PDB: 1147 件ウェブページステータス検索Chemie searchBIRD

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7ERJ	Crystal structure of V30M-TTR in complex with dichlorophen 分子名称: 4-chloranyl-2-[(5-chloranyl-2-oxidanyl-phenyl)methyl]phenol, CALCIUM ION, Transthyretin 著者 Yokoyama, T, Kashihara, M, Mizuguchi, M. 登録日 2021-05-06 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.892 Å) 主引用文献 Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J.Med.Chem., 64, 2021
7ERK	Crystal structure of V30M-TTR in complex with dasatinib 分子名称: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Transthyretin 著者 Yokoyama, T, Kashihara, M, Mizuguchi, M. 登録日 2021-05-06 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J.Med.Chem., 64, 2021
7ERI	Crystal structure of V30M-TTR in complex with triclabendazole 分子名称: 6-[2,3-bis(chloranyl)phenoxy]-5-chloranyl-2-methylsulfanyl-1H-benzimidazole, Transthyretin 著者 Yokoyama, T, Kashihara, M, Mizuguchi, M. 登録日 2021-05-06 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.813 Å) 主引用文献 Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J.Med.Chem., 64, 2021
8ADE	Wild type ATTR amyloid fibril from senile systemic amyloidosis 分子名称: Transthyretin 著者 Schmidt, M, Steinebrei, M. 登録日 2022-07-08 公開日 2022-11-23 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.78 Å) 主引用文献 Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis. Nat Commun, 13, 2022
7F2D	Arabidopsis thaliana protease-associated domain of vacuolar-sorting receptor 1 in complex with cruciferin 1 C-terminal pentapeptide RVAAA (pH9) 分子名称: Cruciferin 1 C-terminal peptide, Vacuolar-sorting receptor 1 著者 Lui, S.N, Wong, K.B. 登録日 2021-06-10 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural insights into how vacuolar sorting receptors recognize the sorting determinants of seed storage proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
7F2I	Arabidopsis thaliana protease-associated domain of vacuolar-sorting receptor 1 in complex with cruciferin 1 C-terminal pentapeptide RVAAA (pH6.5) 分子名称: Cruciferin 1 C-terminal peptide, Vacuolar-sorting receptor 1 著者 Lui, S.N, Wong, K.B. 登録日 2021-06-11 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural insights into how vacuolar sorting receptors recognize the sorting determinants of seed storage proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
3NEX	V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24) 分子名称: GLYCEROL, Transthyretin, [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID 著者 Trivella, D.B.B, Polikarpov, I. 登録日 2010-06-09 公開日 2010-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition. J.Struct.Biol., 173, 2011
8AWI	Crystal structure of Human Transthyretin at 1.15 Angstrom resolution 分子名称: SODIUM ION, Transthyretin 著者 Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A. 登録日 2022-08-29 公開日 2023-03-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands. Acs Chem Neurosci, 14, 2023
5BOJ	Crystal Structure of Human Transthyretin in Complex with Gemfibrozil 分子名称: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid, SODIUM ION, Transthyretin 著者 Begum, A, Olofsson, A, Sauer-Eriksson, A.E. 登録日 2015-05-27 公開日 2015-08-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. J.Med.Chem., 58, 2015
8G9R	Cardiac amyloid fibrils extracted from a wild-type ATTR amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Saelices, L. 登録日 2023-02-21 公開日 2024-02-21 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. Commun Biol, 7, 2024
8AWW	Transthyretin conjugated with a tafamidis derivative 分子名称: Transthyretin, ~{N}-(6-azanylhexyl)-2-[3,5-bis(chloranyl)phenyl]-1,3-benzoxazole-6-carboxamide 著者 Cerofolini, L, Vasa, K, Bianconi, E, Salobehaj, M, Cappelli, G, Licciardi, G, Perez-Rafols, A, Padilla Cortes, L.D, Antonacci, S, Rizzo, D, Ravera, E, Calderone, V, Parigi, G, Luchinat, C, Macchiarulo, A, Menichetti, S, Fragai, M. 登録日 2022-08-30 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Combining Solid-State NMR with Structural and Biophysical Techniques to Design Challenging Protein-Drug Conjugates. Angew.Chem.Int.Ed.Engl., 62, 2023
1TT6	The orthorhombic crystal structure of transthyretin in complex with diethylstilbestrol 分子名称: DIETHYLSTILBESTROL, GLYCEROL, SULFATE ION, ... 著者 Morais-de-Sa, E.M, Pereira, P.J.B, Saraiva, M.J, Damas, A.M. 登録日 2004-06-22 公開日 2004-10-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors J.Biol.Chem., 279, 2004
1TZ8	The monoclinic crystal structure of transthyretin in complex with diethylstilbestrol 分子名称: ACETATE ION, CARBONATE ION, DIETHYLSTILBESTROL, ... 著者 Morais-de-Sa, E.M, Pereira, P.J.B, Saraiva, M.J, Damas, A.M. 登録日 2004-07-09 公開日 2004-10-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors J.Biol.Chem., 279, 2004
1U21	transthyretin with tethered inhibitor on one monomer. 分子名称: 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin 著者 Wiseman, R.L, Johnson, S.M, Kelker, M.S, Foss, T, Wilson, I.A, Kelly, J.W. 登録日 2004-07-16 公開日 2005-06-28 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Kinetic stabilization of an oligomeric protein by a single ligand binding event J.Am.Chem.Soc., 127, 2005
3W3B	Crystal structure of wild-type human transthyretin 分子名称: Transthyretin 著者 Lima, L.M.T.R. 登録日 2012-12-19 公開日 2013-01-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of wild-type human transthyretin TO BE PUBLISHED
3P3T	Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole 分子名称: 4-[3-(2-fluorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2010-10-05 公開日 2011-08-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011
5CM1	X-ray structure of perdeuterated TTR mutant - T119M at 1.22A 分子名称: Transthyretin 著者 Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. 登録日 2015-07-16 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 X-ray structure of perdeuterated TTR mutant - T119M at 1.22A To Be Published
3P3R	Transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone 分子名称: (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2010-10-05 公開日 2011-08-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011
1GKO	An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured 分子名称: TRANSTHYRETIN 著者 Jiang, X, Smith, C.S, Petrassi, H.M, Hammarstrom, P, White, J.T, Sacchettini, J.C, Kelly, J.W. 登録日 2001-08-17 公開日 2001-11-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 An Engineered Transthyretin Monomer that is Nonamyloidogenic, Unless It is Partially Denatured Biochemistry, 40, 2001
8GBR	Cardiac amyloid fibrils extracted from a wild-type ATTR amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Saelices, L. 登録日 2023-02-28 公開日 2024-02-28 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. Commun Biol, 7, 2024
5CLX	X-ray structure of perdeuterated TTR mutant - S52P at 1.28A resolution 分子名称: GLYCEROL, Transthyretin 著者 Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. 登録日 2015-07-16 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 X-ray structure of perdeuterated TTR mutant - S52P at 1.28A resolution To Be Published
2ISV	Structure of Giardia fructose-1,6-biphosphate aldolase in complex with phosphoglycolohydroxamate 分子名称: PHOSPHOGLYCOLOHYDROXAMIC ACID, Putative fructose-1,6-bisphosphate aldolase, ZINC ION 著者 Galkin, A, Herzberg, O. 登録日 2006-10-18 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia. J.Biol.Chem., 282, 2007
5CLY	X-ray structure of TTR mutant - S52P at 1.23A resolution 分子名称: GLYCEROL, Transthyretin 著者 Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. 登録日 2015-07-16 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 X-ray structure of TTR mutant - S52P at 1.23A resolution To Be Published
5CLZ	X-ray structure of TTR mutant - T119M at 1.22A resolution 分子名称: Transthyretin 著者 Yee, A.W, Moulin, M, Mossou, E, Cooper, J.B, Haertlein, M, Mitchell, E.P, Forsyth, V.T. 登録日 2015-07-16 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 X-ray structure of TTR mutant - T119M at 1.22A resolution To Be Published
5CN3	X-ray structure of wild-type TTR at 1.30A resolution 分子名称: Transthyretin 著者 Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. 登録日 2015-07-17 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses. Angew.Chem.Int.Ed.Engl., 55, 2016

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