclohexylmethyl)[(4-methoxyphenyl)sulfonyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-3-hydroxybenzamide, PHOSPHATE ION, Protease 著者 Schiffer, C.A, Nalam, M.N.L. 登録日 2011-06-02 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
3SEO	Crystal structure of VopL C terminal domain 分子名称: CHLORIDE ION, VopL C terminal domain protein 著者 Yu, B, Rosen, M.K, Tomchick, D.R. 登録日 2011-06-10 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.305 Å) 主引用文献 Mechanism of actin filament nucleation by the bacterial effector VopL. Nat.Struct.Mol.Biol., 18, 2011
3SEI	Crystal Structure of Caskin1 Tandem SAMs 分子名称: CHLORIDE ION, Caskin-1, SULFATE ION 著者 Stafford, R.L, Bowie, J.U. 登録日 2011-06-10 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure, 19, 2011
3SKD	Crystal structure of the Thermus thermophilus cas3 HD domain in the presence of Ni2+ 分子名称: NICKEL (II) ION, Putative uncharacterized protein TTHB187 著者 Bailey, S, Mulepati, S. 登録日 2011-06-22 公開日 2011-07-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and Biochemical Analysis of Nuclease Domain of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Protein 3 (Cas3). J.Biol.Chem., 286, 2011
3SMK	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenin A 分子名称: 14-3-3 protein sigma, Cotylenin A, MAGNESIUM ION, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3SMN	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin A-THF 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3SKF	Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with (2S)-2-((3S)-3-(acetylamino)-3-(butan-2-yl)-2-oxopyrrolidin-1-yl)-N-((2S,3R)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2-yl)-4-phenylbutanamide 分子名称: (2S)-2-{(3S)-3-(acetylamino)-3-[(2S)-butan-2-yl]-2-oxopyrrolidin-1-yl}-N-{(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl}-4-phenylbutanamide, Beta-secretase 1, IODIDE ION 著者 Muckelbauer, J.K. 登録日 2011-06-22 公開日 2011-08-31 最終更新日 2011-11-02 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
3T2J	Tetragonal thermolysin in the presence of betaine 分子名称: CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Cahn, J, Hti Lar Seng, N.S, Juers, D. 登録日 2011-07-22 公開日 2011-12-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The use of trimethylamine N-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography. Acta Crystallogr.,Sect.D, 68, 2012

<573574575576577578579580581582583584585586587588>