PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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3OF0	crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain 分子名称: Proto-oncogene tyrosine-protein kinase Src 著者 Boubeva, R, Pernot, L, Perozzo, R, Scapozza, L. 登録日 2010-08-13 公開日 2011-08-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 a single amino-acid dictates the dynamics of the switch between active and inactive C-Src conformation To be Published
3QLG	Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib 分子名称: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Proto-oncogene tyrosine-protein kinase Src 著者 Boubeva, R, Pernot, L, Perozzo, R, Scapozza, L. 登録日 2011-02-02 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A single amino-acid dictates the dynamics of the switch between active and inactive C-src conformation To be Published
3QLF	Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5 分子名称: 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src 著者 Boubeva, R, Pernot, L, Perozzo, R, Scapozza, L. 登録日 2011-02-02 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A single amino-acid dictates the dynamics of the switch between active and inactive C-src conformation To be Published
2W2M	WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR 分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 著者 Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. 登録日 2008-11-03 公開日 2008-11-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
2W2N	WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR 分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 著者 Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. 登録日 2008-11-03 公開日 2008-11-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
2W2O	PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR 分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 著者 Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. 登録日 2008-11-03 公開日 2008-11-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
2W2Q	PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR 分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 著者 Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. 登録日 2008-11-03 公開日 2008-11-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
2W2P	PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR 分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 著者 Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. 登録日 2008-11-03 公開日 2008-11-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
1VJO	Crystal structure of Alanine--glyoxylate aminotransferase (ALR1004) from Nostoc sp. at 1.70 A resolution 分子名称: PYRIDOXAL-5'-PHOSPHATE, alanine--glyoxylate aminotransferase 著者 Joint Center for Structural Genomics (JCSG) 登録日 2004-03-16 公開日 2004-03-23 最終更新日 2023-01-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor Proteins, 58, 2005
1X2A	Crystal Structure of e.coli AspAT complexed with N-phosphopyridoxyl-D-glutamic acid 分子名称: Aspartate aminotransferase, N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-D-GLUTAMIC ACID 著者 Goto, M. 登録日 2005-04-21 公開日 2005-06-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step. Biochemistry, 44, 2005
1X28	Crystal Structure of e.coli AspAT complexed with N-phosphopyridoxyl-L-glutamic acid 分子名称: Aspartate aminotransferase, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid 著者 Goto, M. 登録日 2005-04-21 公開日 2005-06-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step. Biochemistry, 44, 2005
2XYL	CELLULOMONAS FIMI XYLANASE/CELLULASE COMPLEXED WITH 2-DEOXY-2-FLUORO-XYLOBIOSE 分子名称: BETA-1,4-GLYCANASE, beta-D-xylopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-xylopyranose 著者 Monem, V, Birsan, C, Warren, R.A.J, Withers, S.G, Rose, D.R. 登録日 1997-11-20 公開日 1998-03-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Exploring the cellulose/xylan specificity of the beta-1,4-glycanase cex from Cellulomonas fimi through crystallography and mutation. Biochemistry, 37, 1998
2OZR	MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid 分子名称: 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID, ACETOHYDROXAMIC ACID, CALCIUM ION, ... 著者 Johnson, A.R, Pavlovsky, A.G, Ortwine, D.F, Prior, F, Man, C.-F, Bornemeier, D.A, Banotai, C.A, Mueller, W.T, McConnell, P, Yan, C.H, Baragi, V, Lesch, C, Roark, W.H, Lie, J.J, Fasquelle, V, Wilson, M, Robertson, D, Datta, K, Guzman, R, Han, H.-K, Dyer, R.D. 登録日 2007-02-27 公開日 2007-07-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J.Biol.Chem., 282, 2007
2YKV	Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase 分子名称: 1,2-ETHANEDIOL, 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE, BETA-TRANSAMINASE 著者 Wybenga, G.G, Crismaru, C.G, Janssen, D.B, Dijkstra, B.W. 登録日 2011-05-30 公開日 2012-05-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase. J.Biol.Chem., 287, 2012
2YKU	Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase 分子名称: 1,2-ETHANEDIOL, BETA-TRANSAMINASE, GLYCEROL, ... 著者 Wybenga, G.G, Crismaru, C.G, Janssen, D.B, Dijkstra, B.W. 登録日 2011-05-30 公開日 2012-05-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase. J.Biol.Chem., 287, 2012
2YKX	Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase 分子名称: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, BETA-TRANSAMINASE, ... 著者 Wybenga, G.G, Crismaru, C.G, Janssen, D.B, Dijkstra, B.W. 登録日 2011-05-30 公開日 2012-05-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase. J.Biol.Chem., 287, 2012
2YKY	Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase 分子名称: (3S)-3-amino-3-phenylpropanoic acid, 1,2-ETHANEDIOL, BENZENE, ... 著者 Wybenga, G.G, Crismaru, C.G, Janssen, D.B, Dijkstra, B.W. 登録日 2011-05-30 公開日 2012-05-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structural Determinants of the Beta-Selectivity of a Bacterial Aminotransferase. J.Biol.Chem., 287, 2012
1O9R	The X-ray crystal structure of Agrobacterium tumefaciens Dps, a member of the family that protect DNA without binding 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AGROBACTERIUM TUMEFACIENS DPS, ... 著者 Ilari, A, Ceci, P, Chiancone, E. 登録日 2002-12-18 公開日 2003-05-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The Dps Protein of Agrobacterium Tumefaciens Does not Bind to DNA But Protects It Toward Oxidative Cleavage: X-Ray Crystal Structure, Iron Binding, and Hydroxyl-Radical Scavenging Properties J.Biol.Chem., 278, 2003
7E7G	2-aminoethylphosphonate:pyruvate aminotransferase (AEPT) native 分子名称: 2-aminoethylphosphonate--pyruvate transaminase 著者 Jia, H, Zhang, Q, Bartlam, M. 登録日 2021-02-26 公開日 2021-03-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural characterization of a 2-aminoethylphosphonate:pyruvate aminotransferase from Pseudomonas aeruginosa PAO1. Biochem.Biophys.Res.Commun., 552, 2021
1YVX	Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor 分子名称: 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-16 公開日 2005-03-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280, 2005
1BOI	N-TERMINALLY TRUNCATED RHODANESE 分子名称: RHODANESE 著者 Gliubich, F, Berni, R, Cianci, M, Trevino, R.J, Horowitz, P.M, Zanotti, G. 登録日 1998-08-04 公開日 1999-04-27 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 NH2-terminal sequence truncation decreases the stability of bovine rhodanese, minimally perturbs its crystal structure, and enhances interaction with GroEL under native conditions. J.Biol.Chem., 274, 1999
1BOH	SULFUR-SUBSTITUTED RHODANESE (ORTHORHOMBIC FORM) 分子名称: RHODANESE 著者 Gliubich, F, Berni, R, Cianci, M, Trevino, R.J, Horowitz, P.M, Zanotti, G. 登録日 1998-08-04 公開日 1999-04-27 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 NH2-terminal sequence truncation decreases the stability of bovine rhodanese, minimally perturbs its crystal structure, and enhances interaction with GroEL under native conditions. J.Biol.Chem., 274, 1999
1YV2	Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a 分子名称: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-14 公開日 2005-03-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors J.Biol.Chem., 280, 2005
1YVZ	Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor 分子名称: 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-16 公開日 2005-03-22 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280, 2005
1YUY	HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2a 分子名称: RNA-Dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-14 公開日 2005-03-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280, 2005

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