6YP3
 
 | | 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-028 | | 分子名称: | 1-(4-methylphenyl)-1,2,4-triazole, 14-3-3 protein sigma, CHLORIDE ION, ... | | 著者 | Wolter, M, Ottmann, C. | | 登録日 | 2020-04-15 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering.
Angew.Chem.Int.Ed.Engl., 59, 2020
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8FKQ
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6YPD
 | | Crystal structure of AmpC from E. coli with Cyclic Boronate 3 (CB3 / APC308) | | 分子名称: | (3~{S})-2,2-bis(oxidanyl)-3-(phenylmethylsulfanyl)-3,4-dihydro-1,2-benzoxaborinin-2-ium-8-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase, ... | | 著者 | Lang, P.A, Brem, J, Schofield, C.J. | | 登録日 | 2020-04-15 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli .
Biomolecules, 10, 2020
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8AHE
 | | PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery | | 分子名称: | SULFATE ION, UDP-N-acetylglucosamine 2-epimerase, ~{N},5-dimethyl-1-phenyl-pyrazole-4-sulfonamide | | 著者 | Baker, L.M, Murray, J.B, Hubbard, R.E. | | 登録日 | 2022-07-21 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.108 Å) | | 主引用文献 | PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.
Rsc Med Chem, 13, 2022
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8AHF
 | | PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery | | 分子名称: | (2~{R},4~{S})-4-[bis(fluoranyl)methoxy]-~{N}-methyl-1-(2~{H}-pyrazolo[4,3-b]pyridin-6-ylcarbonyl)pyrrolidine-2-carboxamide, SULFATE ION, UDP-N-acetylglucosamine 2-epimerase | | 著者 | Baker, L.M, Murray, J.B, Hubbard, R.E. | | 登録日 | 2022-07-21 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.271 Å) | | 主引用文献 | PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.
Rsc Med Chem, 13, 2022
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9B3G
 | | Human Notch-1 EGFs 21-23 | | 分子名称: | BARIUM ION, Neurogenic locus notch homolog protein 1 | | 著者 | Johnson, S, Sheppard, D, Handford, P.A, Lea, S.M. | | 登録日 | 2024-03-19 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-12-18 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation.
Structure, 32, 2024
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5EP7
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8IP8
 | | Wheat 80S ribosome stalled on AUG-Stop boron dependently | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein eL8, 40S ribosomal protein eS1, ... | | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | | 登録日 | 2023-03-14 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Nat.Chem.Biol., 20, 2024
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9RJ0
 | | SARS-CoV-2 with a bound inhibitor | | 分子名称: | 1-(benzimidazol-1-yl)-3-[(4~{S})-6-fluoranyl-3,4-dihydro-2~{H}-thiochromen-4-yl]urea, 3C-like proteinase nsp5, SODIUM ION | | 著者 | Mac Sweeney, A. | | 登録日 | 2025-06-12 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (1.709 Å) | | 主引用文献 | SARS-CoV-2 with a bound inhibitor
To Be Published
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8Q3D
 | | HsNMT1 in complex with both MyrCoA and GNCFSKPR(NH2) inhibitor peptide | | 分子名称: | CHLORIDE ION, COENZYME A, GLYCEROL, ... | | 著者 | Dian, C, Giglione, C, Meinnel, T. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-14 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Novel, tightly structurally related N-myristoyltransferase inhibitors display equally potent yet distinct inhibitory mechanisms.
Structure, 32, 2024
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6X21
 | | Crystal structure of PT1673 bound to HIF2a-B*:ARNT-B* complex | | 分子名称: | 1-(3-bromo-5-fluorophenoxy)-4-[(difluoromethyl)sulfonyl]-2-nitrobenzene, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | | 著者 | Du, X. | | 登録日 | 2020-05-19 | | 公開日 | 2021-05-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Crystal structure of PT1673 bound to HIF2a-B*:ARNT-B* complex
To Be Published
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6QVA
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9RM6
 | | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0027808 | | 分子名称: | 6-chloranyl-~{N}-(2,3-dihydro-1~{H}-isoindol-5-yl)-1~{H}-indazole-4-carboxamide, DIMETHYL SULFOXIDE, SULFATE ION, ... | | 著者 | Ni, X, Marples, P.G, Godoy, A.S, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Fairhead, M, Lithgo, R.M, Lee, A, Kenton, N, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Williams, E.P, Fearon, D, von Delft, F. | | 登録日 | 2025-06-17 | | 公開日 | 2025-07-23 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0027808
To Be Published
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7V1I
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8OWJ
 | | Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2 | | 分子名称: | Amyloid-beta A4 protein | | 著者 | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | | 登録日 | 2023-04-28 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | | 主引用文献 | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
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7RLV
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8Q3S
 | | HsNMT1 in complex with both MyrCoA and GNCFSKAR inhibitor peptide | | 分子名称: | CHLORIDE ION, COENZYME A, GLY-ASN-CYS-PHE-SER-LYS-ALA-ARG, ... | | 著者 | Dian, C, Giglione, C, Meinnel, T. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-14 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Novel, tightly structurally related N-myristoyltransferase inhibitors display equally potent yet distinct inhibitory mechanisms.
Structure, 32, 2024
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8Q3T
 | | HsNMT1 in complex with both MyrCoA and GNCFSKPRVPTK inhibitor peptide | | 分子名称: | CHLORIDE ION, COENZYME A, GLYCEROL, ... | | 著者 | Dian, C, Giglione, C, Meinnel, T. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-14 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Novel, tightly structurally related N-myristoyltransferase inhibitors display equally potent yet distinct inhibitory mechanisms.
Structure, 32, 2024
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8Q2Z
 | | HsNMT1 in complex with both MyrCoA and GNLLSKFR peptide | | 分子名称: | CHLORIDE ION, COENZYME A, GLYCEROL, ... | | 著者 | Dian, C, Giglione, C, Meinnel, T. | | 登録日 | 2023-08-03 | | 公開日 | 2024-08-14 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Novel, tightly structurally related N-myristoyltransferase inhibitors display equally potent yet distinct inhibitory mechanisms.
Structure, 32, 2024
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7UGI
 | | Bromodomain of EP300 liganded with BMS-536924 | | 分子名称: | (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ... | | 著者 | Schonbrunn, E, Bikowitz, M. | | 登録日 | 2022-03-24 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis of CBP and EP300 interaction with kinase inhibitors
To Be Published
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8E77
 | | rystal structure of Pcryo_0616, the aminotransferase required to synthesize UDP-N-acetyl-3-amino-D-glucosaminuronic acid (UDP-GlcNAc3NA), incomplete with its external aldimine reaction intermediate | | 分子名称: | (2S,3S,4R,5R,6R)-5-(acetylamino)-6-{[(R)-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-3-hydroxy-4-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}tetrahydro-2H-pyran-2-carboxylic acid (non-preferred name), 1,2-ETHANEDIOL, DegT/DnrJ/EryC1/StrS aminotransferase, ... | | 著者 | Hofmeister, D.L, Seltzner, C.A, Bockhaus, N.J, Thoden, J.B, Holden, H.M. | | 登録日 | 2022-08-23 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Investigation of the enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-d-glucuronic acid in Psychrobacter cryohalolentis K5 T.
Protein Sci., 32, 2023
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6R6I
 | | Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue | | 分子名称: | 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, PHOSPHATE ION, Transthyretin | | 著者 | Loconte, V, Menozzi, I, Ferrari, A, Berni, R, Zanotti, G. | | 登録日 | 2019-03-27 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.467 Å) | | 主引用文献 | Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin.
J.Struct.Biol., 208, 2019
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8OVM
 | | Lipidic amyloid-beta(1-40) fibril - polymorph L2 | | 分子名称: | Amyloid-beta A4 protein | | 著者 | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | | 登録日 | 2023-04-26 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
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8OFM
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6IRD
 | | Complex structure of INADL PDZ89 and PLCb4 C-terminal CC-PBM | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, GOLD ION, InaD-like protein | | 著者 | Ye, F, Li, J, Huang, Y, Liu, W, Zhang, M. | | 登録日 | 2018-11-12 | | 公開日 | 2019-01-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.813 Å) | | 主引用文献 | An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors.
Elife, 7, 2018
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