PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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3MT9	Glycogen phosphorylase complexed with 4-nitrobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(4-nitrophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-30 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
3MQF	Glycogen phosphorylase complexed with 4-fluorobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(4-fluorophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-28 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
3MRT	Glycogen phosphorylase complexed with 4-pyridinecarboxaldehyde-4-(beta-D-glucopyranosyl) thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-{[(2E)-2-(pyridin-4-ylmethylidene)hydrazino]carbonothioyl}-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-29 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
3MSC	Glycogen phosphorylase complexed with 2-nitrobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2Z)-2-[(2-nitrophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-29 公開日 2011-03-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 The binding of beta-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors. Bioorg.Med.Chem., 18, 2010
5CR5	X-RAY CRYSTAL STRUCTURE AT 1.61A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A BIPHENYL PYRROLIDINE ETHER COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR. 分子名称: 1,2-ETHANEDIOL, 3-({(3R)-1-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}oxy)-N-methyl-2'-[(methylsulfonyl)amino]biphenyl-4-carboxamide, Branched-chain-amino-acid aminotransferase, ... 著者 Somers, D.O. 登録日 2015-07-22 公開日 2015-08-12 最終更新日 2015-09-02 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library. Acs Med.Chem.Lett., 6, 2015
5JLX	AntpHD with 15bp DNA duplex S-monothioated at Cytidine-8 分子名称: DNA (5'-D(*AP*GP*AP*AP*AP*GP*CP*(C7S)P*AP*TP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3'), Homeotic protein antennapedia, ... 著者 White, M.A, Zandarashvili, L, Iwahara, J, Nguyen, D. 登録日 2016-04-27 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.748 Å) 主引用文献 Stereospecific Effects of Oxygen-to-Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein-DNA Affinity. Chembiochem, 17, 2016
4WYD	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase from Mycobacterium tuberculosis complexed with a fragment from DSF screening 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... 著者 Dai, R, Finzel, B.C, Geders, T.W. 登録日 2014-11-17 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
8BLJ	Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1), apo state 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Heroven, C, Malinauskas, T, Aricescu, A.R. 登録日 2022-11-09 公開日 2023-11-22 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 GluD1 binds GABA and controls inhibitory plasticity. Science, 382, 2023
5IRR	Crystal structure of Septin GTPase domain from Chlamydomonas reinhardtii 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Septin-like protein 著者 Pinto, A.P.A, Pereira, H.M, Navarro, M.V.A.S, Brandao-Neto, J, Garratt, R.C, Araujo, A.P.U. 登録日 2016-03-14 公開日 2017-04-26 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Filaments and fingers: Novel structural aspects of the single septin from Chlamydomonas reinhardtii. J. Biol. Chem., 292, 2017
3QBH	Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors 分子名称: (4S)-4-(2-hydroxy-5-{[(3S,4S,5R)-4-hydroxy-1,1-dioxido-5-{[3-(propan-2-yl)benzyl]amino}tetrahydro-2H-thiopyran-3-yl]methyl}benzyl)-3-propyl-1,3-oxazolidin-2-one, Beta-secretase 1 著者 Rondeau, J.M. 登録日 2011-01-13 公開日 2011-03-23 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
7TYL	Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif 分子名称: Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-13 公開日 2022-03-23 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TZF	Human Amylin3 Receptor in complex with Gs and rat amylin peptide 分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-15 公開日 2022-03-23 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYH	Human Amylin2 Receptor in complex with Gs and human calcitonin peptide 分子名称: Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-13 公開日 2022-03-23 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYO	Calcitonin receptor in complex with Gs and human calcitonin peptide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-14 公開日 2022-03-23 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYN	Calcitonin Receptor in complex with Gs and salmon calcitonin peptide 分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-13 公開日 2022-03-30 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYY	Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-14 公開日 2022-03-23 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYF	Human Amylin1 Receptor in complex with Gs and rat amylin peptide 分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-13 公開日 2022-03-23 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.2 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYW	Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-14 公開日 2022-03-23 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYX	Human Amylin2 Receptor in complex with Gs and rat amylin peptide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-14 公開日 2022-03-30 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (2.55 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
7TYI	Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. 登録日 2022-02-13 公開日 2022-03-30 最終更新日 2022-04-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A structural basis for amylin receptor phenotype. Science, 375, 2022
3MS7	Glycogen phosphorylase complexed with 2-chlorobenzaldehyde-4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl) thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(2-chlorophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-29 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
8R4D	Focused map on the Roc-COR domains of the Roco protein from C. tepidum in the GTP state bound to the activating Nanobody NbRoco1 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, NbRoco1, Rab family protein 著者 Galicia, C, Versees, W. 登録日 2023-11-13 公開日 2024-05-01 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies. Elife, 13, 2024
4F5L	A Theoretical Optimized Mutant for the Conversion of Substrate Specificity and Activity of Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P7. 分子名称: 1,2-ETHANEDIOL, Aspartate aminotransferase 著者 Addington, T.A, Fisher, A.J, Toney, M.D. 登録日 2012-05-13 公開日 2013-05-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Janus: an algorithm for ranking functional importance of residues from protein sequence alignments. To be Published
8TC9	Human asparaginyl-tRNA synthetase bound to OSM-S-106 分子名称: Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ... 著者 Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. 登録日 2023-06-30 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
3MTD	Glycogen phosphorylase complexed with 4-hydroxybenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2Z)-2-[(4-hydroxyphenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-30 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.096 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010

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