2JF1
 
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3B3A
 | | Structure of E163K/R145E DJ-1 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Protein DJ-1 | | 著者 | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | | 登録日 | 2007-10-19 | | 公開日 | 2008-01-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
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3B5G
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2JTZ
 | | Solution structure and chemical shift assignments of the F104-to-5-flurotryptophan mutant of cardiac troponin C | | 分子名称: | Troponin C, slow skeletal and cardiac muscles | | 著者 | Wang, X, Mercier, P, Letourneau, P, Sykes, B.D. | | 登録日 | 2007-08-10 | | 公開日 | 2007-08-28 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Effects of Phe-to-Trp mutation and fluorotryptophan incorporation on the solution structure of cardiac troponin C, and analysis of its suitability as a potential probe for in situ NMR studies
Protein Sci., 14, 2005
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3FP8
 | | Anionic trypsin variant S195A in complex with bovine pancreatic trypsin inhibitor (BPTI) determined to the 1.46 A resolution limit | | 分子名称: | 1,2-ETHANEDIOL, Anionic trypsin-2, CALCIUM ION, ... | | 著者 | Zakharova, E, Horvath, M.P, Goldenberg, D.P, Curtice, K. | | 登録日 | 2009-01-04 | | 公開日 | 2009-02-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Structure of a serine protease poised to resynthesize a peptide bond.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3F6B
 | | Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor PAA | | 分子名称: | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-2-[(1S,2E)-1-hydroxy-3-pyridin-3-ylprop-2-en-1-yl]-4-methyl-1,3-thiazol-3-ium, Benzoylformate decarboxylase, MAGNESIUM ION | | 著者 | Brandt, G.S, McLeish, M.J, Kenyon, G.L, Petsko, G.A, Ringe, D, Jordan, F. | | 登録日 | 2008-11-05 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.
Biochemistry, 48, 2009
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3C2M
 | | Ternary complex of DNA POLYMERASE BETA with a G:dAPCPP mismatch in the active site | | 分子名称: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DGP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), ... | | 著者 | Batra, V.K, Beard, W.A, Shock, D.D, Pedersen, L.C, Wilson, S.H. | | 登録日 | 2008-01-25 | | 公開日 | 2008-05-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.
Mol.Cell, 30, 2008
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3F9Q
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3GT3
 | | Structure of proteinase K with the mad triangle B3C | | 分子名称: | 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid, Proteinase K, SULFATE ION | | 著者 | Beck, T, Gruene, T, Sheldrick, G.M. | | 登録日 | 2009-03-27 | | 公開日 | 2009-04-14 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The magic triangle goes MAD: experimental phasing with a bromine derivative
Acta Crystallogr.,Sect.D, 66, 2010
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3BM4
 | | Crystal Structure of Human ADP-ribose Pyrophosphatase NUDT5 In complex with magnesium and AMPcpr | | 分子名称: | ADP-sugar pyrophosphatase, ALPHA-BETA METHYLENE ADP-RIBOSE, MAGNESIUM ION | | 著者 | Zha, M, Guo, Q, Zhang, Y, Zhong, C, Ou, Y, Ding, J. | | 登録日 | 2007-12-12 | | 公開日 | 2008-05-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular Mechanism of ADP-Ribose Hydrolysis By Human NUDT5 From Structural and Kinetic Studies
J.Mol.Biol., 379, 2008
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2K2O
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3GY8
 | | A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC | | 分子名称: | 1,2-ETHANEDIOL, BERENIL, CALCIUM ION, ... | | 著者 | Perilo, C.S, Pereira, M.T, Santoro, M.M, Nagem, R.A.P. | | 登録日 | 2009-04-03 | | 公開日 | 2010-03-23 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model.
Int.J.Biol.Macromol., 46, 2010
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2W0P
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2VSL
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2VOD
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU | | 分子名称: | 5'-R(*AP*UP*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN | | 著者 | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | 登録日 | 2008-02-15 | | 公開日 | 2008-05-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2JDF
 | | Human gamma-B crystallin | | 分子名称: | GAMMA CRYSTALLIN B | | 著者 | Ebersbach, H, Fiedler, E, Scheuermann, T, Fiedler, M, Stubbs, M.T, Reimann, C, Proetzel, G, Rudolph, R, Fiedler, U. | | 登録日 | 2007-01-08 | | 公開日 | 2007-07-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Affilin-Novel Binding Molecules Based on Human Gamma-B-Crystallin, an All Beta-Sheet Protein.
J.Mol.Biol., 372, 2007
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2WGH
 | | Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg. | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Welin, R.M, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kragh-Nielsen, T, Kotzsch, A, Kotenyova, T, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Wisniewska, M, Nordlund, P. | | 登録日 | 2009-04-19 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for Allosteric Regulation of Human Ribonucleotide Reductase by Nucleotide-Induced Oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
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2W18
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2JXL
 | | Solution structure of cardiac N-domain troponin C mutant F77W-V82A | | 分子名称: | CALCIUM ION, Troponin C, slow skeletal and cardiac muscles | | 著者 | Julien, O, Sun, Y, Wang, X, Lindhout, D.A, Thiessen, A, Irving, M, Sykes, B.D. | | 登録日 | 2007-11-20 | | 公開日 | 2007-12-04 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Tryptophan Mutants of Cardiac Troponin C: 3D Structure, Troponin I Affinity, and in Situ Activity.
Biochemistry, 47, 2008
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3BUY
 | | MHC-I in complex with peptide | | 分子名称: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... | | 著者 | Rossjohn, J, La Gruta, N.L, Purcell, A.W, Turner, S.J, Dunstone, M.A. | | 登録日 | 2008-01-03 | | 公開日 | 2008-03-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2K1A
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3BV7
 | | Crystal structure of Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and glycerol. Resolution: 1.79 A. | | 分子名称: | 3-oxo-5-beta-steroid 4-dehydrogenase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Di Costanzo, L, Drury, J, Penning, T.M, Christianson, D.W. | | 登録日 | 2008-01-04 | | 公開日 | 2008-04-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis.
J.Biol.Chem., 283, 2008
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3BL1
 | | Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications | | 分子名称: | 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, Carbonic anhydrase 2, MERCURY (II) ION, ... | | 著者 | Temperini, C, Cecchi, A, Supuran, C.T. | | 登録日 | 2007-12-10 | | 公開日 | 2008-07-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Bioorg.Med.Chem.Lett., 18, 2008
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3C5N
 | | Structure of human TULP1 in complex with IP3 | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Tubby-related protein 1 | | 著者 | Busam, R.D, Lehtio, L, Arrowsmith, C.H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Herman, M.D, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Weigelt, J, Welin, M, Berglund, H, Structural Genomics Consortium (SGC) | | 登録日 | 2008-01-31 | | 公開日 | 2008-04-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of human TULP1 in complex with IP3
To be published
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3H89
 | | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 4) | | 分子名称: | Cathepsin L1, N~2~,N~6~-bis(biphenyl-4-ylacetyl)-L-lysyl-D-arginyl-N-(2-phenylethyl)-L-tyrosinamide | | 著者 | Tulsidas, S.R, Chowdhury, S.F, Kumar, S, Joseph, L, Purisima, E.O, Sivaraman, J. | | 登録日 | 2009-04-29 | | 公開日 | 2009-10-20 | | 最終更新日 | 2014-02-05 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J.Med.Chem., 52, 2009
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