6CPJ
 
 | | Solution structure of SH3 domain from Shank2 | | 分子名称: | SH3 and multiple ankyrin repeat domains protein 2 | | 著者 | Ishida, H, Vogel, H.J. | | 登録日 | 2018-03-13 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels.
FEBS Lett., 592, 2018
|
|
6DNZ
 | | Trypanosoma brucei PRMT1 enzyme-prozyme heterotetrameric complex with AdoHcy | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Arginine N-methyltransferase, putative, ... | | 著者 | Hashimoto, H, Kafkova, L, Jordan, K, Read, L.K, Debler, E.W. | | 登録日 | 2018-06-08 | | 公開日 | 2019-06-12 | | 最終更新日 | 2020-02-12 | | 実験手法 | X-RAY DIFFRACTION (2.384 Å) | | 主引用文献 | Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme).
J.Mol.Biol., 432, 2020
|
|
5IC5
 | | Bacteriophytochrome response regulator RtBRR | | 分子名称: | CACODYLATE ION, Candidate response regulator, CheY, ... | | 著者 | Baker, A.W, Satyshur, K.A, Forest, K.T. | | 登録日 | 2016-02-22 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction.
J.Bacteriol., 198, 2016
|
|
5KLH
 | |
5KMX
 | |
5EKU
 | |
2YHU
 | | Trypanosoma brucei PTR1 in complex with inhibitor WHF30 | | 分子名称: | 3-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1-THIOPHEN-2-YLPROPAN-1-ONE, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P. | | 登録日 | 2011-05-06 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017
|
|
1APJ
 | | NMR STUDY OF THE TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-LIKE DOMAIN (TB MODULE/8-CYS DOMAIN), NMR, 21 STRUCTURES | | 分子名称: | FIBRILLIN | | 著者 | Yuan, X, Downing, A.K, Knott, V, Handford, P.A. | | 登録日 | 1997-07-22 | | 公開日 | 1998-01-28 | | 最終更新日 | 2021-11-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils.
EMBO J., 16, 1997
|
|
5AON
 | | Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei | | 分子名称: | PEROXIN 14, SULFATE ION | | 著者 | Obita, T, Sugawara, Y, Mizuguchi, M, Watanabe, Y, Kawaguchi, K, Imanaka, T. | | 登録日 | 2015-09-11 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.646 Å) | | 主引用文献 | Characterization of the Interaction between Trypanosoma Brucei Pex5P and its Receptor Pex14P.
FEBS Lett., 590, 2016
|
|
6RXC
 | | Leishmania major pteridine reductase 1 (LmPTR1) in complex with inhibitor 4 (NMT-C0026) | | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1, methyl 1-[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-(3-oxidanylpropyl)amino]phenyl]carbonylpiperidine-4-carboxylate | | 著者 | Di Pisa, F, Dello Iacono, L, Pozzi, C, Mangani, S. | | 登録日 | 2019-06-07 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
J.Med.Chem., 65, 2022
|
|
3E4O
 | | Crystal structure of succinate bound state DctB | | 分子名称: | C4-dicarboxylate transport sensor protein dctB, MAGNESIUM ION, SUCCINIC ACID | | 著者 | Zhou, Y.F, Nan, J, Nan, B.Y, Liang, Y.H, Panjikar, S, Su, X.D. | | 登録日 | 2008-08-12 | | 公開日 | 2008-10-21 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
J.Mol.Biol., 383, 2008
|
|
3E4Q
 | | Crystal structure of apo DctB | | 分子名称: | C4-dicarboxylate transport sensor protein dctB, CALCIUM ION | | 著者 | Zhou, Y.F, Nan, J, Nan, B.Y, Liang, Y.H, Panjikar, S, Su, X.D. | | 登録日 | 2008-08-12 | | 公開日 | 2008-10-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
J.Mol.Biol., 383, 2008
|
|
5H9K
 | |
3E4P
 | | Crystal structure of malonate occupied DctB | | 分子名称: | C4-dicarboxylate transport sensor protein dctB, MALONIC ACID, STRONTIUM ION | | 著者 | Zhou, Y.F, Nan, J, Nan, B.Y, Liang, Y.H, Panjikar, S, Su, X.D. | | 登録日 | 2008-08-12 | | 公開日 | 2008-10-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
J.Mol.Biol., 383, 2008
|
|
2YHI
 | | Trypanosoma brucei PTR1 in complex with inhibitor WH16 | | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | | 著者 | Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P. | | 登録日 | 2011-05-03 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017
|
|
2FYF
 | | Structure of a putative phosphoserine aminotransferase from Mycobacterium Tuberculosis | | 分子名称: | GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, ... | | 著者 | Coulibaly, F, Lassalle, E, Baker, E.N, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | | 登録日 | 2006-02-07 | | 公開日 | 2007-01-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.D, 68, 2012
|
|
6ITO
 | | Crystal structure of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, AMP and inhibitor Ribose 5-Phosphate | | 分子名称: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, OXALATE ION, ... | | 著者 | Zhong, W, Cai, Q, El Sahili, A, Mu, Y, Lescar, J, Dedon, P.C. | | 登録日 | 2018-11-24 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.
J.Mol.Biol., 431, 2019
|
|
2VZ0
 | | Pteridine Reductase 1 (PTR1) from Trypanosoma Brucei in complex with NADP and DDD00066641 | | 分子名称: | 6-(4-methylphenyl)quinazoline-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | | 著者 | Robinson, D.A, Thompson, S, Sienkiewicz, N, Fairlamb, A.H. | | 登録日 | 2008-07-29 | | 公開日 | 2009-09-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Development and Validation of a Cytochrome C Coupled Assay for Pteridine Reductase 1 and Dihydrofolate Reductase.
Anal.Biochem., 396, 2010
|
|
2WD8
 | | PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204 | | 分子名称: | 1-(3,4-DICHLOROBENZYL)-7-PHENYL-1H-BENZIMIDAZOL-2-AMINE, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R. | | 登録日 | 2009-03-20 | | 公開日 | 2009-06-30 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening.
J.Med.Chem., 52, 2009
|
|
2WD7
 | | PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00066750 | | 分子名称: | 6-chloro-1H-benzimidazol-2-amine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | | 著者 | Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R. | | 登録日 | 2009-03-20 | | 公開日 | 2009-06-30 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening.
J.Med.Chem., 52, 2009
|
|
3UAQ
 | | Crystal Structure of the N-lobe Domain of Lactoferrin Binding Protein B (LbpB) of Moraxella bovis | | 分子名称: | LbpB B-lobe | | 著者 | Arutyunova, E, Brooks, C.L, Beddeck, A, Mak, M.W, Schryvers, A.B, Lemieux, M.J. | | 登録日 | 2011-10-21 | | 公開日 | 2012-03-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.9318 Å) | | 主引用文献 | Crystal structure of the N-lobe of lactoferrin binding protein B from Moraxella bovis(1).
Biochem.Cell Biol., 90, 2012
|
|
1Y98
 | | Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide. | | 分子名称: | Breast cancer type 1 susceptibility protein, COBALT (II) ION, CtIP PHOSPHORYLATED PEPTIDE, ... | | 著者 | Varma, A.K, Brown, R.S, Birrane, G, Ladias, J.A.A. | | 登録日 | 2004-12-14 | | 公開日 | 2005-08-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.
Biochemistry, 44, 2005
|
|
1MM3
 | | Solution structure of the 2nd PHD domain from Mi2b with C-terminal loop replaced by corresponding loop from WSTF | | 分子名称: | Mi2-beta(Chromodomain helicase-DNA-binding protein 4) and transcription factor WSTF, ZINC ION | | 著者 | Kwan, A.H.Y, Gell, D.A, Verger, A, Crossley, M, Matthews, J.M, Mackay, J.P. | | 登録日 | 2002-09-02 | | 公開日 | 2003-07-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Engineering a Protein Scaffold from a PHD Finger
structure, 11, 2003
|
|
1MM2
 | | Solution structure of the 2nd PHD domain from Mi2b | | 分子名称: | Mi2-beta, ZINC ION | | 著者 | Kwan, A.H.Y, Gell, D.A, Verger, A, Crossley, M, Matthews, J.M, Mackay, J.P. | | 登録日 | 2002-09-02 | | 公開日 | 2003-07-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Engineering a Protein Scaffold from a PHD Finger
structure, 11, 2003
|
|
8ATJ
 | | Crystal Structure of Shank2-SAM domain | | 分子名称: | CHLORIDE ION, FORMIC ACID, Isoform 4 of SH3 and multiple ankyrin repeat domains protein 2, ... | | 著者 | Bento, I, Gracia Alai, M, Kreienkamp, J.-H. | | 登録日 | 2022-08-23 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.117 Å) | | 主引用文献 | Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans.
Mol Psychiatry, 2022
|
|
