PDB: 1147 件ウェブページステータス検索Chemie searchBIRD

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3FC8	Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe 分子名称: METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATE, transthyretin 著者 Gales, L, Damas, A.M. 登録日 2008-11-21 公開日 2009-02-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. Plos One, 4, 2009
5FO2	Structure of human transthyretin mutant A108I 分子名称: TRANSTHYRETIN 著者 Varejao, N, Santanna, R, Saraiva, M.J, Gallego, P, Ventura, S, Reverter, D. 登録日 2015-11-17 公開日 2016-11-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.449 Å) 主引用文献 Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation. Sci Rep, 7, 2017
4Y9C	Crystal structure of V30M mutated transthyretin with bromide in complex with alpha-mangostin 分子名称: 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, BROMIDE ION, Transthyretin 著者 Yokoyama, T, Mizuguchi, M. 登録日 2015-02-17 公開日 2015-09-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5, 2015
4Y9G	Crystal structure of V30M mutated transthyretin in complex with 3-isomangostin 分子名称: 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, Transthyretin 著者 Yokoyama, T, Mizuguchi, M. 登録日 2015-02-17 公開日 2015-09-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5, 2015
5K1J	Human TTR altered by a rhenium tris-carbonyl Pyta-C8 derivative 分子名称: 1,2-ETHANEDIOL, ACETATE ION, DIMETHYL SULFOXIDE, ... 著者 Stura, E.A, Ciccone, L, Shepard, W. 登録日 2016-05-18 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Human TTR conformation altered by rhenium tris-carbonyl derivatives. J.Struct.Biol., 195, 2016
2NBO	Solution structure of the F87M/L110M variant of transthyretin in the monomeric state 分子名称: Transthyretin 著者 Kim, J, Oroz, J, Zweckstetter, M. 登録日 2016-03-09 公開日 2017-02-22 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nat. Struct. Mol. Biol., 24, 2017
3DO4	Crystal structure of transthyretin variant T60A at acidic pH 分子名称: ACETATE ION, Transthyretin 著者 Cendron, L, Zanotti, G, Folli, C, Berni, R. 登録日 2008-07-03 公開日 2009-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Amyloidogenic potential of transthyretin variants: Insights from structural and computational analyses To be Published
5FW8	Structure of human transthyretin mutant E89K 分子名称: TRANSTHYRETIN 著者 Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D. 登録日 2016-02-12 公開日 2016-12-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of New Non-Amyloidogenic Mutant of Ttr A108V To be Published
4YDM	High resolution crystal structure of human transthyretin bound to ligand and conjugates of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate 分子名称: 2,6-dichloro-4-[5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol, Transthyretin 著者 Connelly, S, Bradbury, N.C. 登録日 2015-02-22 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. J.Am.Chem.Soc., 137, 2015
3DJR	CRYSTAL STRUCTURE OF TRANSTHYRETIN VARIANT L58H at neutral pH 分子名称: Transthyretin 著者 Cendron, L, Zanotti, G, Folli, C, Berni, R. 登録日 2008-06-24 公開日 2009-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses. J.Biol.Chem., 284, 2009
3DJT	Crystal structure of transthyretin variant V30M at acidic pH 分子名称: Transthyretin 著者 Cendron, L, Zanotti, G, Folli, C, Berni, R. 登録日 2008-06-24 公開日 2009-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses. J.Biol.Chem., 284, 2009
3DK0	Crystal structure of transthyretin variant L55P at acidic pH 分子名称: Transthyretin 著者 Cendron, L, Zanotti, G, Folli, C, Berni, R. 登録日 2008-06-24 公開日 2009-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses. J.Biol.Chem., 284, 2009
5N5Q	Human TTR altered conformation from soaking in iron chloride. 分子名称: ACETATE ION, FE (III) ION, Transthyretin, ... 著者 Ciccone, L, Savko, M, Shepard, W, Stura, E.A. 登録日 2017-02-14 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
4YDN	High resolution crystal structure of human transthyretin bound to ligand and conjugates of 4-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate 分子名称: 2,6-dichloro-4-[5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol, 4-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl sulfurofluoridate, Transthyretin 著者 Connelly, S, Bradbury, N.C. 登録日 2015-02-22 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. J.Am.Chem.Soc., 137, 2015
5JIQ	Crystal Structure of Human Transthyretin in Complex with 2,2',4,4'-tetrahydroxybenzophenone (BP2) 分子名称: GLYCEROL, SODIUM ION, Transthyretin, ... 著者 Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. 登録日 2016-04-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ. Sci. Technol., 50, 2016
4L1S	Covalent modification of transthyretin K15 by yielding the fluorescent conjugate (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzamide 分子名称: S-(4-fluorophenyl) 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzenecarbothioate, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2013-06-03 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn. Biopolymers, 101, 2014
5JID	Crystal Structure of Human Transthyretin in Complex with Perfluorooctanoic acid (PFOA) 分子名称: SODIUM ION, Transthyretin, pentadecafluorooctanoic acid 著者 Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. 登録日 2016-04-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ. Sci. Technol., 50, 2016
5EN3	Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution 分子名称: 2-[3,4-bis(oxidanyl)phenyl]-7-chloranyl-5-oxidanyl-chromen-4-one, GLYCEROL, SODIUM ION, ... 著者 Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E. 登録日 2015-11-09 公開日 2016-04-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. Plos One, 11, 2016
3KGU	Wild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.5 分子名称: GENISTEIN, Transthyretin 著者 Trivella, D.B, Polikarpov, I. 登録日 2009-10-29 公開日 2010-03-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J.Struct.Biol., 170, 2010
7DR7	bovine 20S immunoproteasome 分子名称: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... 著者 Xu, C, Cong, Y. 登録日 2020-12-26 公開日 2021-01-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM of mammalian PA28 alpha beta-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28 alpha beta. Nat Commun, 12, 2021
7DRW	Bovine 20S immunoproteasome in complex with two human PA28alpha-beta activators 分子名称: Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... 著者 Cong, Y, Xu, C. 登録日 2020-12-29 公開日 2021-01-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM of mammalian PA28 alpha beta-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28 alpha beta. Nat Commun, 12, 2021
3KGT	V30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.5 分子名称: GENISTEIN, Transthyretin 著者 Trivella, D.B, Polikarpov, I. 登録日 2009-10-29 公開日 2010-03-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J.Struct.Biol., 170, 2010
3KGS	V30M mutant human transthyretin (TTR) (apoV30M) pH 7.5 分子名称: Transthyretin 著者 Trivella, D.B, Polikarpov, I. 登録日 2009-10-29 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J.Struct.Biol., 170, 2010
7DT8	Crystal structure of V30M mutated transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid 分子名称: 4-chloranyl-9-oxidanylidene-xanthene-2-carboxylic acid, CALCIUM ION, Transthyretin 著者 Kitakami, R, Yokoyama, T, Mizuguchi, M. 登録日 2021-01-04 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem., 44, 2021
7DT3	Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 分子名称: 4-chloranyl-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid, CALCIUM ION, Transthyretin 著者 Kitakami, R, Yokoyama, T, Mizuguchi, M. 登録日 2021-01-04 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.198 Å) 主引用文献 Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem., 44, 2021

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