PDB: 66724 件ウェブページステータス検索Chemie searchBIRD

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3ZO8	Wild-type chorismate mutase of Bacillus subtilis at 1.6 A resolution 分子名称: CHORISMATE MUTASE AROH 著者 Burschowsky, D, vanEerde, A, Okvist, M, Kienhofer, A, Kast, P, Hilvert, D, Krengel, U. 登録日 2013-02-20 公開日 2014-04-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Electrostatic Transition State Stabilization Rather Than Reactant Destabilization Provides the Chemical Basis for Efficient Chorismate Mutase Catalysis. Proc.Natl.Acad.Sci.USA, 111, 2014
3HMN	Crystal structure of human Mps1 catalytic domain in complex with ATP 分子名称: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity protein kinase TTK 著者 Chu, M.L.H, Chavas, L.M.G, Williams, D.H, Tabernero, L, Eyers, P.A. 登録日 2009-05-29 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes. Biochemistry, 49, 2010
3ZU5	Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH and the 2-pyridone inhibitor PT173 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one, PUTATIVE REDUCTASE YPO4104/Y4119/YP_4011, ... 著者 Hirschbeck, M.W, Kuper, J, Tonge, P.J, Kisker, C. 登録日 2011-07-13 公開日 2012-01-18 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the Yersinia Pestis Fabv Enoyl-Acp Reductase and its Interaction with Two 2-Pyridone Inhibitors Structure, 20, 2012
4H6T	Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A 分子名称: PHOSPHATE ION, Prothrombin 著者 Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. 登録日 2012-09-19 公開日 2013-03-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Autoactivation of thrombin precursors. J.Biol.Chem., 288, 2013
4H95	Candida albicans dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine (UCP1006) 分子名称: 6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, Dihydrofolate Reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Paulsen, J.L, Anderson, A.C. 登録日 2012-09-24 公開日 2013-03-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorg.Med.Chem.Lett., 23, 2013
4B7V	Structure of wild type Pseudomonas aeruginosa FabF (KASII) 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2, POTASSIUM ION 著者 Lecker, L, Baum, B, Zoltner, M, Hunter, W.N. 登録日 2012-08-22 公開日 2013-09-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form Acta Crystallogr.,Sect.F, 71, 2015
3KM3	Crystal structure of eoxycytidine triphosphate deaminase from anaplasma phagocytophilum at 2.1A resolution 分子名称: Deoxycytidine triphosphate deaminase, IODIDE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-11-09 公開日 2009-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 SAD phasing using iodide ions in a high-throughput structural genomics environment. J.Struct.Funct.Genom., 12, 2011
3KM8	Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine 分子名称: 9-DEAZAINOSINE, Adenosine deaminase, ZINC ION 著者 Fan, X, Gao, Y. 登録日 2009-11-10 公開日 2010-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Catalytic Mechanism of Adenosine Deaminase from Mouse: An Experimental and Theoretical Study To be Published
6V23	Ligand-free L-aspraginase II from E. coli (EcAII) 分子名称: L-asparaginase 2 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-11-22 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Mechanism of Catalysis by l-Asparaginase. Biochemistry, 59, 2020
4AWQ	Complex of HSP90 ATPase domain with tropane derived inhibitors 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-benzyl-6-[(3-endo)-3-{[(3-methoxy-2-methylphenyl)carbonyl]amino}-8-azabicyclo[3.2.1]oct-8-yl]pyridine-3-carboxamide 著者 Lougheed, J.C, Stout, T.J. 登録日 2012-06-05 公開日 2012-08-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of Xl888: A Novel Tropane-Derived Small Molecule Inhibitor of Hsp90. Bioorg.Med.Chem.Lett., 22, 2012
4BBF	Aminoalkylpyrimidine Inhibitor Complexes with JAK2 分子名称: (2R)-N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide, TYROSINE-PROTEIN KINASE JAK2 著者 Li, J. 登録日 2012-09-21 公開日 2012-11-21 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors Bioorg.Med.Chem.Lett., 22, 2012
6PT6	Crystal structure of PsS1_NC C84S in complex with i-neocarratetraose 分子名称: 3,6-anhydro-2-O-sulfo-alpha-D-galactopyranose-(1-3)-4-O-sulfo-beta-D-galactopyranose, CALCIUM ION, exo-2S-iota carrageenan S1 sulfatase 著者 Hettle, A.G, Boraston, A.B. 登録日 2019-07-15 公開日 2019-09-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Insights into the kappa / iota-carrageenan metabolism pathway of some marinePseudoalteromonasspecies. Commun Biol, 2, 2019
4K3Q	E. coli sliding clamp in complex with AcQLDAF 分子名称: (ACE)QLDAF, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Yin, Z, Oakley, A.J. 登録日 2013-04-11 公開日 2013-05-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp J.Med.Chem., 56, 2013
6V28	Complex of double mutant (T89V,K162T) of E. coli L-asparaginase II with L-Asp 分子名称: GLYCEROL, IMIDAZOLE, L-asparaginase 2 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-11-22 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mechanism of Catalysis by l-Asparaginase. Biochemistry, 59, 2020
3I46	Crystal structure of beta toxin from Staphylococcus aureus F277A, P278A mutant with bound calcium ions 分子名称: Beta-hemolysin, CALCIUM ION, CHLORIDE ION 著者 Huseby, M, Shi, K, Kruse, A.C, Ohlendorf, D.H. 登録日 2009-07-01 公開日 2010-07-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and biological functions of beta toxin from Staphylococcus aureus: Role of the hydrophobic beta hairpin in virulence To be Published
4K8W	An arm-swapped dimer of the S. pyogenes pilin specific assembly factor SipA 分子名称: 1,2-ETHANEDIOL, ETHANOL, LepA 著者 Young, P.G, Kang, H.J, Baker, E.N. 登録日 2013-04-19 公開日 2013-06-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA. J.Struct.Biol., 183, 2013
4KDV	Crystal structure of a bacterial immunoglobulin-like domain from the M. primoryensis ice-binding adhesin 分子名称: Antifreeze protein, CALCIUM ION 著者 Guo, S, Garnham, C.P, Karunan, S.P, Campbell, R.L, Allingham, J.S, Davies, P.L. 登録日 2013-04-25 公開日 2013-10-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Role of Ca(2+) in folding the tandem beta-sandwich extender domains of a bacterial ice-binding adhesin. Febs J., 280, 2013
4A41	CpGH89CBM32-5, from Clostridium perfringens, in complex with galactose 分子名称: ALPHA-N-ACETYLGLUCOSAMINIDASE FAMILY PROTEIN, CALCIUM ION, SODIUM ION, ... 著者 Ficko-Blean, E, Stuart, C.P, Suits, M.D, Cid, M, Tessier, M, Woods, R.J, Boraston, A.B. 登録日 2011-10-06 公開日 2012-04-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Carbohydrate Recognition by an Architecturally Complex Alpha-N-Acetylglucosaminidase from Clostridium Perfringens. Plos One, 7, 2012
4KM3	Discovery of a novel structural motif in methionine aminopeptidase from Streptococci with possible post-translational modification 分子名称: Methionine aminopeptidase 著者 Arya, T, Addlagatta, A. 登録日 2013-05-08 公開日 2014-01-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization. Plos One, 8, 2013
3I0E	Crystal structure of GTB C80S/C196S + H-antigen 分子名称: ABO glycosyltransferase, alpha-L-fucopyranose-(1-2)-hexyl beta-D-galactopyranoside 著者 Schuman, B, Persson, M, Landry, R.C, Polakowski, R, Weadge, J.T, Seto, N.O.L, Borisova, S, Palcic, M.M, Evans, S.V. 登録日 2009-06-25 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding J.Mol.Biol., 402, 2010
3I0L	Crystal structure of GTB C80S/C196S/C209S + DA + UDP-Gal 分子名称: ABO glycosyltransferase, URIDINE-5'-DIPHOSPHATE, alpha-L-fucopyranose-(1-2)-hexyl beta-D-galactopyranoside, ... 著者 Schuman, B, Persson, M, Landry, R.C, Polakowski, R, Weadge, J.T, Seto, N.O.L, Borisova, S, Palcic, M.M, Evans, S.V. 登録日 2009-06-25 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding J.Mol.Biol., 402, 2010
3HOJ	Crystal Structure of a Novel Engineered Retroaldolase: RA-22 分子名称: RETROALDOLASE-22 著者 Stoddard, B.L, Doyle, L.A. 登録日 2009-06-02 公開日 2009-08-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 De Novo Computational Design of Retro-Aldol Enzymes Science, 319, 2008
6S39	Fragment AZ-018 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-06-24 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
3I69	Apo Glutathione Transferase A1-1 GIMF-helix mutant 分子名称: GLUTATHIONE, Glutathione S-transferase A1 著者 Balogh, L.M, Le Trong, I, Stenkamp, R.E, Atkins, W.M. 登録日 2009-07-06 公開日 2009-09-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry, 48, 2009
6V2A	Complex of double mutant (T89V,K162T) of E. coli L-asparaginase II with L-Asn 分子名称: ASPARAGINE, L-asparaginase 2 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-11-22 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanism of Catalysis by l-Asparaginase. Biochemistry, 59, 2020

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