PDB: 219038 件ウェブページステータス検索Chemie searchBIRD

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1MX0	Structure of topoisomerase subunit 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... 著者 Corbett, K.D, Berger, J.M. 登録日 2002-10-01 公開日 2003-01-07 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution Embo J., 22, 2003
4AUL	Crystal structure, recombinant expression and mutagenesis studies of the bifunctional catalase-phenol oxidase from Scytalidium thermophilum 分子名称: CALCIUM ION, CATALASE-PHENOL OXIDASE, PROTOPORPHYRIN IX CONTAINING FE 著者 Yuzugullu, Y, Trinh, C.H, Smith, M.A, Pearson, A.R, Phillips, S.E.V, Sutay Kocabas, D, Bakir, U, Ogel, Z.B, McPherson, M.J. 登録日 2012-05-18 公開日 2013-02-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure, Recombinant Expression and Mutagenesis Studies of the Catalase with Oxidase Activity from Scytalidium Thermophilum Acta Crystallogr.,Sect.D, 69, 2013
1SOJ	CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, cGMP-inhibited 3',5'-cyclic phosphodiesterase B 著者 Scapin, G, Patel, S.B, Chung, C, Varnerin, J.P, Edmondson, S.D, Mastracchio, A, Parmee, E.R, Becker, J.W, Singh, S.B, Van Der Ploeg, L.H, Tota, M.R. 登録日 2004-03-15 公開日 2004-05-11 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity Biochemistry, 43, 2004
1SHX	Ephrin A5 ligand structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin-A5 著者 Himanen, J.P, Barton, W.A, Nikolov, D.B, Jeffrey, P.D. 登録日 2004-02-26 公開日 2005-04-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. J.Biol.Chem., 280, 2005
3CHB	CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLERA TOXIN, UNKNOWN ATOM OR ION, ... 著者 Merritt, E.A, Hol, W.G.J. 登録日 1998-03-24 公開日 1998-08-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. J.Mol.Biol., 282, 1998
1N59	Crystal structure of the Murine class I Major Histocompatibility Complex of H-2KB, B2-Microglobulin, and A 9-Residue immunodominant peptide epitope gp33 derived from LCMV 分子名称: Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... 著者 Achour, A, Michaelsson, J, Harris, R.A, Odeberg, J, Grufman, P, Sandberg, J.K, Levitsky, V, Karre, K, Sandalova, T, Schneider, G. 登録日 2002-11-05 公開日 2003-01-07 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 A Structural Basis for LCMV Immune Evasion. Subversion of H-2D(b) and H-2K(b) Presentation of gp33 Revealed by Comparative Crystal Structure Analyses. Immunity, 17, 2002
1N5A	Crystal structure of the Murine class I Major Histocompatibility Complex of H-2DB, B2-Microglobulin, and A 9-Residue immunodominant peptide epitope gp33 derived from LCMV 分子名称: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... 著者 Achour, A, Michaelsson, J, Harris, R.A, Odeberg, J, Grufman, P, Sandberg, J.K, Levitsky, V, Karre, K, Sandalova, T, Schneider, G. 登録日 2002-11-05 公開日 2003-01-07 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 A Structural Basis for LCMV Immune Evasion. Subversion of H-2D(b) and H-2K(b) Presentation of gp33 Revealed by Comparative Crystal Structure Analyses. Immunity, 17, 2002
1IXP	Enzyme-phosphate Complex of Pyridoxine 5'-Phosphate synthase 分子名称: PHOSPHATE ION, Pyridoxine 5'-Phosphate synthase 著者 Garrido-Franco, M, Laber, B, Huber, R, Clausen, T. 登録日 2002-06-28 公開日 2003-02-11 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis J.MOL.BIOL., 321, 2002
3HC8	Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System. 分子名称: 6-(6-methoxypyridin-3-yl)-2-[(2-morpholin-4-ylethyl)amino]-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3(4H)-one, MAGNESIUM ION, ZINC ION, ... 著者 Hughes, R.O, Stallings, W.C, Cubbage, J.W, Williams, J.M. 登録日 2009-05-05 公開日 2009-07-07 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. Bioorg.Med.Chem.Lett., 19, 2009
1D98	THE STRUCTURE OF AN OLIGO(DA).OLIGO(DT) TRACT AND ITS BIOLOGICAL IMPLICATIONS 分子名称: DNA (5'-D(*CP*GP*CP*AP*AP*AP*AP*AP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*TP*TP*TP*TP*TP*GP*CP*G)-3') 著者 Nelson, H.C.M, Finch, J.T, Luisi, B.F, Klug, A. 登録日 1992-10-17 公開日 1993-04-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The structure of an oligo(dA).oligo(dT) tract and its biological implications. Nature, 330, 1987
1SGY	TYR 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5 分子名称: Ovomucoid, PHOSPHATE ION, Streptogrisin B 著者 Huang, K, Lu, W, Anderson, S, Laskowski Jr, M, James, M.N.G. 登録日 1999-03-25 公開日 2003-08-26 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recruitment of a Buried K+ Ion to Stabilize the Negative Charge of Ionized P1 in the Hydrophobic Pocket: Crystal Structures of Glu18, Gln18, Asp18 and Asn18 Variants of Turkey Ovomucoid Inhibitor Third Domain Complexed with Streptomyces griseus Protease B at Various pH's To be Published
1S3B	Crystal structure of MAOB in complex with N-methyl-N-propargyl-1(R)-aminoindan 分子名称: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, N-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YL]-N-METHYL-N-PROP-2-YNYLAMINE 著者 Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A. 登録日 2004-01-13 公開日 2004-03-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class. J.Med.Chem., 47, 2004
1S2Q	Crystal structure of MAOB in complex with N-propargyl-1(R)-aminoindan (Rasagiline) 分子名称: (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE 著者 Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A. 登録日 2004-01-09 公開日 2004-03-30 最終更新日 2012-02-22 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class. J.Med.Chem., 47, 2004
1S2Y	Crystal structure of MAOB in complex with N-propargyl-1(S)-aminoindan 分子名称: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN 著者 Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A. 登録日 2004-01-12 公開日 2004-03-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class. J.Med.Chem., 47, 2004
198D	A TRIGONAL FORM OF THE IDARUBICIN-D(CGATCG) COMPLEX: CRYSTAL AND MOLECULAR STRUCTURE AT 2.0 ANGSTROMS RESOLUTION 分子名称: DNA (5'-D(*CP*GP*AP*TP*CP*G)-3'), IDARUBICIN, SPERMINE 著者 Dautant, A, Langlois D'Estaintot, B, Gallois, B, Brown, T, Hunter, W.N. 登録日 1994-11-28 公開日 1995-03-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 A resolution. Nucleic Acids Res., 23, 1995
4GEB	Kynurenine Aminotransferase II Inhibitors 分子名称: (5-hydroxy-4-{[(7-hydroxy-6-oxo-2-phenyl-6,7-dihydro-2H-pyrazolo[3,4-b]pyridin-5-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, ... 著者 Pandit, J. 登録日 2012-08-01 公開日 2013-03-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg.Med.Chem.Lett., 23, 2013
1NHT	ENTRAPMENT OF 6-THIOPHOSPHORYL-IMP IN THE ACTIVE SITE OF CRYSTALLINE ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI DATA COLLECTED AT 100K 分子名称: 2-DEAZO-6-THIOPHOSPHATE GUANOSINE-5'-MONOPHOSPHATE, ADENYLOSUCCINATE SYNTHETASE, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Poland, B.W, Bruns, C.A, Fromm, H.J, Honzatko, R.B. 登録日 1997-01-12 公開日 1997-10-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Entrapment of 6-thiophosphoryl-IMP in the active site of crystalline adenylosuccinate synthetase from Escherichia coli. J.Biol.Chem., 272, 1997
1N8C	Solution Structure of a Cis-Opened (10R)-N6-Deoxyadenosine Adduct of (9S,10R)-(9,10)-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA Duplex 分子名称: (9S,10R)-9-HYDROXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE, 5'-D(*CP*CP*TP*CP*GP*TP*GP*AP*CP*CP*G)-3', 5'-D(*CP*GP*GP*TP*CP*AP*CP*GP*AP*GP*G)-3' 著者 Volk, D.E, Thiviyanathan, V, Rice, J.S, Luxon, B.A, Shah, J.H, Yagi, H, Sayer, J.M, Yeh, H.J.C, Jerina, D.M, Gorenstein, D.G. 登録日 2002-11-20 公開日 2003-02-14 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution Structure of a Cis-Opened (10R)-N6-Deoxyadenosine Adduct of (9S,10R)-(9,10)-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA Duplex Biochemistry, 42, 2003
1DDP	Solution structure of a CISPLATIN-INDUCED [CATAGCTATG]2 Interstrand cross-link 分子名称: Cisplatin, DNA (5'-D(*CP*AP*TP*AP*GP*CP*TP*AP*TP*G)-3') 著者 Zhu, L, Huang, H, Reid, B.R, Drobny, G.P, Hopkins, P.B. 登録日 1995-10-26 公開日 1996-03-08 最終更新日 2024-03-13 実験手法 SOLUTION NMR 主引用文献 Solution structure of a cisplatin-induced DNA interstrand cross-link. Science, 270, 1995
7B3P	Notum complex with ARUK3003775 分子名称: 1,2-ETHANEDIOL, 6-((4-chlorophenyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2020-12-01 公開日 2021-12-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
7B3X	Notum complex with ARUK3003748 分子名称: 6-(m-tolylthio)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Fish, P, Jones, E.Y. 登録日 2020-12-01 公開日 2021-12-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
7EPB	Cryo-EM structure of LY354740-bound mGlu2 homodimer 分子名称: (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, Anti-RON nanobody, Metabotropic glutamate receptor 2 著者 Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. 登録日 2021-04-26 公開日 2021-06-23 最終更新日 2021-07-07 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
7B45	Notum complex with ARUK3003934 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(3-methylsulfanylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one, ... 著者 Fish, P, Jones, E.Y. 登録日 2020-12-02 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
3N7S	Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism 分子名称: Calcitonin gene-related peptide type 1 receptor, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, N~4~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~2~-1H-indazol-5-yl-6-methylpyrimidine-2,4-diamine, ... 著者 Ter Haar, E. 登録日 2010-05-27 公開日 2010-09-15 最終更新日 2022-10-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18, 2010
1EW3	CRYSTAL STRUCTURE OF THE MAJOR HORSE ALLERGEN EQU C 1 分子名称: ALLERGEN EQU C 1 著者 Lascombe, M.B, Gregoire, C, Poncet, P, Tavares, G.A, Rosinski-Chupin, I, Rabillon, J, Goubran-Botros, H, Mazie, J.C, David, B, Alzari, P.M. 登録日 2000-04-21 公開日 2000-05-03 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes. J.Biol.Chem., 275, 2000

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