PDB: 7816 件ウェブページステータス検索Chemie searchBIRD

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3KBZ	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 6 分子名称: Fructose-1,6-bisphosphatase 1, {[(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid 著者 Takahashi, M, Sone, J, Hanzawa, H. 登録日 2009-10-20 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3KC1	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 19a 分子名称: Fructose-1,6-bisphosphatase 1, {[(7-carbamoyl-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid 著者 Takahashi, M, Sone, J, Hanzawa, H. 登録日 2009-10-20 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3KGU	Wild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.5 分子名称: GENISTEIN, Transthyretin 著者 Trivella, D.B, Polikarpov, I. 登録日 2009-10-29 公開日 2010-03-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J.Struct.Biol., 170, 2010
3J4S	Helical Model of TubZ-Bt four-stranded filament 分子名称: FtsZ/tubulin-related protein, GUANOSINE-5'-DIPHOSPHATE 著者 Montabana, E.A, Agard, D.A. 登録日 2013-10-03 公開日 2014-02-19 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 111, 2014
3J4T	Helical model of TubZ-Bt two-stranded filament 分子名称: FtsZ/tubulin-related protein 著者 Agard, D.A, Montabana, E.A. 登録日 2013-10-04 公開日 2014-02-19 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (10.8 Å) 主引用文献 Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 111, 2014
3JXU	Crystal structure of the human 70kDa heat shock protein 1A (Hsp70-1) ATPase domain in complex with ADP and inorganic phosphate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1, MAGNESIUM ION, ... 著者 Wisniewska, M.M, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kraulis, P, Kotenyova, T, Kotzsch, A, Markova, N, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Siponen, M.I, Schutz, P, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC) 登録日 2009-09-21 公開日 2009-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 Plos One, 5, 2010
3K1R	Structure of harmonin NPDZ1 in complex with the SAM-PBM of Sans 分子名称: Harmonin, Usher syndrome type-1G protein 著者 Pan, L, Yan, J, Zhang, M. 登録日 2009-09-28 公開日 2010-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins Proc.Natl.Acad.Sci.USA, 107, 2010
3KHF	The crystal structure of the PDZ domain of human Microtubule Associated Serine/Threonine Kinase 3 (MAST3) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Microtubule-associated serine/threonine-protein kinase 3 著者 Roos, A, Elkins, J, Savitsky, P, Wang, J, Ugochukwu, E, Murray, J, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2009-10-30 公開日 2009-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The crystal structure of the PDZ domain of human Microtubule Associated Serine/Threonine Kinase 3 (MAST3) To be Published
3KJ2	Mcl-1 in complex with Bim BH3 mutant F4aE 分子名称: ACETATE ION, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ... 著者 Fire, E, Grant, R.A, Keating, A.E. 登録日 2009-11-02 公開日 2010-02-16 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (2.351 Å) 主引用文献 Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
3KJO	Crystal Structure of hPOT1V2-dTrUd(AGGGTTAG) 分子名称: DNA/RNA (5'-D(*T)-R(P*U)-D(P*AP*GP*GP*GP*TP*TP*AP*G)-3'), Protection of telomeres protein 1 著者 Nandakumar, J, Cech, T.R, Podell, E.R. 登録日 2009-11-03 公開日 2010-01-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc.Natl.Acad.Sci.USA, 107, 2010
3KGA	Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor 分子名称: 6-{3-amino-1-[3-(1H-indol-6-yl)phenyl]-1H-pyrazol-4-yl}-3,4-dihydroisoquinolin-1(2H)-one, MAGNESIUM ION, MAP kinase-activated protein kinase 2 著者 Kroemer, M, Velcicky, J, Izaac, A, Be, C, Huppertz, C, Pflieger, D, Schlapbach, A, Scheufler, C. 登録日 2009-10-28 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy. Bioorg.Med.Chem.Lett., 20, 2010
3KDF	X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression 分子名称: 1,2-ETHANEDIOL, Replication protein A 14 kDa subunit, Replication protein A 32 kDa subunit 著者 Burgie, E.S, Bingman, C.A, Phillips Jr, G.N, Fox, B.G, Makino, S.-I, Center for Eukaryotic Structural Genomics (CESG) 登録日 2009-10-22 公開日 2009-12-01 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (1.975 Å) 主引用文献 X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression To be Published
3KGT	V30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.5 分子名称: GENISTEIN, Transthyretin 著者 Trivella, D.B, Polikarpov, I. 登録日 2009-10-29 公開日 2010-03-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J.Struct.Biol., 170, 2010
3KGS	V30M mutant human transthyretin (TTR) (apoV30M) pH 7.5 分子名称: Transthyretin 著者 Trivella, D.B, Polikarpov, I. 登録日 2009-10-29 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J.Struct.Biol., 170, 2010
3JVR	Characterization of the Chk1 allosteric inhibitor binding site 分子名称: (1S)-1-(1H-benzimidazol-2-yl)ethyl (3,4-dichlorophenyl)carbamate, Serine/threonine-protein kinase Chk1 著者 Chen, P. 登録日 2009-09-17 公開日 2009-10-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Characterization of the CHK1 allosteric inhibitor binding site. Biochemistry, 48, 2009
3JXF	CA-like domain of human PTPRZ 分子名称: Receptor-type tyrosine-protein phosphatase zeta 著者 Bouyain, S. 登録日 2009-09-19 公開日 2009-12-22 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Proc.Natl.Acad.Sci.USA, 107, 2010
3JT0	Crystal Structure of the C-terminal fragment (426-558) Lamin-B1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR5546A 分子名称: Lamin-B1 著者 Kuzin, A, Abashidze, M, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Belote, R.L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2009-09-11 公開日 2009-09-22 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (2.392 Å) 主引用文献 Northeast Structural Genomics Consortium Target HR5546A To be Published
3K9B	Crystal structure of human liver carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF) 分子名称: Liver carboxylesterase 1, cyclohexyl (S)-methylphosphonofluoridoate 著者 Hemmert, A.C, Redinbo, M.R. 登録日 2009-10-15 公開日 2010-01-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Mol.Pharmacol., 77, 2010
3JYA	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors 分子名称: 6,9-dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one, Proto-oncogene serine/threonine-protein kinase Pim-1 著者 Stoll, V.S. 登録日 2009-09-21 公開日 2009-11-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors TO BE PUBLISHED
3K77	X-ray crystal structure of XRCC1 分子名称: DNA repair protein XRCC1 著者 Cuneo, M.J, London, R.E. 登録日 2009-10-12 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.597 Å) 主引用文献 Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase beta binding affinity. Proc.Natl.Acad.Sci.USA, 107, 2010
3K7V	Protein phosphatase 2A core complex bound to dinophysistoxin-1 分子名称: (2R)-3-[(2S,5R,6R,8S)-8-{(1R,2E)-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-6'-{(1S,3S)-3-[(2S,3R,6R,11R)-3,11-dimethyl-1,7-dioxaspiro[5.5]undec-2-yl]-1-hydroxybutyl}-8'-hydroxy-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]-1-methylprop-2-en-1-yl}-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid, MANGANESE (II) ION, SULFATE ION, ... 著者 Jeffrey, P.D, Huhn, J, Shi, Y. 登録日 2009-10-13 公開日 2009-11-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 A structural basis for the reduced toxicity of dinophysistoxin-2. Chem.Res.Toxicol., 22, 2009
3KVF	Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 分子名称: METHYL 4-AMINOBUTANOATE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L1 著者 Davies, C.W, Maiti, T.K, Das, C. 登録日 2009-11-30 公開日 2010-06-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107, 2010
3KVQ	Crystal structure of VEGFR2 extracellular domain D7 分子名称: Vascular endothelial growth factor receptor 2 著者 Yang, Y, Opatowsky, Y, Xie, P, Schlessinger, J. 登録日 2009-11-30 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling Proc.Natl.Acad.Sci.USA, 107, 2010
3KW5	Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 分子名称: METHYL 4-AMINOBUTANOATE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L1 著者 Maiti, T.K, Boudreaux, D.A, Das, C. 登録日 2009-11-30 公開日 2010-06-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107, 2010
3KJY	Crystal structure of reduced HOMO SAPIENS CLIC3 分子名称: Chloride intracellular channel protein 3, SULFATE ION 著者 Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. 登録日 2009-11-04 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of human CLIC3 at 2 A resolution Proteins, 78, 2010

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