PDB: 1147 件ウェブページステータス検索Chemie searchBIRD

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4PM1	Human transthyretin (TTR) complexed with 16-alpha-bromo-estradiol 分子名称: (14beta,16alpha,17alpha)-16-bromoestra-1,3,5(10)-triene-3,17-diol, 1,2-ETHANEDIOL, Transthyretin 著者 Stura, E.A, Ciccone, L. 登録日 2014-05-20 公開日 2014-10-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
4PMF	Human transthyretin (TTR) complexed with curcumin 分子名称: (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, SODIUM ION, ... 著者 Stura, E.A, Ciccone, L. 登録日 2014-05-21 公開日 2014-10-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
5OQ0	Crystal structure of transthyretin mutant 87-110-117 分子名称: Transthyretin 著者 Zanotti, G, Vallese, F, Berni, R. 登録日 2017-08-10 公開日 2017-12-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structural and dynamics evidence for scaffold asymmetric flexibility of the human transthyretin tetramer. PLoS ONE, 12, 2017
5IHH	Crystal structure of human transthyretin in complex with luteolin-MeO at 1.35 A resolution 分子名称: 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-chromen-4-one, SODIUM ION, Transthyretin 著者 Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E. 登録日 2016-02-29 公開日 2016-04-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. Plos One, 11, 2016
4WCD	Trypanosoma brucei PTR1 in complex with inhibitor 10 分子名称: 5-(1H-benzotriazol-6-yl)-1,3,4-thiadiazol-2-amine, ACETATE ION, GLYCEROL, ... 著者 Mangani, S, Di Pisa, F, Pozzi, C. 登録日 2014-09-04 公開日 2015-09-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
5A6I	V122I Transthyretin structure in complex with Tolcalpone 分子名称: TRANSTHYRETIN, Tolcapone 著者 Reverter, D, Gallego, P, Santana, R, Ventura, S. 登録日 2015-06-26 公開日 2016-02-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7, 2016
5AL8	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: daidzein-7-O- glucuronide 分子名称: DAIDZEIN-7-O-GLUCURONIDE, TRANSTHYRETIN 著者 Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. 登録日 2015-03-06 公開日 2015-10-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AKS	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-3-O- glucuronide 分子名称: DIMETHYL SULFOXIDE, Resveratrol-3-O-glucuronide, SULFATE ION, ... 著者 Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. 登録日 2015-03-05 公開日 2015-10-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AKT	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-4'-O- glucuronide 分子名称: Resveratrol-4'-O-glucuronide, SULFATE ION, TRANSTHYRETIN 著者 Florio, P, Folli, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. 登録日 2015-03-05 公開日 2015-10-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AL0	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-3-O-sulfate 分子名称: DIMETHYL SULFOXIDE, RESVERATROL-3-O-SULFATE, SULFATE ION, ... 著者 Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. 登録日 2015-03-05 公開日 2015-10-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.388 Å) 主引用文献 Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AKV	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: genistein-7-O- glucuronide 分子名称: Genistein-7-O-glucuronide, TRANSTHYRETIN 著者 Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. 登録日 2015-03-05 公開日 2015-10-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
7ACU	Crystal structure of human transthyretin in complex with Benzbromarone 分子名称: Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone 著者 Leite, J.P, Gales, L. 登録日 2020-09-11 公開日 2020-10-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.541 Å) 主引用文献 Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer. Int J Mol Sci, 21, 2020
7ZIR	Cryo-EM structure of hnRNPDL amyloid fibrils 分子名称: Heterogeneous nuclear ribonucleoprotein D-like 著者 Garcia-Pardo, J, Chaves-Sanjuan, A, Bartolome-Nafria, A, Gil-Garcia, M, Visentin, C, Bolognesi, M, Ricagno, S, Ventura, S. 登録日 2022-04-08 公開日 2022-12-28 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Nat Commun, 14, 2023
7THA	Crystal structure of human transthyretin variant C10A/M13V 分子名称: CALCIUM ION, Transthyretin 著者 Jaeger, M, Mortenson, D.E, Yan, N.L, Kelly, J.W. 登録日 2022-01-10 公開日 2023-04-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Lysine carbamylation competes with urea unfolding of human transthyretin introducing kinetic heterogeneity To Be Published
6XTK	Y114C Transthyretin structure in complex with Tolcalpone 分子名称: Tolcapone, Transthyretin 著者 Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. 登録日 2020-01-16 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
3CN2	Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxybiphenyl 分子名称: 3,5-dibromobiphenyl-4-ol, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2008-03-24 公開日 2008-10-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
3CFN	Crystal structure of human transthyretin in complex with 1-anilino-8-naphthalene sulfonate 分子名称: 8-ANILINO-1-NAPHTHALENE SULFONATE, Transthyretin 著者 Lima, L.-M.T.R, Foguel, D, Polikarpov, I. 登録日 2008-03-04 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
9B1R	Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 from Arabidopsis thaliana 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1 著者 Park, H, Youn, B, Park, D.J, Puthanveettil, S.V, Kang, C. 登録日 2024-03-13 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana. Sci Rep, 14, 2024
3CFT	Crystal structure of human transthyretin in complex with 1-amino-5-naphthalene sulfonate 分子名称: 5-aminonaphthalene-1-sulfonic acid, Transthyretin 著者 Lima, L.-M.T.R, Foguel, D, Polikarpov, I. 登録日 2008-03-04 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
3CN0	Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene 分子名称: 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2008-03-24 公開日 2008-10-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
7OB4	Cryo-EM structure of a twisted-dimer transthyretin amyloid fibril from vitreous body of the eye 分子名称: Transthyretin 著者 Iakovleva, I, Sauer-Eriksson, A.E. 登録日 2021-04-21 公開日 2021-12-15 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.22 Å) 主引用文献 Structural basis for transthyretin amyloid formation in vitreous body of the eye. Nat Commun, 12, 2021
3CFM	Crystal structure of the apo form of human wild-type transthyretin 分子名称: Transthyretin 著者 Lima, L.-M.T.R, Foguel, D, Polikarpov, I. 登録日 2008-03-04 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
3D2T	Human transthyretin (ttr) complexed with diflunisal 分子名称: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin 著者 Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C. 登録日 2008-05-08 公開日 2008-05-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J.Med.Chem., 47, 2004
3CN1	Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxystilbene 分子名称: 2,6-dibromo-4-[(E)-2-phenylethenyl]phenol, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2008-03-24 公開日 2008-10-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
3DGD	Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 分子名称: ACETATE ION, GLYCEROL, Transthyretin, ... 著者 Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. 登録日 2008-06-13 公開日 2008-07-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.383 Å) 主引用文献 Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010

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