PDB: 1147 件ウェブページステータス検索Chemie searchBIRD

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2QGD	Human transthyretin (TTR) complexed with 2-(3,5-Dibromo-4-hydroxyphenyl)benzoxazole 分子名称: 4-(1,3-BENZOXAZOL-2-YL)-2,6-DIBROMOPHENOL, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2007-06-28 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J.Med.Chem., 51, 2008
2G9K	Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-2',3,3',4',5-Pentachlorobiphenyl 分子名称: 2',3,3',4',5-PENTACHLOROBIPHENYL-4-OL, Transthyretin 著者 Palaninathan, S.K, Smith, C, Safe, S.H, Kelly, J.W, Sacchettini, J.C. 登録日 2006-03-06 公開日 2006-03-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity Chem.Biol., 11, 2004
4MRB	Wild Type Human Transthyretin pH 7.5 分子名称: CALCIUM ION, Transthyretin 著者 Chen, W.J, Wood, S.P. 登録日 2013-09-17 公開日 2014-01-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. Proc.Natl.Acad.Sci.USA, 111, 2014
2QGC	Human transthyretin (TTR) complexed with 2-(3,5-Dimethyl-4-hydroxyphenyl)benzoxazole 分子名称: 4-(1,3-BENZOXAZOL-2-YL)-2,6-DIMETHYLPHENOL, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2007-06-28 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J.Med.Chem., 51, 2008
3GS7	Human transthyretin (TTR) complexed with (E)-3-(2-methoxybenzylideneaminooxy)propanoic acid (inhibitor 13) 分子名称: 3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acid, Transthyretin 著者 Mohamedmohaideen, N.N, Palaninathan, S.K, Orlandini, E, Sacchettini, J.C. 登録日 2009-03-26 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. Plos One, 4, 2009
4MRC	Human Transthyretin Ser52Pro Mutant 分子名称: CALCIUM ION, Transthyretin 著者 Chen, W.J, Wood, S.P. 登録日 2013-09-17 公開日 2014-01-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. Proc.Natl.Acad.Sci.USA, 111, 2014
2GFU	NMR solution structure of the PWWP domain of Mismatch repair protein hMSH6 分子名称: DNA mismatch repair protein MSH6 著者 Laguri, C, Friedrich, N, Axt, M, Gilquin, B, Zinn-Justin, S, Couprie, J. 登録日 2006-03-23 公開日 2007-04-10 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 The PWWP domain of Mismatch Repair protein hMSH6 is involved in double stranded and single stranded DNA binding To be Published
2QGE	Human transthyretin (TTR) complexed with 2-(3,5-Dimethylphenyl)benzoxazole 分子名称: 2-(3,5-DIMETHYLPHENYL)-1,3-BENZOXAZOLE, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2007-06-28 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J.Med.Chem., 51, 2008
2QEL	Crystal structure of the highly amyloidogenic transthyretin mutant TTR G53S/E54D/L55S- heated protein 分子名称: Transthyretin 著者 Karlsson, A, Sauer-Eriksson, A.E. 登録日 2007-06-26 公開日 2007-09-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Heating of proteins as a means of improving crystallization: a successful case study on a highly amyloidogenic triple mutant of human transthyretin Acta Crystallogr.,Sect.F, 63, 2007
3HJ0	Transthyretin in complex with a covalent small molecule kinetic stabilizer 分子名称: 4-fluorophenyl 3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoate, Transthyretin 著者 Connelly, S, Wilson, I.A, Kelly, J.W. 登録日 2009-05-20 公開日 2009-12-22 最終更新日 2014-11-19 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nat.Chem.Biol., 6, 2010
2QGB	Human transthyretin (TTR) in Apo-form 分子名称: Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2007-06-28 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J.Med.Chem., 51, 2008
2H4E	Crystal structure of Cys10 sulfonated transthyretin 分子名称: SULFATE ION, Transthyretin 著者 Gales, L, Damas, A.M. 登録日 2006-05-24 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural basis for the protective role of sulfite against transthyretin amyloid formation. Biochim.Biophys.Acta, 1774, 2007
6FTF	Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.09 A resolution 分子名称: 1,2-ETHANEDIOL, 7-cyano-7-deazainosine, Protein kinase A regulatory subunit, ... 著者 Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. 登録日 2018-02-21 公開日 2019-04-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.09151936 Å) 主引用文献 Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun, 10, 2019
6FXU	Crystal structure of human transthyretin mutant T119M at pH 5.5 分子名称: Transthyretin 著者 Varejao, N, Esperante, S, Ventura, S, Reverter, D. 登録日 2018-03-09 公開日 2019-03-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.359 Å) 主引用文献 Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation. J.Biol.Chem., 297, 2021
6FZL	Crystal structure of human transthyretin double mutant K35T/T119M 分子名称: Transthyretin 著者 Esperante, S, Ventura, S, Reverter, D, Varejao, N. 登録日 2018-03-15 公開日 2019-03-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.446 Å) 主引用文献 Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation. J.Biol.Chem., 297, 2021
6FWD	Crystal structure of human transthyretin double mutant R34G/T119M at pH 5.5 分子名称: Transthyretin 著者 Esperante, S, Ventura, S, Reverter, D, Varejao, N. 登録日 2018-03-06 公開日 2019-03-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.576 Å) 主引用文献 Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation. J.Biol.Chem., 297, 2021
7WL6	Crystal structure of I73L mutated human transthyretin 分子名称: MAGNESIUM ION, Transthyretin 著者 Nakagawa, M, Obita, T, Mizuguchi, M. 登録日 2022-01-12 公開日 2022-11-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.418007 Å) 主引用文献 The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin. Biochem.J., 479, 2022
7W9Q	Crystal structure of V30M-TTR in complex with naringenin derivative-14 分子名称: (2~{R})-2-(3-chloranyl-4-oxidanyl-phenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, CALCIUM ION, Transthyretin 著者 Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. 登録日 2021-12-10 公開日 2022-12-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
7W9R	Crystal structure of V30M-TTR in complex with naringenin derivative-18 分子名称: (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Transthyretin 著者 Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. 登録日 2021-12-10 公開日 2022-12-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
3A4D	Crystal structure of Human Transthyretin (wild-type) 分子名称: GLYCEROL, SULFATE ION, Transthyretin 著者 Miyata, M. 登録日 2009-07-06 公開日 2009-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of the Glutamic Acid 54 Residue in Transthyretin Stability and Thyroxine Binding Biochemistry, 2009
6GR7	Crystal Structure Of Human Transthyretin in complex with 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) 分子名称: 2-[2,4,5-tris(chloranyl)phenoxy]ethanoic acid, Transthyretin 著者 Grundstrom, C, Zhang, J, Olofsson, A, Andersson, P.L, Sauer-Eriksson, A.E. 登録日 2018-06-09 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals. Environ. Sci. Technol., 52, 2018
3A4F	Crystal Structure of Human Transthyretin (E54K) 分子名称: GLYCEROL, SULFATE ION, Transthyretin 著者 Miyata, M, Sato, T, Nakamura, T, Ikemizu, S, Yamagata, Y, Kai, H. 登録日 2009-07-06 公開日 2009-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding Biochemistry, 49, 2010
3A4E	Crystal structure of Human Transthyretin (E54G) 分子名称: GLYCEROL, SULFATE ION, Transthyretin 著者 Miyata, M, Sato, T, Nakamura, T, Ikemizu, S, Yamagata, Y, Kai, H. 登録日 2009-07-06 公開日 2009-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding Biochemistry, 49, 2010
6HTB	Yeast 20S proteasome with human beta2c (S171G) 分子名称: CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... 著者 Huber, E.M, Groll, M. 登録日 2018-10-03 公開日 2019-01-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. J.Med.Chem., 62, 2019
7Y6J	Crystal structure of human transthyretin variant A97S at pH 5.4 分子名称: GLYCEROL, Transthyretin 著者 Wang, Y.S, Huang, C.H, Tzeng, S.R. 登録日 2022-06-20 公開日 2023-05-03 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser. Protein Sci., 32, 2023

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