5LLV
| Crystal structure of DACM F87M/L110M Transthyretin mutant | 分子名称: | ACETATE ION, CHLORIDE ION, Transthyretin | 著者 | Sala, B.M, Ghadami, S.A, Bemporad, F, Chiti, F, Ricagno, S. | 登録日 | 2016-07-28 | 公開日 | 2017-06-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | FRET studies of various conformational states adopted by transthyretin. Cell. Mol. Life Sci., 74, 2017
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3IMR
| Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol | 分子名称: | 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol, Transthyretin | 著者 | Connelly, S, Wilson, I.A. | 登録日 | 2009-08-11 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
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5IZC
| Trypanosoma brucei PTR1 in complex with inhibitor F032 | 分子名称: | ACETATE ION, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Pozzi, C, Landi, G, Di Pisa, F, Mangani, S. | 登録日 | 2016-03-25 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
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3IMW
| Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dimethoxystyryl)aniline | 分子名称: | 2,6-dibromo-4-[(E)-2-(2,6-dimethoxyphenyl)ethenyl]aniline, Transthyretin | 著者 | Connelly, S, Wilson, I.A. | 登録日 | 2009-08-11 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
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3IPB
| Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (11 carbon linker). | 分子名称: | 2,2'-{undecane-1,11-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid, Transthyretin | 著者 | Kolstoe, S.E, Wood, S.P, Pepys, M.B. | 登録日 | 2009-08-17 | 公開日 | 2010-11-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc.Natl.Acad.Sci.USA, 107, 2010
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3ESO
| Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,5-dichlorobenzamide | 分子名称: | 2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamide, Transthyretin | 著者 | Connelly, S, Wilson, I.A. | 登録日 | 2008-10-06 | 公開日 | 2009-04-07 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 52, 2009
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5EZP
| Human transthyretin (TTR) complexed with 4-hydroxy-chalcone | 分子名称: | 1,2-ETHANEDIOL, 4-hydroxy-chalcone, Transthyretin | 著者 | Polsinelli, I, Nencetti, S, Shepard, W.E, Orlandini, E, Stura, E.A. | 登録日 | 2015-11-26 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A new crystal form of human transthyretin obtained with a curcumin derived ligand. J.Struct.Biol., 194, 2016
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3IMS
| Transthyretin in complex with 2,6-dibromo-4-(2,6-dichlorophenethyl)phenol | 分子名称: | 2,6-dibromo-4-[2-(2,6-dichlorophenyl)ethyl]phenol, Transthyretin | 著者 | Connelly, S, Wilson, I.A. | 登録日 | 2009-08-11 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
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5LUZ
| Structure of Human Neurolysin (E475Q) in complex with neurotensin peptide products | 分子名称: | CHLORIDE ION, GLYCEROL, Neurolysin, ... | 著者 | Masuyer, G, Berntsson, R.P.-A, Teixeira, P.F, Kmiec, B, Glaser, E, Stenmark, P. | 登録日 | 2016-09-12 | 公開日 | 2017-12-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin. J. Mol. Biol., 430, 2018
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3ESN
| Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide | 分子名称: | N-(3,5-dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide, Transthyretin | 著者 | Connelly, S, Wilson, I.A. | 登録日 | 2008-10-06 | 公開日 | 2009-04-07 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 52, 2009
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3IPE
| Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker). | 分子名称: | 2,2'-{heptane-1,7-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid, Transthyretin | 著者 | Kolstoe, S.E, Wood, S.P, Pepys, M.B. | 登録日 | 2009-08-17 | 公開日 | 2010-11-17 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc.Natl.Acad.Sci.USA, 107, 2010
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5JIM
| Crystal Structure of Human Transthyretin in Complex with Perfluoroktansulfonsyra (PFOS) | 分子名称: | SODIUM ION, Transthyretin, heptadecafluoro-1-octanesulfonic acid | 著者 | Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. | 登録日 | 2016-04-22 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ. Sci. Technol., 50, 2016
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3IMT
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3I9I
| Crystal structure of human transthyretin variant A25T - #2 | 分子名称: | TRIETHYLENE GLYCOL, Transthyretin | 著者 | Palmieri, L.C, Freire, J.B.B, Palhano, F.L, Azevedo, E.P.C, Foguel, D, Lima, L.M.T.R. | 登録日 | 2009-07-11 | 公開日 | 2011-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of human transthyretin variant A25T - #2 To be Published
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3I9P
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5K1N
| Human TTR altered by a rhenium tris-carbonyl Pyta-C12 derivative | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Stura, E.A, Ciccone, L, Shepard, W. | 登録日 | 2016-05-18 | 公開日 | 2016-07-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Human TTR conformation altered by rhenium tris-carbonyl derivatives. J.Struct.Biol., 195, 2016
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2NOY
| Crystal structure of transthyretin mutant I84S at PH 7.5 | 分子名称: | Transthyretin | 著者 | Pasquato, N, Berni, R, Folli, C, Alfieri, B, Cendron, L, Zanotti, G. | 登録日 | 2006-10-26 | 公開日 | 2007-01-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Acidic pH-induced conformational changes in amyloidogenic mutant transthyretin J.Mol.Biol., 366, 2007
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3IMU
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3FCB
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3IX1
| Periplasmic N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine binding protein from Bacillus halodurans | 分子名称: | N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide, N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine binding protein | 著者 | Bale, S, Rajashankar, K.R, Perry, K, Begley, T.P, Ealick, S.E. | 登録日 | 2009-09-03 | 公開日 | 2010-10-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | HMP Binding Protein ThiY and HMP-P Synthase THI5 Are Structural Homologues. Biochemistry, 49, 2010
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3I9A
| Crystal structure of human transthyretin variant A25T - #1 | 分子名称: | TRIETHYLENE GLYCOL, Transthyretin | 著者 | Palmieri, L.C, Freire, J.B.B, Palhano, F.L, Azevedo, E.P.C, Foguel, D, Lima, L.M.T.R. | 登録日 | 2009-07-10 | 公開日 | 2010-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of human transthyretin variant A25T - #1 To be Published
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4L1T
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4Y9B
| Crystal structure of V30M mutated transthyretin in complex with alpha-mangostin | 分子名称: | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, CALCIUM ION, CHLORIDE ION, ... | 著者 | Yokoyama, T, Mizuguchi, M. | 登録日 | 2015-02-17 | 公開日 | 2015-09-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5, 2015
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4Y9F
| Crystal structure of V30M mutated transthyretin with bromide in complex with gamma-mangostin | 分子名称: | 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, BROMIDE ION, Transthyretin | 著者 | Yokoyama, T, Mizuguchi, M. | 登録日 | 2015-02-17 | 公開日 | 2015-09-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5, 2015
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2NBP
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