9G7G
 
 | | Structure of the clippase PaJOS from Pigmentiphaga aceris | | 分子名称: | PaJOS, Polyubiquitin-B, prop-2-en-1-amine | | 著者 | Baumann, U, Uthoff, M, Hermanns, T, Hofmann, K. | | 登録日 | 2024-07-21 | | 公開日 | 2025-04-23 | | 最終更新日 | 2025-05-21 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode.
Mol.Cell, 85, 2025
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7RSM
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9GF7
 | | SARS-CoV2 Main Protease (Mpro) in complex with the covalent inhibitor 28a | | 分子名称: | 3C-like proteinase nsp5, ~{N}-[(2~{S})-4-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]quinoline-8-carboxamide | | 著者 | Lolicato, M, Arrigoni, C. | | 登録日 | 2024-08-08 | | 公開日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Synthesis and biological investigation of peptidomimetic SARS-CoV-2 main protease inhibitors bearing quinoline-based heterocycles at P 3.
Arch Pharm, 358, 2025
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7RVS
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI19 | | 分子名称: | 3C-like proteinase, N-[(benzyloxy)carbonyl]-3-methyl-L-valyl-3-cyclopropyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-alaninamide | | 著者 | Yang, K, Liu, W. | | 登録日 | 2021-08-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Eur.J.Med.Chem., 240, 2022
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1LZ8
 | | LYSOZYME PHASED ON ANOMALOUS SIGNAL OF SULFURS AND CHLORINES | | 分子名称: | CHLORIDE ION, PROTEIN (LYSOZYME), SODIUM ION | | 著者 | Dauter, Z, Dauter, M, De La Fortelle, E, Bricogne, G, Sheldrick, G.M. | | 登録日 | 1999-03-14 | | 公開日 | 1999-05-26 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Can anomalous signal of sulfur become a tool for solving protein crystal structures?
J.Mol.Biol., 289, 1999
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2OWI
 | | Solution structure of the RGS domain from human RGS18 | | 分子名称: | Regulator of G-protein signaling 18 | | 著者 | Higman, V.A, Leidert, M, Bray, J, Elkins, J, Soundararajan, M, Doyle, D.A, Gileadi, C, Phillips, C, Schoch, G, Yang, X, Brockmann, C, Schmieder, P, Diehl, A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Oschkinat, H, Ball, L.J, Structural Genomics Consortium (SGC) | | 登録日 | 2007-02-16 | | 公開日 | 2007-02-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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9G5C
 | | Assembly intermediate of human mitochondrial ribosome small subunit (State B) | | 分子名称: | 12S mitochondrial rRNA, 12S rRNA N4-methylcytidine (m4C) methyltransferase, 28S ribosomal protein S10, ... | | 著者 | Finke, A.F, Heinrichs, M, Aibara, S, Richter-Dennerlein, R, Hillen, H.S. | | 登録日 | 2024-07-16 | | 公開日 | 2025-04-23 | | 最終更新日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Coupling of ribosome biogenesis and translation initiation in human mitochondria.
Nat Commun, 16, 2025
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9G5B
 | | Assembly intermediate of human mitochondrial ribosome small subunit (State A) | | 分子名称: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | 著者 | Finke, A.F, Heinrichs, M, Aibara, S, Richter-Dennerlein, R, Hillen, H.S. | | 登録日 | 2024-07-16 | | 公開日 | 2025-04-23 | | 最終更新日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Coupling of ribosome biogenesis and translation initiation in human mitochondria.
Nat Commun, 16, 2025
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1M0I
 | | Crystal Structure of Bacteriophage T7 Endonuclease I with a Wild-Type Active Site | | 分子名称: | SULFATE ION, endodeoxyribonuclease I | | 著者 | Hadden, J.M, Declais, A.C, Phillips, S.E, Lilley, D.M. | | 登録日 | 2002-06-13 | | 公開日 | 2002-12-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Metal ions bound at the active site of the junction-resolving enzyme T7 endonuclease I
Embo J., 21, 2002
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7RVO
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9GLR
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1M1C
 | | Structure of the L-A virus | | 分子名称: | Major coat protein | | 著者 | Naitow, H, Tang, J, Canady, M, Wickner, R.B, Johnson, J.E. | | 登録日 | 2002-06-18 | | 公開日 | 2002-10-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism.
Nat.Struct.Biol., 9, 2002
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7RVR
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI18 | | 分子名称: | 3C-like proteinase, N-[(benzyloxy)carbonyl]-3-methyl-L-valyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-methyl-L-leucinamide | | 著者 | Yang, K, Liu, W. | | 登録日 | 2021-08-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Eur.J.Med.Chem., 240, 2022
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7RW0
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI27 | | 分子名称: | 3C-like proteinase, N-{[(3-chlorophenyl)methoxy]carbonyl}-L-valyl-3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-alaninamide | | 著者 | Yang, K, Liu, W. | | 登録日 | 2021-08-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Eur.J.Med.Chem., 240, 2022
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1MDL
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9GF8
 | | Human Monocarboxylate Transporter 8 | | 分子名称: | ALFA-tag binding nanobody, Monocarboxylate transporter 8 | | 著者 | Coscia, F, Tassinari, M. | | 登録日 | 2024-08-08 | | 公開日 | 2025-05-21 | | 最終更新日 | 2025-06-11 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Molecular mechanism of thyroxine transport by monocarboxylate transporters.
Nat Commun, 16, 2025
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7RVM
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI11 | | 分子名称: | 3C-like proteinase, N-[(benzyloxy)carbonyl]-L-valyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-methyl-L-leucinamide | | 著者 | Yang, K, Liu, W. | | 登録日 | 2021-08-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Eur.J.Med.Chem., 240, 2022
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9GS3
 | | Cryo-EM structure of human SLC35B1-E33A variant with ADP in inward facing conformation | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Maltodextrin-binding protein, SLC35B1-E33A inward facing conformation | | 著者 | Gulati, A, Ahn, D, Suades, A, Drew, D. | | 登録日 | 2024-09-13 | | 公開日 | 2025-05-21 | | 最終更新日 | 2025-08-20 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1.
Nature, 643, 2025
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7RVW
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI23 | | 分子名称: | 3C-like proteinase, benzyl (1-{[(2S)-3-cyclohexyl-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-1-oxopropan-2-yl]carbamoyl}cyclopropyl)carbamate | | 著者 | Yang, K, Liu, W. | | 登録日 | 2021-08-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Eur.J.Med.Chem., 240, 2022
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1M30
 | | Solution structure of N-terminal SH3 domain from oncogene protein c-Crk | | 分子名称: | Proto-oncogene C-crk | | 著者 | Schumann, F.H, Varadan, R, Tayakuniyil, P.P, Hall, J.B, Camarero, J.A, Fushman, D. | | 登録日 | 2002-06-26 | | 公開日 | 2003-08-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Changing protein backbone topology: Structural and dynamic consequences of the backbone cyclization in SH3 domain
To be Published
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1M3C
 | | Solution structure of a circular form of the N-terminal SH3 domain (E132C, E133G, R191G mutant) from oncogene protein c-Crk | | 分子名称: | Proto-oncogene C-crk | | 著者 | Schumann, F.H, Varadan, R, Tayakuniyil, P.P, Hall, J.B, Camarero, J.A, Fushman, D. | | 登録日 | 2002-06-27 | | 公開日 | 2003-08-05 | | 最終更新日 | 2024-11-06 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Changing protein backbone topology: Structural and dynamic consequences of the backbone cyclization in SH3 domain
To be Published
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2OUL
 | | The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family | | 分子名称: | Chagasin, Falcipain 2 | | 著者 | Wang, S.X, Chand, K, Huang, R, Whisstock, J, Jacobelli, J, Fletterick, R.J, Rosenthal, P.J, McKerrow, J.H. | | 登録日 | 2007-02-11 | | 公開日 | 2008-02-26 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure, 15, 2007
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9GRY
 | | Cryo-EM structure of human SLC35B1-Q113F variant with AMP-PNP | | 分子名称: | Maltodextrin-binding protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, human SLC35B1-Q113F | | 著者 | Gulati, A, Ahn, D, Suades, A, Drew, D. | | 登録日 | 2024-09-13 | | 公開日 | 2025-05-21 | | 最終更新日 | 2025-08-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1.
Nature, 643, 2025
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1M3U
 | | Crystal Structure of Ketopantoate Hydroxymethyltransferase complexed the Product Ketopantoate | | 分子名称: | 3-methyl-2-oxobutanoate hydroxymethyltransferase, KETOPANTOATE, MAGNESIUM ION | | 著者 | von Delft, F, Inoue, T, Saldanha, S.A, Ottenhof, H.H, Dhanaraj, V, Witty, M, Abell, C, Smith, A.G, Blundell, T.L. | | 登録日 | 2002-06-30 | | 公開日 | 2003-07-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of E. coli Ketopantoate Hydroxymethyl Transferase Complexed with Ketopantoate and Mg(2+), Solved by Locating 160 Selenomethionine Sites.
Structure, 11, 2003
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7RFQ
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