PDB: 1147 件ウェブページステータス検索Chemie searchBIRD

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5AN3	Structure of an Sgt1-Skp1 Complex 分子名称: SGT1, SUPPRESSOR OF KINETOCHORE PROTEIN 1 著者 Willhoft, O, Vaughan, C.K. 登録日 2015-09-03 公開日 2017-02-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores. Sci Rep, 7, 2017
1ICT	MONOCLINIC FORM OF HUMAN TRANSTHYRETIN COMPLEXED WITH THYROXINE (T4) 分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN 著者 Wojtczak, A, Neumann, P, Cody, V. 登録日 2001-04-02 公開日 2002-04-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of a new polymorphic monoclinic form of human transthyretin at 3 A resolution reveals a mixed complex between unliganded and T4-bound tetramers of TTR. Acta Crystallogr.,Sect.D, 57, 2001
5BYM	Crystal structure of the RNA-binding domain of yeast Puf5p bound to SMX2 RNA 分子名称: RNA (5'-R(*UP*GP*UP*AP*CP*UP*AP*UP*A)-3'), Suppressor protein MPT5 著者 Qiu, C, Hall, T.M.T. 登録日 2015-06-10 公開日 2015-09-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.708 Å) 主引用文献 RNA regulatory networks diversified through curvature of the PUF protein scaffold. Nat Commun, 6, 2015
5AYT	Crystal structure of transthyretin in complex with L6 分子名称: 2-oxidanyl-6-(phenylcarbonyl)benzo[de]isoquinoline-1,3-dione, Transthyretin 著者 Yokoyama, T, Mizuguchi, M, Kai, H. 登録日 2015-09-03 公開日 2016-01-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione J. Pharmacol. Sci., 129, 2015
1RVS	STRUCTURE OF TRANSTHYRETIN IN AMYLOID FIBRILS DETERMINED BY SOLID-STATE MAGIC ANGLE SPINNING NMR 分子名称: Transthyretin 著者 Jaroniec, C.P, Macphee, C.E, Bajaj, V.S, Mcmahon, M.T, Dobson, C.M, Griffin, R.G. 登録日 2003-12-14 公開日 2004-01-20 最終更新日 2024-05-01 実験手法 SOLID-STATE NMR 主引用文献 High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy Proc.Natl.Acad.Sci.USA, 101, 2004
3ZPK	Atomic-resolution structure of a quadruplet cross-beta amyloid fibril. 分子名称: TRANSTHYRETIN 著者 Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S.A, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M. 登録日 2013-02-28 公開日 2013-12-04 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY, SOLID-STATE NMR 主引用文献 Atomic Structure and Hierarchical Assembly of a Cross-Beta Amyloid Fibril. Proc.Natl.Acad.Sci.USA, 110, 2013
1TTC	THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION 分子名称: Transthyretin 著者 Hamilton, J.A, Steinrauf, L.K, Braden, B.C. 登録日 1992-11-02 公開日 1993-10-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. J.Biol.Chem., 268, 1993
1IJN	Crystal structure of the transthyretin mutant TTR C10A/Y114C 分子名称: BETA-MERCAPTOETHANOL, TRANSTHYRETIN 著者 Eneqvist, T, Karlsson, A, Olofsson, A, Sauer-Eriksson, A.E. 登録日 2001-04-27 公開日 2003-06-03 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Cys114-linked dimers of transthyretin are compatible with amyloid formation Biochemistry, 44, 2005
1III	CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT ROOM TEMPERATURE 分子名称: BETA-MERCAPTOETHANOL, TRANSTHYRETIN 著者 Eneqvist, T, Olofsson, A, Ando, Y, Lundgren, E, Sauer-Eriksson, A.E. 登録日 2001-04-23 公開日 2002-11-15 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Disulfide-Bond Formation in the Transthyretin Mutant Y114C Prevents Amyloid Fibril Formation in Vivo and in Vitro Biochemistry, 41, 2002
2M5N	Atomic-resolution structure of a cross-beta protofilament 分子名称: Transthyretin 著者 Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M. 登録日 2013-02-27 公開日 2013-07-17 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 Atomic structure and hierarchical assembly of a cross-{beta} amyloid fibril. Proc.Natl.Acad.Sci.USA, 110, 2013
4HIQ	The Structure of V122I Mutant Transthyretin in Complex with AG10 分子名称: 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid, Transthyretin 著者 Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. 登録日 2012-10-11 公開日 2013-06-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
4HJS	Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide 分子名称: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2012-10-14 公開日 2013-12-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
4HIS	The Structure of V122I Mutant Transthyretin in Complex with Tafamidis 分子名称: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin 著者 Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. 登録日 2012-10-11 公開日 2013-06-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
4HJU	Transthyretin in complex with (E)-N-(3-(4-hydroxy-3,5-dimethylstyryl)phenyl)acrylamide 分子名称: N-{3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}prop-2-enamide, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2012-10-14 公開日 2013-12-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
4HJT	Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide 分子名称: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2012-10-14 公開日 2013-12-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
4I89	Crystal structure of transthyretin in complex with diflunisal at acidic pH 分子名称: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin 著者 Zanotti, G, Cendron, L, Folli, C, Florio, P, Imbimbo, B.P, Berni, R. 登録日 2012-12-03 公開日 2013-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors. Febs Lett., 587, 2013
6TXW	V30G Transthyretin structure in complex with Tolcalpone 分子名称: Tolcapone, Transthyretin 著者 Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. 登録日 2020-01-14 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.153 Å) 主引用文献 Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
6TXV	A25T Transthyretin structure in complex with Tolcalpone 分子名称: Tolcapone, Transthyretin 著者 Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. 登録日 2020-01-14 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
4DES	Crystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR) 分子名称: Transthyretin, chrysin 著者 Trivella, D.B.B, Polikarpov, I. 登録日 2012-01-21 公開日 2012-11-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
4DER	Crystal Structure of the Wild Type TTR Binding Apigenin (TTRwt:API) 分子名称: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, GLYCEROL, Transthyretin 著者 Trivella, D.B.B, Polikarpov, I. 登録日 2012-01-21 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
4IKK	Crystal structure of wild-type human transthyretin in complex with sulindac 分子名称: Transthyretin, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid 著者 Lima, L.M.T.R. 登録日 2012-12-26 公開日 2013-01-30 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of wild-type human transthyretin in complex with sulindac To be Published
6U0Q	Transthyretin in complex with (E)-5,5'-(ethene-1,2-diyl)bis(1,1-dihydroxy-3-oxo-1,3-dihydrobenzo[c][1,2]oxaborol-1-uide) 分子名称: 3-[(~{E})-2-[7,7-bis(oxidanyl)-9-oxidanylidene-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-3-yl]ethenyl]-7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-9-one, Transthyretin 著者 Windsor, I.W, Graham, B.J, Raines, R.T. 登録日 2019-08-14 公開日 2021-01-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Boronic acid with high oxidative stability and utility in biological contexts. Proc.Natl.Acad.Sci.USA, 118, 2021
4IKL	Crystal structure of wild-type human transthyretin in complex with sulindac 分子名称: Transthyretin, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid 著者 Lima, L.M.T.R, Polikarpov, I. 登録日 2012-12-26 公開日 2013-01-30 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of wild-type human transthyretin in complex with sulindac To be Published
4DET	Crystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE) 分子名称: 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, Transthyretin 著者 Trivella, D.B.B, Polikarpov, I. 登録日 2012-01-22 公開日 2012-11-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
6SUG	Crystal structure of transthyretin in complex with 3-deoxytolcapone, a tolcapone analogue 分子名称: 3-deoxytolcapone, Transthyretin 著者 Loconte, V, Cianci, M, Menozzi, I, Sbravati, D, Sansone, F, Casnati, A, Berni, R. 登録日 2019-09-14 公開日 2020-08-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin. Bioorg.Chem., 103, 2020

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