PDB: 1371 件ウェブページステータス検索Chemie searchBIRD

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6A38	MVM NS2 NES in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6A3A	MVM NES mutant Nm2 in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6A3B	MVM NES mutant Nm13 in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6A3C	MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6A3E	MVM NES mutant Nm15 in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6AGP	Structure of Rac1 in the low-affinity state for Mg2+ 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1 著者 Toyama, Y, Kontani, K, Katada, T, Shimada, I. 登録日 2018-08-13 公開日 2019-03-20 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR. Sci Adv, 5, 2019
6AJ4	Crystal structure of the DHR-2 domain of DOCK7 in complex with Cdc42 分子名称: Cell division control protein 42 homolog, Dedicator of cytokinesis protein 7 著者 Kukimoto-Niino, M, Shirouzu, M. 登録日 2018-08-27 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.256 Å) 主引用文献 Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor. Structure, 27, 2019
6AJL	DOCK7 mutant I1836Y complexed with Cdc42 分子名称: Cell division control protein 42 homolog, Dedicator of cytokinesis protein 7 著者 Kukimoto-Niino, M, Shirouzu, M. 登録日 2018-08-28 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor. Structure, 27, 2019
6AMB	Crystal Structure of the Afadin RA1 domain in complex with HRAS 分子名称: Afadin, GTPase HRas, MAGNESIUM ION, ... 著者 Smith, M.J, Ishiyama, N, Ikura, M. 登録日 2017-08-09 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Evolution of AF6-RAS association and its implications in mixed-lineage leukemia. Nat Commun, 8, 2017
6ARK	Crystal Structure of compound 10 covalently bound to K-Ras G12C 分子名称: (3R)-N-(6-bromonaphthalen-2-yl)-3-hydroxy-1-propanoyl-L-prolinamide, GLYCEROL, GTPase KRas, ... 著者 Nnadi, C.I, Jenkins, M.L, Gentile, D.R, Bateman, L.A, Zaidman, D, Balius, T.E, Nomura, D.K, Burke, J.E, Shokat, K.M, London, N. 登録日 2017-08-22 公開日 2018-01-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. J Chem Inf Model, 58, 2018
6ASA	KRAS mutant-D33E in GDP-bound 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Lu, J, Westover, K. 登録日 2017-08-24 公開日 2018-01-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.545 Å) 主引用文献 KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. Biochemistry, 57, 2018
6ASE	KRAS mutant-A59G in GDP-bound 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Westover, K, Lu, J. 登録日 2017-08-24 公開日 2018-01-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.554 Å) 主引用文献 KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. Biochemistry, 57, 2018
6AXF	Structure of RasGRP2 in complex with Rap1B 分子名称: RAS guanyl-releasing protein 2, Ras-related protein Rap-1b 著者 Kondo, Y, Iwig, J.S, Kuriyan, J. 登録日 2017-09-06 公開日 2017-10-11 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife, 6, 2017
6AXG	Structure of RasGRP4 in complex with HRas 分子名称: GTPase HRas, RAS guanyl-releasing protein 4 著者 Kondo, Y, Iwig, J.S, Kuriyan, J. 登録日 2017-09-06 公開日 2017-10-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.302 Å) 主引用文献 A histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife, 6, 2017
6B0V	Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C 分子名称: 1-[3-(4-{[(4,5-dichloro-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]propan-1-one, CALCIUM ION, GTPase KRas, ... 著者 Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. 登録日 2017-09-15 公開日 2018-05-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors. Nat. Struct. Mol. Biol., 25, 2018
6B0Y	Crystal Structure of small molecule ARS-917 covalently bound to K-Ras G12C 分子名称: 1-{4-[6-chloro-7-(2-fluorophenyl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... 著者 Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. 登録日 2017-09-15 公開日 2018-05-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors. Nat. Struct. Mol. Biol., 25, 2018
6BA6	Solution structure of Rap1b/talin complex 分子名称: Ras-related protein Rap-1b, Talin-1 著者 Zhu, L, Yang, J, Qin, J. 登録日 2017-10-12 公開日 2017-12-06 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation. Nat Commun, 8, 2017
6BC0	A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 28, ... 著者 Chen, Z, Sternweis, P.C. 登録日 2017-10-20 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. J. Struct. Biol., 202, 2018
6BC1	A Complex between PH Domain of p190RhoGEF and Activated Rac1 Bound to a GTP Analog 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1, ... 著者 Chen, Z, Sternweis, P.C. 登録日 2017-10-20 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. J. Struct. Biol., 202, 2018
6BCA	A Complex between PH Domain of LbcRhoGEF (AKAP-Lbc) and Activated RhoA Bound to a GTP Analog 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, A-kinase anchor protein 13, MAGNESIUM ION, ... 著者 Sternweis, P.C, Chen, Z. 登録日 2017-10-20 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.995 Å) 主引用文献 Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase. Data Brief, 17, 2018
6BCB	A Complex between PH Domain of p114RhoGEF and Activated RhoA Bound to a GTP Analog 分子名称: 1,2-ETHANEDIOL, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... 著者 Sternweis, P.C, Chen, Z. 登録日 2017-10-20 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.401 Å) 主引用文献 Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase. Data Brief, 17, 2018
6BCU	Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, GTP-binding protein Rheb, ... 著者 Pavletich, N.P, Yang, H. 登録日 2017-10-20 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
6BOF	Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE 著者 Bera, A.K, Yan, W, Westover, K.D. 登録日 2017-11-20 公開日 2019-05-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.401 Å) 主引用文献 Tissue-Specific Oncogenic Activity of KRASA146T. Cancer Discov, 9, 2019
6BP1	Crystal structure of human KRAS A59G mutant in complex with GCP 分子名称: GTPase KRas, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Bera, A.K, Lu, J, Westover, K.D. 登録日 2017-11-21 公開日 2018-01-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. Biochemistry, 57, 2018
6BSX	CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND 1 AT 1.65A RESOLUTION 分子名称: (5,6-dimethyl-1H-benzimidazol-2-yl)methanol, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Mahoney, S.J. 登録日 2017-12-04 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun, 9, 2018

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