7ZII
 
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-193 | | 分子名称: | 8-(5~{H}-[1,3]dioxolo[4,5-f]benzimidazol-6-ylmethyl)-7-(phenylmethyl)-3-propyl-purine-2,6-dione, FE (III) ION, GLYCEROL, ... | | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | 登録日 | 2022-04-08 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.6280005 Å) | | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
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7ZIJ
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-080 | | 分子名称: | 8-(1~{H}-benzimidazol-2-ylmethyl)-3-cyclopropyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | 登録日 | 2022-04-08 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.94678366 Å) | | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
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7ZIG
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-060 | | 分子名称: | (2~{R})-2-azanyl-5-[[2-[[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]methyl]-1~{H}-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 | | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | 登録日 | 2022-04-08 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.808885 Å) | | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
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7ZIF
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-480 | | 分子名称: | (2R)-2-azanyl-5-[[2-[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]sulfanyl-3H-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, GLYCEROL, ... | | 著者 | Schuetz, A, Ziebart, N, Weise, M, Mallow, K, Pfeifer, J, Nazare, M, Specker, E, Heinemann, U. | | 登録日 | 2022-04-08 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.86859715 Å) | | 主引用文献 | Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
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1LTZ
 | | CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE HAS BOUND IRON (III) AND OXIDIZED COFACTOR 7,8-DIHYDROBIOPTERIN | | 分子名称: | 7,8-DIHYDROBIOPTERIN, CHLORIDE ION, FE (III) ION, ... | | 著者 | Erlandsen, H, Kim, J.Y, Patch, M.G, Han, A, Volner, A, Abu-Omar, M.M, Stevens, R.C. | | 登録日 | 2002-05-21 | | 公開日 | 2002-07-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
J.Mol.Biol., 320, 2002
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1KW0
 | | Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, BETA(2-THIENYL)ALANINE, FE (II) ION, ... | | 著者 | Andersen, O.A, Flatmark, T, Hough, E. | | 登録日 | 2002-01-28 | | 公開日 | 2003-01-28 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the Ternary Complex of the Catalytic
Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin
and 3-(2-thienyl)-L-alanine, and its Implications for the Mechanism
of Catalysis and Substrate Activation
J.Mol.Biol., 320, 2002
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1LRM
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1LTV
 | | CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE WITH BOUND OXIDIZED Fe(III) | | 分子名称: | FE (III) ION, PHENYLALANINE-4-HYDROXYLASE | | 著者 | Erlandsen, H, Kim, J.Y, Patch, M.G, Han, A, Volner, A, Abu-Omar, M.M, Stevens, R.C. | | 登録日 | 2002-05-20 | | 公開日 | 2002-07-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
J.Mol.Biol., 320, 2002
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1LTU
 | | CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM, APO (NO IRON BOUND) STRUCTURE | | 分子名称: | PHENYLALANINE-4-HYDROXYLASE | | 著者 | Erlandsen, H, Kim, J.Y, Patch, M.G, Han, A, Volner, A, Abu-Omar, M.M, Stevens, R.C. | | 登録日 | 2002-05-20 | | 公開日 | 2002-07-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
J.Mol.Biol., 320, 2002
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1J8T
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1MMK
 | | Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase ((FeII)) complexed with tetrahydrobiopterin and thienylalanine | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, BETA(2-THIENYL)ALANINE, FE (II) ION, ... | | 著者 | Andersen, O.A, Flatmark, T, Hough, E. | | 登録日 | 2002-09-04 | | 公開日 | 2003-09-04 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding
J.Mol.Biol., 333, 2003
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1MLW
 | | Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III) | | 分子名称: | 7,8-DIHYDROBIOPTERIN, FE (III) ION, Tryptophan 5-monooxygenase | | 著者 | Wang, L, Erlandsen, H, Haavik, J, Knappskog, P.M, Stevens, R.C. | | 登録日 | 2002-08-31 | | 公開日 | 2002-12-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin
Biochemistry, 41, 2002
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1MMT
 | | Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase (Fe(II)) complexed with tetrahydrobiopterin and norleucine | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, FE (II) ION, NORLEUCINE, ... | | 著者 | Andersen, O.A, Flatmark, T, Hough, E. | | 登録日 | 2002-09-04 | | 公開日 | 2003-09-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding
J.Mol.Biol., 333, 2003
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1J8U
 | | Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, FE (II) ION, PHENYLALANINE-4-HYDROXYLASE | | 著者 | Andersen, O.A, Flatmark, T, Hough, E. | | 登録日 | 2001-05-22 | | 公開日 | 2002-05-22 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin.
J.Mol.Biol., 314, 2001
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7PIM
 | | Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine. | | 分子名称: | FE (III) ION, L-DOPAMINE, Regulatory domain alpha-helix, ... | | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | | 登録日 | 2021-08-20 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
Nat Commun, 13, 2022
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5DEN
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6N1K
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5EGQ
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1PHZ
 | | STRUCTURE OF PHOSPHORYLATED PHENYLALANINE HYDROXYLASE | | 分子名称: | FE (III) ION, PROTEIN (PHENYLALANINE HYDROXYLASE) | | 著者 | Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. | | 登録日 | 1998-11-11 | | 公開日 | 1999-04-30 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis of autoregulation of phenylalanine hydroxylase.
Nat.Struct.Biol., 6, 1999
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6HYC
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2PHM
 | | STRUCTURE OF PHENYLALANINE HYDROXYLASE DEPHOSPHORYLATED | | 分子名称: | FE (III) ION, PROTEIN (PHENYLALANINE-4-HYDROXYLASE) | | 著者 | Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. | | 登録日 | 1998-11-11 | | 公開日 | 1999-04-30 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis of autoregulation of phenylalanine hydroxylase.
Nat.Struct.Biol., 6, 1999
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5FGJ
 | | Structure of tetrameric rat phenylalanine hydroxylase, residues 1-453 | | 分子名称: | FE (III) ION, MAGNESIUM ION, Phenylalanine-4-hydroxylase | | 著者 | Taylor, A.B, Roberts, K.M, Fitzpatrick, P.F. | | 登録日 | 2015-12-20 | | 公開日 | 2016-05-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering.
J.Am.Chem.Soc., 138, 2016
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6HPO
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6ZVP
 | | Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms | | 分子名称: | FE (III) ION, L-DOPAMINE, Tyrosine 3-monooxygenase | | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | | 登録日 | 2020-07-27 | | 公開日 | 2021-11-17 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
Nat Commun, 13, 2022
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7A2G
 | | Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH). | | 分子名称: | FE (III) ION, Tyrosine 3-monooxygenase | | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Flydal, M.I, Martinez, A, Valpuesta, J.M. | | 登録日 | 2020-08-17 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
Nat Commun, 13, 2022
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