PDB: 245396 件ウェブページステータス検索Chemie searchBIRD

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9HY5	sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 9.0 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ... 著者 Raucci, L, Orlandini, M, Pozzi, C. 登録日 2025-01-09 公開日 2025-04-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and antigen-binding surface definition of an anti-CD93 monoclonal antibody for the treatment of degenerative vascular eye diseases. Int.J.Biol.Macromol., 309, 2025
5LPB	Crystal structure of the BRI1 kinase domain (865-1160) in complex with ADP from Arabidopsis thaliana 分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein BRASSINOSTEROID INSENSITIVE 1 著者 Bojar, D, Martinez, J, Hothorn, M. 登録日 2016-08-12 公開日 2016-08-31 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation. Plant J., 78, 2014
5Z0D	1.16 A-resolution crystal structure of the deoxy-form tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein 分子名称: COPPER (II) ION, MelC, NITRATE ION, ... 著者 Matoba, Y, Sugiyama, M. 登録日 2017-12-19 公開日 2018-12-26 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
6MM5	Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 peptide (2799-2810) 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 van Petegem, F, Haji-Ghassemi, O. 登録日 2018-09-29 公開日 2019-05-08 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 cAMP-dependent protein kinase A in complex with RyR2 peptide (2799-2810) Mol.Cell, 2019
5INL	Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with deoxyadenosine 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA (5'-D(P*AP*CP*GP*AP*AP*TP*TP*CP*G)-3'), ... 著者 Schellenberg, M.J, Vilas, C.K, Williams, R.S. 登録日 2016-03-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.551 Å) 主引用文献 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
5LQU	Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-[6-(ethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Catechol O-methyltransferase, ... 著者 Ehler, A, Lerner, C, Ellermann, M, Rudolph, M.G. 登録日 2016-08-17 公開日 2016-10-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-[6-(ethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide To be published
5IEI	X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11 分子名称: 1,2-ETHANEDIOL, Cation-independent mannose-6-phosphate receptor, GLYCEROL, ... 著者 Nicholls, R.D, Williams, C, Strickland, M, Frago, S, Hassan, A.B, Crump, M.P. 登録日 2016-02-25 公開日 2016-05-18 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113, 2016
5ITP	Structure of the periplasmic binding protein NocT from A.tumefaciens in complex with octopine 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Nopaline-binding periplasmic protein, ... 著者 Vigouroux, A, Morera, S. 登録日 2016-03-17 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fitness costs restrict niche expansion by generalist niche-constructing pathogens. ISME J, 11, 2017
5ZAN	Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor 分子名称: 7-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]quinazolin-4-amine, Aurora kinase A 著者 Cheng, B, Lu, G, Zhou, H. 登録日 2018-02-07 公開日 2019-02-13 最終更新日 2025-09-24 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment. J.Med.Chem., 68, 2025
5IMH	D31P mutant of C69-family cysteine dipeptidase from Lactobacillus farciminis 分子名称: 1,2-ETHANEDIOL, ACETATE ION, COBALT (II) ION, ... 著者 Kono, R, Watanabe, K. 登録日 2016-03-06 公開日 2017-03-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.471 Å) 主引用文献 A C69-family cysteine dipeptidase from Lactobacillus farciminis; substrate recognition mechanism and autoproteolytic mechanism in enzyme maturation To Be Published
172L	PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME 分子名称: BETA-MERCAPTOETHANOL, T4 LYSOZYME 著者 Weaver, L.H, Zhang, X.-J, Matthews, B.W. 登録日 1995-03-24 公開日 1995-07-10 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme. J.Mol.Biol., 250, 1995
5F1H	Crystal structure of the BRD9 bromodamian in complex with BI-9564. 分子名称: 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 9 著者 Bader, G, Martin, L.J, Steurer, S, Weiss-Puxbaum, A, Zoephel, A. 登録日 2015-11-30 公開日 2016-03-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J.Med.Chem., 59, 2016
6A8K	Crystal structure of Ice-binding Protein from a Sea-Ice Microalga 分子名称: GLYCEROL, Ice binding protein 1 著者 Kondo, H, Bayer-Giraldi, M. 登録日 2018-07-09 公開日 2018-11-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Multiple binding modes of a moderate ice-binding protein from a polar microalga Phys Chem Chem Phys, 20, 2018
6G8R	SP140 PHD-Bromodomain complex with scFv 分子名称: 1,2-ETHANEDIOL, Nuclear body protein SP140, ZINC ION, ... 著者 Fairhead, M, Graslund, S, Strain-Damerell, C, Picaud, S.S, Pike, A.C.W, Pinkas, D.M, Wigren, E, Preger, C, Persson Lotsholm, H, Ossipova, E, Filippakopoulos, P, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Structural Genomics Consortium (SGC) 登録日 2018-04-09 公開日 2018-04-18 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 SP140 PHD-Bromodomain complex with scFv To Be Published
7W58	Crystal structure of acyl-carrier protein synthase from Mycobacterium smegmatis 分子名称: 1,2-ETHANEDIOL, 4'-phosphopantetheinyl transferase, NICKEL (II) ION 著者 Yadav, S, Bhatia, I, Biswal, B.K. 登録日 2021-11-29 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Identification, structure determination and analysis of Mycobacterium smegmatis acyl-carrier protein synthase (AcpS) crystallized serendipitously. Acta Crystallogr.,Sect.F, 78, 2022
1NLC	HIV-1 DIS(Mal) duplex Zn-soaked 分子名称: HIV-1 DIS(MAL) genomic RNA, ZINC ION 著者 Ennifar, E, Walter, P, Dumas, P. 登録日 2003-01-07 公開日 2003-05-13 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A crystallographic study of the binding of 13 metal ions to two related RNA duplexes. Nucleic Acids Res., 31, 2003
6MSA	Novel, potent, selective and brain penetrant phosphodiesterase 10A inhibitors 分子名称: 7,8-dimethoxy-1-methyl-2H-pyrazolo[3,4-c]cinnoline, MAGNESIUM ION, ZINC ION, ... 著者 Jakob, C.G. 登録日 2018-10-16 公開日 2019-01-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors. Bioorg. Med. Chem. Lett., 29, 2019
6RWQ	Engineered beta-lactoglobulin: variant F105L in complex with myristic acid 分子名称: 1,2-ETHANEDIOL, Beta-lactoglobulin, MYRISTIC ACID 著者 Loch, J.I, Gotkowski, M, Lewinski, K. 登録日 2019-06-05 公開日 2019-06-19 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure-based design approach to rational site-directed mutagenesis of beta-lactoglobulin. J.Struct.Biol., 210, 2020
5ZIK	Crystal structure of Ketopantoate reductase from Pseudomonas aeruginosa 分子名称: GLYCEROL, Probable 2-dehydropantoate 2-reductase, SULFATE ION 著者 Khanppnavar, B, Datta, S. 登録日 2018-03-16 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Genome-wide survey and crystallographic analysis suggests a role for both horizontal gene transfer and duplication in pantothenate biosynthesis pathways. Biochim Biophys Acta Gen Subj, 1863, 2019
5FD5	manganese uptake regulator 分子名称: 1,2-ETHANEDIOL, Ferric uptake regulation protein, SULFATE ION 著者 Bellini, D, Lebedev, A, Keegan, R, Walsh, M.A. 登録日 2015-12-15 公開日 2016-12-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structure of an apo metal-free manganese uptake regulator, mur To Be Published
6CMJ	Human CAMKK2 with GSK650393 分子名称: 1,2-ETHANEDIOL, 2-(2-methylpropyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid, Calcium/calmodulin-dependent protein kinase kinase 2, ... 著者 Williams, S.P, Reid, R.A, Price, D.J, Drewry, D.H. 登録日 2018-03-05 公開日 2018-04-04 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorg. Med. Chem. Lett., 28, 2018
6CC7	Structure of Fungal GH62 from Thielavia terretris 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Glycoside hydrolase family 62 protein, ... 著者 Camargo, S, Mulinari, E.J, Almeida, L.R, Muniz, J.R.C. 登録日 2018-02-06 公開日 2019-02-13 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structure of Fungal GH62 from Thielavia terretris To Be Published
6N3N	Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents 分子名称: N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide, eIF-2-alpha kinase GCN2,eIF-2-alpha kinase GCN2 著者 Hoffman, I.D, Fujimoto, J, Kurasawa, O, Takagi, T, Klein, M.G, Kefala, G, Ding, S.C, Cary, D.R, Mizojiri, R. 登録日 2018-11-15 公開日 2019-10-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. Acs Med.Chem.Lett., 10, 2019
7L7A	Solution Structure of NuxVA 分子名称: NuxVA 著者 Mari, F, Dovell, S. 登録日 2020-12-28 公開日 2021-01-13 最終更新日 2024-11-06 実験手法 SOLUTION NMR 主引用文献 Conus venom fractions inhibit the adhesion of Plasmodium falciparum erythrocyte membrane protein 1 domains to the host vascular receptors. J Proteomics, 234, 2020
7ZB0	macrocyclase OphP with 15mer 分子名称: 1,2-ETHANEDIOL, 15mer, BICARBONATE ION, ... 著者 Song, H, Naismith, J.H. 登録日 2022-03-23 公開日 2022-07-06 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Molecular basis for the enzymatic macrocyclization of multiply backbone N-methylated peptides Biorxiv, 2022

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