PDB: 66724 件ウェブページステータス検索Chemie searchBIRD

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6SLW	Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 著者 Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. 登録日 2019-08-20 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6UE3	Crystal structure of HCV NS3/4A D168A protease in complex with PC (JZ01-15) 分子名称: 1,2-ETHANEDIOL, GLYCEROL, NS3 protease, ... 著者 Zephyr, J, Schiffer, C.A. 登録日 2019-09-20 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors. Mbio, 11, 2020
6UDB	Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions 分子名称: DI(HYDROXYETHYL)ETHER, Streptavidin 著者 Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. 登録日 2019-09-19 公開日 2020-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
5YFV	Crystal structure of ribose-1,5-bisphosphate isomerase mutant C135S from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate and AMP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,5-di-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
6TRJ	LEDGF/p75 IBD dimer 分子名称: PC4 and SFRS1-interacting protein 著者 Kugler, M, Brynda, J. 登録日 2019-12-19 公開日 2020-09-09 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Fine-tuning of the LEDGF/p75 interaction network by dimerization Structure
5YFW	Crystal structure of ribose-1,5-bisphosphate isomerase mutant D204N from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate and AMP 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,5-di-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
5YGA	Crystal structure of ribose-1,5-bisphosphate isomerase mutant D204N from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate, AMP and GMP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,5-di-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
5YG6	Crystal structure of ribose-1,5-bisphosphate isomerase mutant C135S from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate and GMP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,5-di-O-phosphono-alpha-D-ribofuranose, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
6SGV	Crystal structure of AcAChBP in complex with hosieine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Hosieine, ... 著者 Hunter, W.N, Dawson, A, Parker, H. 登録日 2019-08-05 公開日 2020-08-26 最終更新日 2022-09-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (-)-hosieine-A Acta Crystallogr.,Sect.F, 2022
5YG7	Crystal structure of ribose-1,5-bisphosphate isomerase mutant D204N from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate and GMP 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,5-di-O-phosphono-alpha-D-ribofuranose, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
5YFS	Crystal structure of ribose-1,5-bisphosphate isomerase mutant C135S from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,5-di-O-phosphono-alpha-D-ribofuranose, CHLORIDE ION, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
6US2	MTH1 in complex with compound 5 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, N-[5-(2,3-dimethylphenyl)-1,2,3,4-tetrahydro-1,6-naphthyridin-7-yl]acetamide 著者 Newby, Z.E.R, Lansdon, E.B. 登録日 2019-10-24 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.80012655 Å) 主引用文献 Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. Acs Med.Chem.Lett., 11, 2020
6UUX	Schistosoma mansoni (Blood Fluke) Sulfotransferase/Hycanthone Complex 分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase, hycanthone 著者 Taylor, A.B. 登録日 2019-11-01 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular basis for hycanthone drug action in schistosome parasites. Mol.Biochem.Parasitol., 236, 2020
6UWK	Engineered variant of I-OnuI meganuclease with improved stability and fully altered specificity targeting human chromosome 11 trans integration site 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ... 著者 Werther, R, Stoddard, B.L. 登録日 2019-11-05 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.533 Å) 主引用文献 Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition. Structure, 28, 2020
6UTM	Native E. coli Glyceraldehyde 3-phosphate dehydrogenase 分子名称: GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase, SN-GLYCEROL-3-PHOSPHATE, ... 著者 Rodriguez-Hernandez, A, Romo-Arevalo, E, Rodriguez-Romero, A. 登録日 2019-10-29 公開日 2019-12-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 A Novel Substrate-Binding Site in the X-Ray Structure of an Oxidized E. coli Glyceraldehyde 3-Phosphate Dehydrogenase Elucidated by Single-Wavelength Anomalous Dispersion Crystals, 9, 2019
6UOE	3-25 Fab germline-reversion variant bound to an HCMV gB-derived peptide 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-25 Fab heavy chain, 3-25 Fab light chain, ... 著者 Wrapp, D, McLellan, J.S. 登録日 2019-10-14 公開日 2020-07-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step. Plos Pathog., 16, 2020
6US4	MTH1 in complex with compound 32 分子名称: 5-(2,3-dichlorophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase 著者 Newby, Z.E.R, Lansdon, E.B. 登録日 2019-10-24 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.95032907 Å) 主引用文献 Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. Acs Med.Chem.Lett., 11, 2020
5OX3	Glycogen Phosphorylase in complex with SzB102v 分子名称: (1S)-1,5-anhydro-1-[3-(4-hydroxyphenyl)-1H-1,2,4-triazol-5-yl]-D-glucitol, Glycogen phosphorylase, muscle form, ... 著者 Kyriakis, E, Stravodimos, G.A, Kantsadi, A.L, Chatzileontiadou, D.S.M, Leonidas, D.D. 登録日 2017-09-05 公開日 2018-02-28 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Probing the beta-pocket of the active site of human liver glycogen phosphorylase with 3-(C-beta-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors. Bioorg. Chem., 77, 2018
5YFX	Crystal structure of ribose-1,5-bisphosphate isomerase mutant D204N from Pyrococcus horikoshii OT3 in complex with ribose-1,5-bisphosphate and AMP 分子名称: 1,5-di-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, Ribose 1,5-bisphosphate isomerase 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
2AD1	Human Sulfotransferase SULT1C2 分子名称: Sulfotransferase 1C2 著者 Dong, A, Dombrovski, L, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2005-07-19 公開日 2005-08-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and chemical profiling of the human cytosolic sulfotransferases. Plos Biol., 5, 2007
5YFJ	Crystal structure of ribose-1,5-bisphosphate isomerase from Pyrococcus horikoshii OT3 in complex with ribulose-1,5-bisphosphate 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-21 公開日 2018-02-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
5D1J	CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH N-[5-[[[5-(1,1-DIMETHYLETHYL)-2-OXAZOLYL] METHYL]THIO]-2-THIAZOLYL]-4-PIPERIDINECARBOXAMIDE (BMS-387032) 分子名称: Cyclin-dependent kinase 2, N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide 著者 Sack, J.S. 登録日 2015-08-04 公開日 2015-08-12 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 N-(Cycloalkylamino)Acyl-2-Aminothiazole Inhibitors Of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl) -2-Oxazolyl]Methyl]Thio]-2-Thiazolyl]-4-Piperidinecarboxamide (Bms-387032), A Highly Efficacious And Selective Antitumor Agent J.Med.Chem., 47, 2004
6T37	Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Glucose-1-phosphate thymidylyltransferase, ... 著者 Alphey, M.S, Xiao, G, Westwood, J.N. 登録日 2019-10-10 公開日 2020-08-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.079 Å) 主引用文献 Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorg.Med.Chem., 50, 2021
5YG5	Crystal structure of ribose-1,5-bisphosphate isomerase from Pyrococcus horikoshii OT3 in complex with ribulose-1,5-bisphosphate and GMP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Gogoi, P, Kanaujia, S.P. 登録日 2017-09-22 公開日 2018-02-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. Sci Rep, 8, 2018
5OX1	Glycogen Phosphorylase in complex with JLH270 分子名称: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-[5-(4-methoxyphenyl)-1~{H}-1,2,4-triazol-3-yl]oxane-3,4,5-triol, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... 著者 Kyriakis, E, Stravodimos, G.A, Kantsadi, A.L, Chatzileontiadou, D.S.M, Leonidas, D.D. 登録日 2017-09-05 公開日 2018-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Probing the beta-pocket of the active site of human liver glycogen phosphorylase with 3-(C-beta-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors. Bioorg. Chem., 77, 2018

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