9BCU
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9BCT
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9BCM
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9BCG
| Myeloid cell leukemia-1 (Mcl-1) complexed with compound | 分子名称: | 7-[(4R,5S,6P)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-4,5-dimethoxy-1-methyl-1H-indole-2-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Zhao, B, Fesik, S.W. | 登録日 | 2024-04-09 | 公開日 | 2024-08-07 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. J.Med.Chem., 67, 2024
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9BCB
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9BC7
| HCN1 M305L holo | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2024-04-08 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
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9BC6
| HCN1 M305L with propofol | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2024-04-07 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
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9BC4
| Transglutaminase 2 - Intermediate State | 分子名称: | CALCIUM ION, GLYCEROL, HB-225 (gluten peptidomimetic TG2 inhibitor), ... | 著者 | Sewa, A.S, Mathews, I.I, Khosla, C. | 登録日 | 2024-04-07 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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9BC3
| Transglutaminase 2 - Alternate state | 分子名称: | CALCIUM ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2 | 著者 | Mathews, I.I, Sewa, A.S, Khosla, C. | 登録日 | 2024-04-07 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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9BC2
| Transglutaminase 2 - Open State | 分子名称: | CHLORIDE ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2, ... | 著者 | Mathews, I.I, Sewa, A, Khosla, C. | 登録日 | 2024-04-07 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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9BBM
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9BBL
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9BBI
| Co-crystal structure of human DDB1 bound to fragment UB028669 | 分子名称: | 3-([1,3]oxazolo[4,5-b]pyridin-2-yl)aniline, DNA damage-binding protein 1, L(+)-TARTARIC ACID, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028669 To be published
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9BBH
| Co-crystal structure of human DDB1 bound to fragment UB028670 | 分子名称: | 1,2-ETHANEDIOL, 4-methoxy-1H-indole, DNA damage-binding protein 1, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028670 To be published
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9BBG
| Co-crystal structure of human DDB1 bound to fragment UB028671 | 分子名称: | 1,2-ETHANEDIOL, 1H-indol-6-amine, DNA damage-binding protein 1, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028671 To be published
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9BBE
| Co-crystal structure of human DDB1 bound to fragment UB028668 | 分子名称: | 5-(4-methoxyphenyl)-3-[(3S)-pyrrolidin-3-yl]-1,2,4-oxadiazole, DNA damage-binding protein 1, L(+)-TARTARIC ACID, ... | 著者 | Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-05 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Co-crystal structure of human DDB1 bound to fragment UB028668 To be published
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9BBB
| Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, cobicistat | 著者 | Sevrioukova, I.F. | 登録日 | 2024-04-05 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Interaction of CYP3A4 with the inhibitor cobicistat: Structural and mechanistic insights and comparison with ritonavir to be published
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9BB7
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9BB6
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9BB5
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9BB4
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9BB3
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9BB2
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9BB1
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9BAZ
| CryoEM structure of DIM2-HP1 complex | 分子名称: | DNA (cytosine-5-)-methyltransferase, Heterochromatin protein one, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Song, J, Shao, Z. | 登録日 | 2024-04-05 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | CryoEM structure of DIM2-HP1 complex To Be Published
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