PDB: 66724 件ウェブページステータス検索Chemie searchBIRD

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3VZN	Crystal structure of the Bacillus circulans endo-beta-(1,4)-xylanase (BcX) N35E mutant with Glu78 covalently bonded to 2-deoxy-2-fluoro-xylobiose 分子名称: Endo-1,4-beta-xylanase, SULFATE ION, beta-D-xylopyranose-(1-4)-1,5-anhydro-2-deoxy-2-fluoro-D-xylitol 著者 Ludwiczek, M.L, D'Angelo, I, Yalloway, G.N, Okon, M, Nielsen, J.E, Strynadka, N.C, Withers, S.G, McIntosh, L.P. 登録日 2012-10-15 公開日 2013-05-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase Biochemistry, 52, 2013
3HPX	Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644) 分子名称: 2-isopropylmalate synthase, GLYCEROL, NICKEL (II) ION 著者 Koon, N, Squire, C.J, Baker, E.N. 登録日 2009-06-05 公開日 2010-05-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding Biochemistry, 51, 2012
4H6S	Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A 分子名称: Prothrombin, SODIUM ION 著者 Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. 登録日 2012-09-19 公開日 2013-03-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Autoactivation of thrombin precursors. J.Biol.Chem., 288, 2013
6PA2	E. coli L-asparaginase II mutant (K162M) in complex with L-Asp at pH 5.6 分子名称: ASPARTIC ACID, GLYCEROL, L-asparaginase 2 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-06-11 公開日 2019-09-04 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase. Protein Sci., 28, 2019
3I1J	Structure of a putative short chain dehydrogenase from Pseudomonas syringae 分子名称: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... 著者 Singer, A.U, Evdokimova, E, Kudritska, M, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-06-26 公開日 2009-07-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of a putative short chain dehydrogenase from Pseudomonas syringae To be Published
3I4Q	Structure of a putative inorganic pyrophosphatase from the oil-degrading bacterium Oleispira antarctica 分子名称: APC40078, SODIUM ION 著者 Singer, A.U, Evdokimova, E, Kagan, O, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-07-02 公開日 2009-07-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica. Nat Commun, 4, 2013
3I05	Tryptophanyl-tRNA synthetase from Trypanosoma brucei 分子名称: Tryptophanyl-tRNA synthetase 著者 Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) 登録日 2009-06-24 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011
3I0K	Crystal structure of GTB C80S/C196S/C209S + UDP + H antigen 分子名称: ABO glycosyltransferase, URIDINE-5'-DIPHOSPHATE, alpha-L-fucopyranose-(1-2)-hexyl beta-D-galactopyranoside 著者 Schuman, B, Persson, M, Landry, R.C, Polakowski, R, Weadge, J.T, Seto, N.O.L, Borisova, S, Palcic, M.M, Evans, S.V. 登録日 2009-06-25 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding J.Mol.Biol., 402, 2010
3I4I	Crystal structure of a prokaryotic beta-1,3-1,4-glucanase (lichenase) derived from a mouse hindgut metagenome 分子名称: 1,3-1,4-beta-glucanase, CALCIUM ION 著者 Nakatani, Y, Nalder, T.D, Tannock, G.W, Cutfield, J.F, Jack, R.W, Carne, A. 登録日 2009-07-01 公開日 2010-07-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal structure of a prokaryotic beta-1,3-1,4-glucanase (lichenase) derived from a mouse hindgut metagenome To be Published
4HFP	Structure of thrombin mutant S195a bound to the active site inhibitor argatroban 分子名称: (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid, Prothrombin, SODIUM ION 著者 Pozzi, N, Chen, Z, Zapata, F, Lin, W, Barranco-Medina, S, Pelc, L.A, Di Cera, E. 登録日 2012-10-05 公開日 2013-03-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Autoactivation of thrombin precursors. J.Biol.Chem., 288, 2013
3HOP	Structure of the actin-binding domain of human filamin A 分子名称: Filamin-A, PHOSPHATE ION 著者 Clark, A.R, Sawyer, G.M, Robertson, S.P, Sutherland-Smith, A.J. 登録日 2009-06-03 公開日 2009-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders Hum.Mol.Genet., 18, 2009
3HQ1	Crystal structure of Mycobacterium tuberculosis LeuA complexed with citrate and Mn2+ 分子名称: 2-isopropylmalate synthase, CHLORIDE ION, CITRATE ANION, ... 著者 Koon, N, Squire, C.J, Baker, E.N. 登録日 2009-06-05 公開日 2010-05-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Probing the active site of M. tuberculosis LeuA To be Published
3VG2	Iodide derivative of human LFABP 分子名称: Fatty acid-binding protein, liver, IODIDE ION, ... 著者 Sharma, A, Yogavel, M, Sharma, A. 登録日 2011-08-03 公開日 2012-06-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Utility of anion and cation combinations for phasing of protein structures. J.Struct.Funct.Genom., 13, 2012
3VMO	Crystal structure of dextranase from Streptococcus mutans in complex with isomaltotriose 分子名称: Dextranase, PHOSPHATE ION, alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose, ... 著者 Suzuki, N, Fujimoto, Z, Kim, Y.M, Momma, M, Okuyama, M, Mori, H, Funane, K, Kimura, A. 登録日 2011-12-14 公開日 2012-02-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural elucidation of dextran degradation mechanism by streptococcus mutans dextranase belonging to glycoside hydrolase family 66 J.Biol.Chem., 287, 2012
3HPK	Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 分子名称: GLYCEROL, PRKCA-binding protein,9-mer peptide of THE GLUR2 SUBUNIT 著者 Yu, J, Shi, Y, Zhang, M. 登録日 2009-06-04 公開日 2010-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Redox-Regulated Lipid Membrane Binding of the PICK1 PDZ Domain. Biochemistry, 49, 2010
3VV8	Crystal structure of beta secetase in complex with 2-amino-3-methyl-6-((1S,2R)-2-(3'-methylbiphenyl-4-yl)cyclopropyl)pyrimidin-4(3H)-one 分子名称: 2-amino-3-methyl-6-[(1S,2R)-2-(3'-methylbiphenyl-4-yl)cyclopropyl]pyrimidin-4(3H)-one, Beta-secretase 1, GLYCEROL 著者 Yonezawa, S, Yamamoto, T, Yamakawa, H, Muto, C, Hosono, M, Hattori, K, Higashino, K, Sakagami, M, Togame, H, Tanaka, Y, Nakano, T, Takemoto, H, Arisawa, M, Shuto, S. 登録日 2012-07-17 公開日 2012-10-24 最終更新日 2013-09-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Conformational restriction approach to beta-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode. J.Med.Chem., 55, 2012
3W1F	Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide 分子名称: 5-[5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl]-2-methylbenzenesulfonamide, Dual specificity protein kinase TTK 著者 Kusakabe, K, Ide, N, Daigo, Y, Tachibana, Y, Itoh, T, Yamamoto, T, Hashizume, H, Hato, Y, Higashino, K, Okano, Y, Sato, Y, Inoue, M, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Kido, Y, Sakamoto, S, Yasuo, K, Maeda, M, Higaki, M, Ueda, K, Yoshizawa, H, Baba, Y, Shiota, T, Murai, H, Nakamura, Y. 登録日 2012-11-14 公開日 2013-06-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125) J.Med.Chem., 56, 2013
3IHZ	Crystal structure of the FK506 binding domain of Plasmodium vivax FKBP35 in complex with FK506 分子名称: 70 kDa peptidylprolyl isomerase, putative, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN 著者 Qureshi, I.A, Alag, R, Yoon, H.S, Lescar, J. 登録日 2009-07-31 公開日 2010-06-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35 Protein Sci., 19, 2010
3VID	Crystal structure of human VEGFR2 kinase domain with Compound A. 分子名称: 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole, Vascular endothelial growth factor receptor 2 著者 Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H. 登録日 2011-09-29 公開日 2012-08-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3, 2012
3VG5	Barium derivative of human LFABP 分子名称: BARIUM ION, Fatty acid-binding protein, liver, ... 著者 Sharma, A, Yogavel, M, Sharma, A. 登録日 2011-08-03 公開日 2012-06-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Utility of anion and cation combinations for phasing of protein structures. J.Struct.Funct.Genom., 13, 2012
3IWY	Crystal structure of human MDM2 complexed with D-peptide (12 residues) 分子名称: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 著者 Pazgier, M, Lu, W. 登録日 2009-09-03 公開日 2010-04-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398, 2010
4HKP	Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide 分子名称: 5-hydroxycytidine 5'-(dihydrogen phosphate), GLYCEROL, N-hydroxycytidine 5'-(dihydrogen phosphate), ... 著者 To, T.K, Kotra, L.P, Pai, E.F. 登録日 2012-10-15 公開日 2012-11-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. J.Med.Chem., 55, 2012
6T38	Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BROMIDE ION, CHLORIDE ION, ... 著者 Alphey, M.S, Xiao, G, Westwood, J.N. 登録日 2019-10-10 公開日 2020-08-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorg.Med.Chem., 50, 2021
3VNA	Structural insights into small RNA sorting and mRNA binding by Arabidopsis Ago Mid domains 分子名称: Protein argonaute 1, SULFATE ION 著者 Yuan, Y.A, Zha, X. 登録日 2012-01-11 公開日 2012-10-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insights into small RNA sorting and mRNA target binding by Arabidopsis Argonaute Mid domains Febs Lett., 586, 2012
4HO1	The Crystal structure of Haemophilus influenzae O-acetylserine sulfhydrylase at 1.85A resolution 分子名称: 1,2-ETHANEDIOL, Cysteine synthase, GLYCEROL 著者 Banerjee, S, Singh, A.K, Kumaran, S. 登録日 2012-10-22 公開日 2013-11-13 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.856 Å) 主引用文献 The Crystal structure of Haemophilus influenzae O-acetylserine sulfhydrylase at 1.85A resolution TO BE PUBLISHED

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