PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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7WZW	Cryo-EM structure of MEC1-DDC2-MMS 分子名称: DNA damage checkpoint protein LCD1, Serine/threonine-protein kinase MEC1 著者 Zhang, Q, Zhang, Q. 登録日 2022-02-19 公開日 2023-03-01 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins. Cell Discov, 8, 2022
7WZR	Cryo-EM structure of Mec1-HU 分子名称: DNA damage checkpoint protein LCD1, Serine/threonine-protein kinase MEC1 著者 Zhang, Q, Zhang, Q. 登録日 2022-02-19 公開日 2023-03-08 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins. Cell Discov, 8, 2022
5MFQ	Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, ... 著者 Larsen, A.P, Frydenvang, K, Kastrup, J.S. 登録日 2016-11-18 公開日 2017-04-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
4XXD	Crystal Structure of mid-region amyloid beta capture by solanezumab 分子名称: Amyloid-beta fragment, Fab Heavy Chain, Fab Light Chain 著者 Hermans, S.J, Crespi, G.A.N, Parker, M.W, Miles, L.A. 登録日 2015-01-30 公開日 2015-04-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies. Sci Rep, 5, 2015
7XD6	The Tet-S2 state with a pseudoknotted 4-way junction of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon 分子名称: MAGNESIUM ION, SPERMIDINE, The Tet-S2 state with a pseudoknotted 4-way junction molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (5'-exon), ... 著者 Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. 登録日 2022-03-26 公開日 2023-04-05 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
5C46	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex with GTP gamma S loaded Rab11 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Phosphatidylinositol 4-kinase beta, ... 著者 Burke, J.E, Fowler, M.L. 登録日 2015-06-17 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11. Protein Sci., 25, 2016
7RSE	NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... 著者 Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. 登録日 2021-08-11 公開日 2021-09-22 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. Chem Sci, 12, 2021
7RSC	NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... 著者 Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. 登録日 2021-08-11 公開日 2021-09-22 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. Chem Sci, 12, 2021
6HU4	F97L Hepatitis B core protein capsid 分子名称: Capsid protein 著者 Bottcher, B, Nassal, M. 登録日 2018-10-05 公開日 2018-12-26 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (2.64 Å) 主引用文献 Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype. J. Mol. Biol., 430, 2018
6BC1	A Complex between PH Domain of p190RhoGEF and Activated Rac1 Bound to a GTP Analog 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1, ... 著者 Chen, Z, Sternweis, P.C. 登録日 2017-10-20 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. J. Struct. Biol., 202, 2018
6EQM	Crystal Structure of Human BACE-1 in Complex with CNP520 分子名称: Beta-secretase 1, ~{N}-[6-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]-5-fluoranyl-pyridin-2-yl]-3-chloranyl-5-(trifluoromethyl)pyridine-2-carboxamide 著者 Rondeau, J.-M, Wirth, E. 登録日 2017-10-13 公開日 2018-09-19 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO Mol Med, 10, 2018
6R4O	Structure of a truncated adenylyl cyclase bound to MANT-GTP, forskolin and an activated stimulatory Galphas protein 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, ... 著者 Qi, C, Sorrentino, S, Medalia, O, Korkhov, V.M. 登録日 2019-03-22 公開日 2019-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science, 364, 2019
5CM0	Crystal structure of branched-chain aminotransferase from thermophilic archaea Geoglobus acetivorans 分子名称: Branched-chain transaminase, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE 著者 Boyko, K.M, Nikolaeva, A.Y, Stekhanova, T.N, Mardanov, A.V, Rakitin, A.L, Ravin, N.V, Popov, V.O. 登録日 2015-07-16 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus : Biochemical and Structural Characterization. Front Bioeng Biotechnol, 7, 2019
6BCA	A Complex between PH Domain of LbcRhoGEF (AKAP-Lbc) and Activated RhoA Bound to a GTP Analog 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, A-kinase anchor protein 13, MAGNESIUM ION, ... 著者 Sternweis, P.C, Chen, Z. 登録日 2017-10-20 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.995 Å) 主引用文献 Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase. Data Brief, 17, 2018
7R04	Neurofibromin in open conformation 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform I of Neurofibromin 著者 Chaker-Margot, M, Scheffzek, K, Maier, T. 登録日 2022-02-01 公開日 2022-03-30 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of activation of the tumor suppressor protein neurofibromin. Mol.Cell, 82, 2022
6UYD	Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... 著者 Tzarum, N, Wilson, I.A, Zhu, J. 登録日 2019-11-13 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
6HU7	phosphorylated F97L Hepatitis B core protein capsid 分子名称: Capsid protein 著者 Bottcher, B, Nassal, M. 登録日 2018-10-05 公開日 2018-12-26 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype. J. Mol. Biol., 430, 2018
5MLA	Crystal structure of human RAS in complex with darpin K55 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION, ... 著者 Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. 登録日 2016-12-06 公開日 2017-12-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Inhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS To Be Published
5MFV	Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-521 at 2.18 A resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... 著者 Larsen, A.P, Frydenvang, K, Kastrup, J.S. 登録日 2016-11-18 公開日 2017-04-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.181 Å) 主引用文献 Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
6HTX	WT Hepatitis B core protein capsid 分子名称: Capsid protein 著者 Bottcher, B, Nassal, M. 登録日 2018-10-05 公開日 2018-12-26 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (2.66 Å) 主引用文献 Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype. J. Mol. Biol., 430, 2018
6EVY	Cryo-EM structure of GTPgammaS-microtubule co-polymerised with doublecortin 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Manka, S.W. 登録日 2017-11-03 公開日 2018-07-04 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability. Nat. Struct. Mol. Biol., 25, 2018
6R4P	Structure of a soluble domain of adenylyl cyclase bound to an activated stimulatory G protein 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Korkhov, V.M, Qi, C. 登録日 2019-03-22 公開日 2019-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science, 364, 2019
4TMZ	Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTPgammaS and potassium 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHLORIDE ION, GLYCEROL, ... 著者 Kuhle, B, Ficner, R. 登録日 2014-06-02 公開日 2014-09-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 A monovalent cation acts as structural and catalytic cofactor in translational GTPases. Embo J., 33, 2014
6FDW	Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-356 分子名称: (4aS,8aR)-2-(1-{2-aminothieno[2,3-d]pyrimidin-4-yl}piperidin-4-yl)-4-(3,4- dimethoxyphenyl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one, GLYCEROL, GUANIDINE, ... 著者 Singh, A.K, Brown, D.G. 登録日 2017-12-27 公開日 2019-04-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 TbrPDEB1 structure with inhibitor NPD-356 To be published
6R3Q	The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Korkhov, V.M, Qi, C. 登録日 2019-03-20 公開日 2019-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science, 364, 2019

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