PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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7B3X	Notum complex with ARUK3003748 分子名称: 6-(m-tolylthio)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Fish, P, Jones, E.Y. 登録日 2020-12-01 公開日 2021-12-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
7B3G	Notum complex with ARUK3003902 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-((2-chlorophenyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, ... 著者 Zhao, Y, Jone, E.Y. 登録日 2020-11-30 公開日 2021-12-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
7B45	Notum complex with ARUK3003934 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(3-methylsulfanylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one, ... 著者 Fish, P, Jones, E.Y. 登録日 2020-12-02 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
7B50	Notum complex with ARUK3003778 分子名称: 3-(3,4-dichlorophenyl)sulfanyl-1$l^{4},2,7,8-tetrazabicyclo[4.3.0]nona-1(6),2,4,7-tetraen-9-one, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Jones, E.Y, Fish, P. 登録日 2020-12-03 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
7PKV	Notum_Inhibitor ARUK3000223 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Ruza, R, Zhao, Y, Fish, P, Jones, E.Y. 登録日 2021-08-26 公開日 2022-09-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J.Med.Chem., 65, 2022
6XSW	Structure of the Notch3 NRR in complex with an antibody Fab Fragment 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-N3 Fab Heavy Chain, ... 著者 Bard, J. 登録日 2020-07-16 公開日 2021-07-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med, 2, 2021
5UK5	Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Garcia, K.C, Luca, V.C. 登録日 2017-01-19 公開日 2017-03-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.506 Å) 主引用文献 Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science, 355, 2017
6M7G	Crystal structure of ArsN, N-acetyltransferase with substrate phosphinothricin from Pseudomonas putida KT2440 分子名称: PHOSPHINOTHRICIN, Phosphinothricin N-acetyltransferase 著者 Venkadesh, S, Dheeman, D.S, Yoshinaga, M, Kandavelu, P, Rosen, B.P. 登録日 2018-08-20 公開日 2019-04-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.657 Å) 主引用文献 Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic. Commun Biol, 2, 2019
2F8Y	Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution. 分子名称: Notch homolog 1, translocation-associated (Drosophila), SULFATE ION 著者 Nam, Y, Sliz, P, Blacklow, S.C. 登録日 2005-12-04 公開日 2006-04-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell(Cambridge,Mass.), 124, 2006
7B84	Notum-Fragment065 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2020-12-12 公開日 2022-01-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
7B87	Notum-Fragment074 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2020-12-12 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
7B86	Notum-Fragment067 分子名称: 1,2-ETHANEDIOL, 2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2020-12-12 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
7B89	Notum-Fragment077 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2020-12-12 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
7BLT	Notum_Maybridge_4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(4-~{tert}-butylphenyl)-1,2,4-oxadiazole-5-carbohydrazide, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Zhao, Y, Jones, E.Y. 登録日 2021-01-19 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Notum Inhibitor To Be Published
7BLS	Notum-maybridge_18 分子名称: 2-[(3-Nitro-2-pyridyl)thio]acetic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2021-01-18 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Notum Fragment Screen To Be Published
7BLU	Notum_Maybridge_56 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5-bis(chloranyl)-3-nitro-1~{H}-pyridazin-6-one, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jones, E.Y. 登録日 2021-01-19 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 Notum Inhibitor To Be Published
7B7Y	Notum-Fragment064 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(4-methyl-1,3-thiazol-2-yl)propanamide, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2020-12-11 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Notum Fragment Screen To Be Published
7B7X	Notum-Fragment063 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(2,1,3-benzoxadiazol-4-yl)acetamide, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2020-12-11 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Notum Fragment Screen To Be Published
7B7W	Notum-Fragment049 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea, ... 著者 Zhao, Y, Jonees, E.Y. 登録日 2020-12-11 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Notum Fragment Screen To Be Published
5FU6	NOT module of the human CCR4-NOT complex (Crystallization mutant) 分子名称: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 著者 Raisch, T, Bhandari, D, Sabath, K, Helms, S, Valkov, E, Weichenrieder, O, Izaurralde, E. 登録日 2016-01-21 公開日 2016-03-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos Embo J., 35, 2016
6HON	Drosophila NOT4 CBM peptide bound to human CAF40 分子名称: CCR4-NOT transcription complex subunit 4, isoform L, CCR4-NOT transcription complex subunit 9, ... 著者 Raisch, T, Izaurralde, E, Weichenrieder, O. 登録日 2018-09-17 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex. Genes Dev., 33, 2019
8FY3	Structure of NOT1:NOT10:NOT11 module of the human CCR4-NOT complex 分子名称: CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 10, CCR4-NOT transcription complex subunit 11 著者 Lea, S.M, Deme, J.C, Raisch, T, Pekovic, F, Valkov, E. 登録日 2023-01-25 公開日 2023-07-26 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Structure and assembly of the NOT10:11 module of the CCR4-NOT complex. Commun Biol, 6, 2023
4C0F	Structure of the NOT-box domain of human CNOT2 分子名称: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2 著者 Boland, A, Chen, Y, Raisch, T, Jonas, S, Izaurralde, E, Weichenrieder, O. 登録日 2013-08-01 公開日 2013-10-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and Assembly of the not Module of the Human Ccr4-not Complex Nat.Struct.Mol.Biol., 20, 2013
4CT6	CNOT9-CNOT1 complex 分子名称: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CELL DIFFERENTIATION PROTEIN RCD1 HOMOLOG 著者 Basquin, J, Ozgur, S, Conti, E. 登録日 2014-03-12 公開日 2014-05-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Structural and Biochemical Insights to the Role of the Ccr4-not Complex and Ddx6 ATPase in Microrna Repression. Mol.Cell, 54, 2014
4CT4	CNOT1 MIF4G domain - DDX6 complex 分子名称: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CHLORIDE ION, MAGNESIUM ION, ... 著者 Ozgur, S, Basquin, J, Conti, E. 登録日 2014-03-12 公開日 2014-05-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Biochemical Insights to the Role of the Ccr4- not Complex and Ddx6 ATPase in Microrna Repression. Mol.Cell, 54, 2014

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