PDB: 1147 件ウェブページステータス検索Chemie searchBIRD

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3DJS	Crystal structure of transthyretin variant L58H at acidic pH 分子名称: Transthyretin 著者 Cendron, L, Zanotti, G, Folli, C, Berni, R. 登録日 2008-06-24 公開日 2009-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses. J.Biol.Chem., 284, 2009
3DJZ	Crystal structure of transthyretin variant L55P at neutral pH 分子名称: Transthyretin 著者 Cendron, L, Zanotti, G, Folli, C, Berni, R. 登録日 2008-06-24 公開日 2009-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses. J.Biol.Chem., 284, 2009
7PXX	The crystal structure of Leishmania major Pteridine Reductase 1 in complex with substrate folic acid 分子名称: DI(HYDROXYETHYL)ETHER, FOLIC ACID, GLYCEROL, ... 著者 Di Pisa, F, Dello Iacono, L, Mangani, S. 登録日 2021-10-08 公開日 2022-04-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP + /NADPH and the substrate folic acid. Acta Crystallogr.,Sect.F, 78, 2022
2WQA	Complex of TTR and RBP4 and Oleic Acid 分子名称: OLEIC ACID, RETINOL-BINDING PROTEIN 4, SULFATE ION, ... 著者 Nanao, M, Mercer, D, Nguyen, L, Buckley, D, Stout, T.J. 登録日 2009-08-14 公開日 2010-09-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal Structure of Rbp4 Bound to Linoleic Acid and Ttr To be Published
8C86	Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2 分子名称: (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin 著者 Poonsiri, T, Benini, S, Loconte, V, Cianci, M. 登録日 2023-01-18 公開日 2024-01-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
8C85	Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1 分子名称: (3,5-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin 著者 Poonsiri, T, Benini, S, Loconte, V, Cianci, M. 登録日 2023-01-18 公開日 2024-01-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
8DW5	Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid 分子名称: 2-[(3,5-dichlorophenyl)amino]benzoic acid, Transthyretin 著者 Truong, J.Q, Holdsworth, B, Holien, J.K. 登録日 2022-07-31 公開日 2022-08-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Structural Analysis of the Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid at 1.5 angstrom Resolution. Molecules, 27, 2022
8E0A	Crystal structure of human Sar1b 分子名称: GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION 著者 Huang, Q. 登録日 2022-08-08 公開日 2022-11-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.797 Å) 主引用文献 The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
8E0D	Crystal structure of human Sar1bE140D 分子名称: GTP-binding protein SAR1b, GUANOSINE-5',3'-TETRAPHOSPHATE 著者 Huang, Q. 登録日 2022-08-08 公開日 2022-11-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.981 Å) 主引用文献 The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
8E0C	Crystal structure of human Sar1bH79G 分子名称: GTP-binding protein SAR1b, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION 著者 Huang, Q. 登録日 2022-08-08 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.993 Å) 主引用文献 The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
8E7H	Cryo-EM structure of cardiac amyloid fibril from a wild-type amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Saelices, L. 登録日 2022-08-23 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cardiac amyloid fibrils extracted from a wild-type ATTR amyloidosis patient To Be Published
8E7E	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Singh, V, Afrin, S, Saelices, L. 登録日 2022-08-23 公開日 2023-08-30 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
8E7J	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Saelices, L. 登録日 2022-08-24 公開日 2023-08-30 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
8E7D	Cryo-EM structure of wild-type transthyretin amyloid from heart tissue 分子名称: Transthyretin 著者 Nguyen, B.A, Saelices, L. 登録日 2022-08-23 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 Cardiac amyloid fibrils extracted from a wild-type ATTR amyloidosis patient To Be Published
7Q3I	Human Transthyretin expressed in Vibrio natriegens 分子名称: Transthyretin 著者 Hild Walett, O, Hammarstrom, P. 登録日 2021-10-27 公開日 2022-11-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Human Transthyretin expressed in Vibrio natriegens To Be Published
6N34	Crystal structure of the BTB domain of Human NS1-BP 分子名称: Influenza virus NS1A-binding protein 著者 Zhang, K, Shang, G, Padavannil, A, Fontoura, B, Chook, Y.M. 登録日 2018-11-14 公開日 2018-12-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6N3H	Crystal structure of Kelch domain of the human NS1 binding protein 分子名称: Influenza virus NS1A-binding protein 著者 Zhang, K, Shang, G, Padavannil, A, Fontoura, B.M.A, Chook, Y.M. 登録日 2018-11-15 公開日 2018-12-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8JQW	Crystal structure of V30I mutated human transthyretin 分子名称: MAGNESIUM ION, Transthyretin 著者 Mizuguchi, M, Yamada, S, Obita, T. 登録日 2023-06-15 公開日 2024-04-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis. Febs J., 291, 2024
7Q9N	Transthyretin complexed with (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol 分子名称: 4-[(~{E})-2-naphthalen-2-ylethenyl]benzene-1,2-diol, Transthyretin 著者 Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A. 登録日 2021-11-12 公開日 2022-11-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands. Acs Chem Neurosci, 14, 2023
7Q9L	Transthyretin complexed with (E)-4-(2-(naphthalen-1-yl)vinyl)benzene-1,2-diol 分子名称: 4-[(~{E})-2-naphthalen-1-ylethenyl]benzene-1,2-diol, GLYCEROL, SODIUM ION, ... 著者 Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A. 登録日 2021-11-12 公開日 2022-11-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands. Acs Chem Neurosci, 14, 2023
7Q9O	Complex of Transthyretin with resveratrol exhibits multiple binding modes 分子名称: GLYCEROL, RESVERATROL, SODIUM ION, ... 著者 Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A. 登録日 2021-11-12 公開日 2022-11-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands. Acs Chem Neurosci, 14, 2023
7QC5	Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound 分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone, Transthyretin 著者 Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. 登録日 2021-11-22 公開日 2022-11-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. J.Med.Chem., 65, 2022
3SSG	Structure of transthyretin L55P in complex with Zn 分子名称: CACODYLATE ION, Transthyretin, ZINC ION 著者 Castro-Rodrigues, A.F, Gales, L, Damas, A.M. 登録日 2011-07-08 公開日 2011-11-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils. Acta Crystallogr.,Sect.D, 67, 2011
8JOK	Crystal structure of V30L mutated human transthyretin 分子名称: MAGNESIUM ION, Transthyretin 著者 Mizuguchi, M, Yamada, S, Obita, T. 登録日 2023-06-07 公開日 2024-04-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis. Febs J., 291, 2024
8JNU	Crystal structure of V30G mutated human transthyretin 分子名称: MAGNESIUM ION, Transthyretin 著者 Mizuguchi, M, Yamada, S, Obita, T. 登録日 2023-06-06 公開日 2024-04-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis. Febs J., 291, 2024

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