7DT5
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7DT6
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5L4M
| Crystal Structure of Human Transthyretin in Complex with 3,5,6-Trichloro-2-pyridinyloxyacetic acid (Triclopyr) | 分子名称: | SODIUM ION, Transthyretin, Triclopyr | 著者 | Grundstrom, C, Hall, M, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. | 登録日 | 2016-05-25 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.581 Å) | 主引用文献 | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ. Sci. Technol., 50, 2016
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5H0W
| Crystal structure of H88F mutated human transthyretin | 分子名称: | SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
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4WO0
| Crystal structure of transthyretin in complex with apigenin | 分子名称: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Transthyretin | 著者 | Zanotti, G, Cianci, M, Folli, C, Berni, R. | 登録日 | 2014-10-15 | 公開日 | 2015-08-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.339 Å) | 主引用文献 | Structural evidence for asymmetric ligand binding to transthyretin. Acta Crystallogr.,Sect.D, 71, 2015
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5N7C
| Human TTR altered conformation from soaking in CuCl2. | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, COPPER (II) ION, ... | 著者 | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | 登録日 | 2017-02-20 | 公開日 | 2018-03-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
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5N62
| Human TTR crystals soaked in manganese chloride. | 分子名称: | MANGANESE (II) ION, Transthyretin | 著者 | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | 登録日 | 2017-02-14 | 公開日 | 2018-03-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
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4WNS
| Crystal structure of Transthyretin complexed with pterostilbene | 分子名称: | DIMETHYL SULFOXIDE, Pterostilbene, SULFATE ION, ... | 著者 | Zanotti, G, Cianci, M, Folli, C, Berni, R. | 登録日 | 2014-10-14 | 公開日 | 2015-08-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | Structural evidence for asymmetric ligand binding to transthyretin. Acta Crystallogr.,Sect.D, 71, 2015
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4N85
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4N86
| Crystal structure of human transthyretin complexed with glabridin | 分子名称: | 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, CALCIUM ION, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | 登録日 | 2013-10-17 | 公開日 | 2014-02-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Crystal structures of human transthyretin complexed with glabridin J.Med.Chem., 57, 2014
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7DR6
| PA28alpha-beta in complex with immunoproteasome | 分子名称: | Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... | 著者 | Cong, Y, Xu, C. | 登録日 | 2020-12-26 | 公開日 | 2021-01-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM of mammalian PA28 alpha beta-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28 alpha beta. Nat Commun, 12, 2021
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5H0Y
| Crystal structure of H88Y mutated human transthyretin | 分子名称: | CHLORIDE ION, SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
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5NFE
| Neutron structure of human transthyretin (TTR) T119M mutant at room temperature to 1.85A resolution | 分子名称: | Transthyretin | 著者 | Yee, A.W, Moulin, M, Blakeley, M.P, Ostermann, A, Cooper, J.B, Haertlein, M, Mitchell, E.P, Forsyth, V.T. | 登録日 | 2017-03-14 | 公開日 | 2019-01-02 | 最終更新日 | 2024-05-01 | 実験手法 | NEUTRON DIFFRACTION (1.853 Å), X-RAY DIFFRACTION | 主引用文献 | A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10, 2019
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4WNJ
| Crystal structure of Transthyretin-quercetin complex | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, DIMETHYL SULFOXIDE, Transthyretin | 著者 | Zanotti, G, Cianci, M, Berni, R, Folli, C. | 登録日 | 2014-10-13 | 公開日 | 2015-08-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | 主引用文献 | Structural evidence for asymmetric ligand binding to transthyretin. Acta Crystallogr.,Sect.D, 71, 2015
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5NFW
| Neutron structure of human transthyretin (TTR) S52P mutant at room temperature to 1.8A resolution (quasi-Laue) | 分子名称: | Transthyretin | 著者 | Yee, A.W, Moulin, M, Blakeley, M.P, Cooper, J.B, Haertlein, M, Mitchell, E.P, Forsyth, V.T. | 登録日 | 2017-03-16 | 公開日 | 2019-01-02 | 最終更新日 | 2024-05-01 | 実験手法 | NEUTRON DIFFRACTION (1.8 Å), X-RAY DIFFRACTION | 主引用文献 | A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10, 2019
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7AEP
| Solution structure of U1-A RRM2 (190-282) | 分子名称: | U1 small nuclear ribonucleoprotein A | 著者 | Campagne, S, Allain, F.H. | 登録日 | 2020-09-18 | 公開日 | 2021-02-03 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands. Nucleic Acids Res., 49, 2021
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5LV0
| Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product | 分子名称: | CHLORIDE ION, GLY-VAL-VAL amyloid 35-40 fragment, Neurolysin, ... | 著者 | Masuyer, G, Berntsson, R.P.-A, Teixeira, P.F, Kmiec, B, Glaser, E, Stenmark, P. | 登録日 | 2016-09-12 | 公開日 | 2017-12-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and functional analysis of Neurolysin, a new component of the mitochondrial peptidolytic network To Be Published
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2FMX
| An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+) | 分子名称: | GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Rao, Y, Bian, C, Yuan, C, Li, Y, Huang, M. | 登録日 | 2006-01-10 | 公開日 | 2006-09-05 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+) Biochem.Biophys.Res.Commun., 348, 2006
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3ESP
| Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-3,5-dimethyl-4-hydroxybenzamide | 分子名称: | N-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-3,5-dimethylbenzamide, Transthyretin | 著者 | Connelly, S, Wilson, I.A. | 登録日 | 2008-10-06 | 公開日 | 2009-04-07 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 52, 2009
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2FLM
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5FW7
| Structure of human transthyretin mutant A109V | 分子名称: | TRANSTHYRETIN | 著者 | Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D. | 登録日 | 2016-02-12 | 公開日 | 2017-03-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structure of New Non-Amyloidogenic Mutant of Ttr A108V To be Published
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3DK2
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2G3X
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4Y9E
| Crystal structure of V30M mutated transthyretin in complex with gamma-mangostin | 分子名称: | 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, CHLORIDE ION, Transthyretin | 著者 | Yokoyama, T, Mizuguchi, M. | 登録日 | 2015-02-17 | 公開日 | 2015-09-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5, 2015
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3DID
| Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 soaked | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | 登録日 | 2008-06-20 | 公開日 | 2008-07-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010
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