PDB: 1147 件ウェブページステータス検索Chemie searchBIRD

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4ABW	Crystal Structure of Transthyretin in Complex With Ligand C-6 分子名称: TRANSTHYRETIN, {4-[4-(hydroxymethyl)-2-methoxyphenoxy]benzene-1,3-diyl}bis[hydroxy(oxo)ammonium] 著者 Tomar, D, Khan, T, Singh, R.R, Mishra, S, Gupta, S, Surolia, A, Salunke, D.M. 登録日 2011-12-11 公開日 2012-09-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystallographic Study of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity between Two Thyroxine Binding Sites. Plos One, 7, 2012
1FHN	TRANSTHYRETIN STABILITY AS A KEY FACTOR IN AMYLOIDOGENESIS 分子名称: Transthyretin 著者 Sebastiao, M.P. 登録日 2000-08-02 公開日 2001-07-25 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution. J.Mol.Biol., 306, 2001
6R68	Crystal structure of transthyretin in complex with CHF4795, a flurbiprofen analogue 分子名称: (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]propanoic acid, Transthyretin 著者 Loconte, V, Menozzi, I, Ferrari, A, Berni, R, Zanotti, G. 登録日 2019-03-26 公開日 2019-09-11 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208, 2019
6R6I	Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue 分子名称: 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, PHOSPHATE ION, Transthyretin 著者 Loconte, V, Menozzi, I, Ferrari, A, Berni, R, Zanotti, G. 登録日 2019-03-27 公開日 2019-09-11 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.467 Å) 主引用文献 Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208, 2019
1FT4	PHOTOCHEMICALLY-ENHANCED BINDING OF SMALL MOLECULES TO THE TUMOR NECROSIS FACTOR RECEPTOR-1 分子名称: 5-(3-MORPHOLIN-4-YL-PROPYL)-2-(3-NITRO-PHENYL)-4-THIOXO-4,5-DIHYDRO-1-THIA-3B,5-DIAZA-CYCLOPENTA[A]PENTALEN-6-ONE, SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1 著者 Muckelbauer, J.K, Chang, C.-H. 登録日 2000-09-11 公開日 2001-10-12 最終更新日 2017-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha. Proc.Natl.Acad.Sci.USA, 98, 2001
8II1	Crystal structure of V30M-TTR in complex with BID 分子名称: Benziodarone, Transthyretin 著者 Yokoyama, T. 登録日 2023-02-24 公開日 2023-06-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.907 Å) 主引用文献 Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
8II3	Crystal structure of V30M-TTR in complex with 6-hydroxy BID 分子名称: Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone 著者 Yokoyama, T. 登録日 2023-02-24 公開日 2023-06-28 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.399 Å) 主引用文献 Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
8II4	Crystal structure of V30M-TTR in complex with 6-hydroxy BBM 分子名称: Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone 著者 Yokoyama, T. 登録日 2023-02-24 公開日 2023-06-28 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.499 Å) 主引用文献 Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
8II2	Crystal structure of V30M-TTR in complex with BBM 分子名称: CALCIUM ION, Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone 著者 Yokoyama, T. 登録日 2023-02-24 公開日 2023-06-28 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.798 Å) 主引用文献 Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
5E4A	Human transthyretin (TTR) complexed with (2,7-Dichloro-fluoren-9-ylideneaminooxy)-acetic acid. 分子名称: Transthyretin, {[(2,7-dichloro-9H-fluoren-9-ylidene)amino]oxy}acetic acid 著者 Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E, Stura, E.A. 登録日 2015-10-05 公開日 2016-03-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR). J Enzyme Inhib Med Chem, 31, 2016
1KGI	Rat transthyretin (also called prealbumin) complex with 3,3',5,5'-tetraiodothyroacetic acid (t4ac) 分子名称: 3,3',5,5'-TETRAIODOTHYROACETIC ACID, TRANSTHYRETIN 著者 Wojtczak, A, Neumann, P, Muziol, T, Cody, V, Luft, J.R, Pangborn, W. 登録日 2001-11-27 公開日 2002-11-27 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution. Acta Biochim.Pol., 48, 2001
8HYG	Crystal structure of protease-associated domain of Arabidopsis vacuolar sorting receptor 1 at pH 4.6 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, CHLORIDE ION, ... 著者 Tsao, H.E, Lui, S.N, Wong, K.B. 登録日 2023-01-06 公開日 2023-01-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of protease-associated domain of Arabidopsis vacuolar sorting receptor 1 at pH 4.6 To Be Published
1FH2	TRANSTHYRETIN STABILITY AS A KEY FACTOR IN AMYLOIDOGENESIS 分子名称: TRANSTHYRETIN 著者 Sebastiao, M.P. 登録日 2000-07-31 公開日 2001-07-25 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution. J.Mol.Biol., 306, 2001
8HY4	Crystal structure of human transthyretin variant A97S at pH 7.6 分子名称: Transthyretin 著者 Wang, Y.S, Huang, C.H, Tzeng, S.R. 登録日 2023-01-05 公開日 2023-05-03 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser. Protein Sci., 32, 2023
1SOK	Crystal structure of the transthyretin mutant A108Y/L110E solved in space group p21212 分子名称: Transthyretin 著者 Hornberg, A, Olofsson, A, Eneqvist, T, Lundgren, E, Sauer-Eriksson, A.E. 登録日 2004-03-15 公開日 2004-07-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The beta-strand D of transthyretin trapped in two discrete conformations Biochim.Biophys.Acta, 1700, 2004
5DWP	Crystal Structure of human transthyretin (TTR) processed with the CrystalDirect automated mounting and cryo-cooling technology 分子名称: Transthyretin 著者 Zander, U, Cornaciu, I, Forsyth, T, Yee, A, Marquez, J.A. 登録日 2015-09-22 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Automated harvesting and processing of protein crystals through laser photoablation. Acta Crystallogr D Struct Biol, 72, 2016
8PMA	Crystal structure of human V30M transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) 分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin 著者 Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. 登録日 2023-06-28 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
8PMO	Crystal structure of human V122I transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) 分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin 著者 Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. 登録日 2023-06-29 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
8PM8	V30M Transthyretin structure in complex with Tolcalpone 分子名称: Tolcapone, Transthyretin 著者 Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. 登録日 2023-06-28 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
8PM9	Crystal structure of human wild type transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) 分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin 著者 Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. 登録日 2023-06-28 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
3OZK	Crystal structure of human transthyretin variant A25T in complex with thyroxine (T4) 分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, Transthyretin 著者 Lima, L.M.T.R, Palmieri, L.C, Foguel, D, Palhano, F.L. 登録日 2010-09-25 公開日 2011-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of human transthyretin variant A25T in complex with thyroxine (T4) To be Published
3P3S	Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one 分子名称: (5Z)-2-amino-5-(3,5-dibromo-4-hydroxybenzylidene)-1-methyl-1,5-dihydro-4H-imidazol-4-one, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2010-10-05 公開日 2011-08-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011
8TDO	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, variant-type morphology 分子名称: Transthyretin 著者 Nguyen, B.A, Singh, V, Saelices, L. 登録日 2023-07-04 公開日 2023-12-13 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
8TDN	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, wild-type morphology 分子名称: Transthyretin 著者 Nguyen, B.A, Singh, V, Saelices, L. 登録日 2023-07-04 公開日 2023-12-13 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
3P3U	Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole 分子名称: 4-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2010-10-05 公開日 2011-08-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011

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