PDB: 11187 件ウェブページステータス検索Chemie searchBIRD

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3H5U	Hepatitis C virus polymerase NS5B with saccharin inhibitor 1 分子名称: N-({3-[(5S)-5-tert-butyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzisothiazol-7-yl}methyl)methanesulfonamide, RNA-directed RNA polymerase 著者 Harris, S.F, Ghate, M. 登録日 2009-04-22 公開日 2009-09-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides Bioorg.Med.Chem.Lett., 19, 2009
3EJP	Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5R)-5-[2'-oxo-2'-(phenyl)ethyl]-swainsonine 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-phenyl-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2008-09-18 公開日 2009-10-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. Chembiochem, 11, 2010
4KNM	Crystal structure of human carbonic anhydrase isozyme XIII with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide 分子名称: 2-chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, Carbonic anhydrase 13, TRIETHYLENE GLYCOL, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2013-05-10 公開日 2013-11-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Bioorg.Med.Chem., 21, 2013
4KPP	Crystal Structure of H+/Ca2+ Exchanger CAX 分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, OLEIC ACID, ... 著者 Nishizawa, T, Ishitani, R, Nureki, O. 登録日 2013-05-14 公開日 2013-06-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger. Science, 341, 2013
4KRR	Crystal structure of Drosophila WntD N-terminal domain-linker (residues 31-240) 分子名称: GLYCEROL, SODIUM ION, Wnt inhibitor of Dorsal protein 著者 Chu, M.L.-H, Choi, H.-J, Ahn, V.E, Daniels, D.L, Nusse, R, Weis, W.I. 登録日 2013-05-16 公開日 2013-07-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.124 Å) 主引用文献 Structural Studies of Wnts and Identification of an LRP6 Binding Site. Structure, 21, 2013
4KNN	Crystal structure of human carbonic anhydrase isozyme XIII with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide 分子名称: 1,2-ETHANEDIOL, 2-chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide, ACETIC ACID, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2013-05-10 公開日 2013-11-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.404 Å) 主引用文献 Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Bioorg.Med.Chem., 21, 2013
4KP0	Crystal Structure of the human Chymase with TJK002 分子名称: 4-({1-[(4-methyl-1-benzothiophen-3-yl)methyl]-1H-benzimidazol-2-yl}sulfanyl)butanoic acid, Chymase 著者 Kakuda, S, Takimoto-Kamimura, M. 登録日 2013-05-12 公開日 2013-10-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor J.SYNCHROTRON RADIAT., 20, 2013
2M1E	Biosynthetic engineered B28K-B29P human insulin monomer structure in in water solutions. 分子名称: Insulin 著者 Bocian, W, Kozerski, L. 登録日 2012-11-26 公開日 2013-02-27 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions. J.Biomol.Nmr, 55, 2013
5ZKG	Crystal Structure of C-terminal Domain of Plasmodium vivax p43 分子名称: Aminoacyl-tRna synthetase-interacting multifunctional protein P43 著者 Gupta, S, Sharma, M, Manickam, Y, Sharma, A. 登録日 2018-03-23 公開日 2019-04-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein. Acta Crystallogr D Struct Biol, 76, 2020
3MWK	Q28E mutant of HERA N-terminal RecA-like domain, complex with 8-oxo-AMP 分子名称: Heat resistant RNA dependent ATPase, SULFATE ION, [(2R,3S,4R,5R)-5-(6-azanyl-8-oxo-7H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate 著者 Rudolph, M.G, Klostermeier, D. 登録日 2010-05-06 公開日 2011-03-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop. Biol.Chem., 392, 2011
5ZH4	CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-7 分子名称: (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... 著者 Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. 登録日 2018-03-11 公開日 2018-06-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
5ZDK	Crystal Structure Analysis of TtQRS in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CESIUM ION, CHLORIDE ION, ... 著者 Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J. 登録日 2018-02-23 公開日 2018-12-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes Int. J. Biol. Macromol., 120, 2018
5Z5S	Crystal structure of the PPARgamma-LBD complexed with compound 13ab 分子名称: 3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... 著者 Matsui, Y, Hanzawa, H. 登録日 2018-01-19 公開日 2018-10-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of DS-6930, a potent selective PPAR gamma modulator. Part I: Lead identification. Bioorg. Med. Chem., 26, 2018
5ELO	Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and cladosporin 分子名称: 1,2-ETHANEDIOL, LYSINE, Lysine--tRNA ligase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2015-11-04 公開日 2016-11-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc. Natl. Acad. Sci. U.S.A., 2019
5ZKF	Crystal Structure of N-terminal Domain of Plasmodium vivax p43 in space group P21 分子名称: Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein p43 著者 Gupta, S, Sharma, M, Harlos, K, Manickam, Y, Sharma, A. 登録日 2018-03-23 公開日 2019-04-24 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein. Acta Crystallogr D Struct Biol, 76, 2020
5EIU	Mini TRIM5 B-box 2 dimer C2 crystal form 分子名称: TRIM protein-E3 ligase Chimera, ZINC ION 著者 Wagner, J.M, Doss, G, Pornillos, O. 登録日 2015-10-30 公開日 2016-06-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.908 Å) 主引用文献 Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5 alpha. Elife, 5, 2016
5ZS9	SufS from Bacillus subtilis in the resting state 分子名称: Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER 著者 Nakamura, R, Fujishiro, T, Takahashi, Y. 登録日 2018-04-28 公開日 2019-05-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes. Febs J., 287, 2020
3NEJ	Q28E mutant of Hera RNA helicase N-terminal domain - perfectly twinned hexagonal form 分子名称: Heat resistant RNA dependent ATPase 著者 Rudolph, M.G. 登録日 2010-06-09 公開日 2011-04-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop. Biol.Chem., 392, 2011
6AAG	Crystal structure of budding yeast Atg8 complexed with the helical AIM of Hfl1. 分子名称: Transmembrane protein 184 homolog YKR051W,Autophagy-related protein 8 著者 Yamasaki, A, Noda, N.N. 登録日 2018-07-18 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.445 Å) 主引用文献 Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein Elife, 7, 2018
6AAF	Crystal structure of fission yeast Atg8 complexed with the helical AIM of Hfl1. 分子名称: Autophagy-related protein 8, Transmembrane protein 184 homolog C30D11.06c 著者 Yamasaki, A, Noda, N.N. 登録日 2018-07-18 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.197 Å) 主引用文献 Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein Elife, 7, 2018
5ZST	NifS from Hydrogenimonas thermopile in a persulfurated form 分子名称: Cysteine desulfurase 著者 Nakamura, R, Fujishiro, T, Takahashi, Y. 登録日 2018-04-29 公開日 2019-05-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes. Febs J., 287, 2020
5EYA	TRIM25 RING domain in complex with Ubc13-Ub conjugate 分子名称: Polyubiquitin-B, Tripartite motif-containing 25 variant, Ubiquitin-conjugating enzyme E2 N, ... 著者 Pornillos, O, Sanchez, J.G. 登録日 2015-11-24 公開日 2016-08-17 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway. Cell Rep, 16, 2016
5EW3	Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993 分子名称: 2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide, Vascular endothelial growth factor receptor 2 著者 Stark, W, Goepfert, A. 登録日 2015-11-20 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis. J.Med.Chem., 59, 2016
1KRU	Galactoside Acetyltransferase in Complex with IPTG and Coenzyme A 分子名称: 1-methylethyl 1-thio-beta-D-galactopyranoside, COENZYME A, GALACTOSIDE O-ACETYLTRANSFERASE 著者 Wang, X.-G, Olsen, L.R, Roderick, S.L. 登録日 2002-01-10 公開日 2002-04-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the lac operon galactoside acetyltransferase. Structure, 10, 2002
6A9E	Crystal structure of the N-terminal domain of Atg2 分子名称: Endolysin,Autophagy-related protein 2 著者 Osawa, T, Noda, N.N. 登録日 2018-07-13 公開日 2019-03-20 最終更新日 2019-04-17 実験手法 X-RAY DIFFRACTION (3.205 Å) 主引用文献 Atg2 mediates direct lipid transfer between membranes for autophagosome formation. Nat. Struct. Mol. Biol., 26, 2019

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