PDB: 244693 件ウェブページステータス検索Chemie searchBIRD

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6OUM	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB10-580B 分子名称: (2Z)-2-(hydroxyimino)-2,3-dihydro-1,3-benzoxazole-5-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Kota, A, McKenna, R. 登録日 2019-05-04 公開日 2020-05-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.559 Å) 主引用文献 Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-580B To Be Published
8Q7E	Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly 分子名称: Cullin-9, E3 ubiquitin-protein ligase RBX1 著者 Hopf, L.V.M, Horn-Ghetko, D, Schulman, B.A. 登録日 2023-08-16 公開日 2024-04-17 最終更新日 2024-07-31 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. Nat.Struct.Mol.Biol., 31, 2024
5IUI	Crystal Structure of Anaplastic Lyphoma Kinase (ALK) in complex with 4 分子名称: ALK tyrosine kinase receptor, N-[3-(4-amino-3-methylphenyl)-1H-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide 著者 Tu, C.H, Wu, S.Y. 登録日 2016-03-18 公開日 2016-05-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK). J.Med.Chem., 59, 2016
6OAG	Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02-82 分子名称: Farnesyl pyrophosphate synthase, PHOSPHATE ION, [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid 著者 Park, J, Berghuis, A.M. 登録日 2019-03-16 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J.Med.Chem., 62, 2019
6IPB	Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15 分子名称: GLYCEROL, L(+)-TARTARIC ACID, UDP-glucuronosyltransferase 2B15 著者 Zhang, L, Xie, W, Wang, C. 登録日 2018-11-02 公開日 2020-01-15 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem. Pharmacol., 172, 2019
5JNW	Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with vanadate and uncompetitive inhibitor 分子名称: 2-(4-{[3-(piperidin-1-yl)propyl]amino}quinolin-2-yl)benzonitrile, Low molecular weight phosphotyrosine protein phosphatase, VANADATE ION 著者 Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. 登録日 2016-04-30 公開日 2017-03-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
5NON	Structure of truncated Norcoclaurine Synthase from Thalictrum flavum with product mimic 分子名称: 4-[2-[2-(4-methoxyphenyl)ethylamino]ethyl]benzene-1,2-diol, S-norcoclaurine synthase 著者 Sula, A, Lichman, B.R, Pesnot, T, Ward, J.M, Hailes, H.C, Keep, N.H. 登録日 2017-04-12 公開日 2017-09-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase. Biochemistry, 56, 2017
5IXV	Crystal structure of the signaling protein complex 2 分子名称: 1-METHYLIMIDAZOLE, Alr2278 protein, MALONATE ION, ... 著者 Kumar, V, van den Akker, F. 登録日 2016-03-23 公開日 2017-08-09 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the signaling protein complex 2 To Be Published
8DBV	E. coli ATP synthase imaged in 10mM MgATP State3 "down 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Sobti, M, Stewart, A.G. 登録日 2022-06-14 公開日 2023-01-25 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Changes within the central stalk of E. coli F 1 F o ATP synthase observed after addition of ATP. Commun Biol, 6, 2023
6IVM	Crystal structure of a membrane protein P143A 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... 著者 Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. 登録日 2018-12-04 公開日 2019-11-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
8EKR	Apo rat TRPV2 in nanodiscs, state 3 分子名称: 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Transient receptor potential cation channel subfamily V member 2 著者 Pumroy, R.A, Moiseenkova-Bell, V.Y. 登録日 2022-09-21 公開日 2023-09-27 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Functional and structural insights into activation of TRPV2 by weak acids. Embo J., 43, 2024
5I39	High resolution structure of L-amino acid deaminase from Proteus vulgaris with the deletion of the specific insertion sequence 分子名称: 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid deaminase 著者 Zhou, H, Ju, Y, Niu, L, Teng, M. 登録日 2016-02-10 公開日 2016-08-03 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris J.Struct.Biol., 195, 2016
8EKQ	Apo rat TRPV2 in nanodiscs, state 2 分子名称: 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Transient receptor potential cation channel subfamily V member 2 著者 Pumroy, R.A, Moiseenkova-Bell, V.Y. 登録日 2022-09-21 公開日 2023-09-27 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Functional and structural insights into activation of TRPV2 by weak acids. Embo J., 43, 2024
9E83	TMPRSS2 crystal structure following acylation by UCSF_157 分子名称: 1,2-ETHANEDIOL, 4-(2-aminoethyl)benzoic acid, CITRIC ACID, ... 著者 Fraser, B.J, Dong, A, Seitova, A, Li, Y, Hutchinson, A, Young, N, Bender, B, Gahbauer, S, Edwards, A, Shoichet, B, Craik, C, Arrowsmith, C.H. 登録日 2024-11-04 公開日 2024-12-25 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 High resolution TMPRSS2 structure following acylation by nafamostat To Be Published
6HXL	Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH (space group P21) 分子名称: 1,2-ETHANEDIOL, ATP-citrate synthase, CITRATE ANION, ... 著者 Verstraete, K, Verschueren, K. 登録日 2018-10-17 公開日 2019-04-10 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019
9I7E	Crystal structure of HRP-2 PWWP domain with C64S mutation - Crystal form P1 type 2 分子名称: 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2 著者 Vantieghem, T, Osipov, E.M, Strelkov, S.V. 登録日 2025-01-31 公開日 2025-08-13 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal engineering of the hepatoma-derived growth factor-related protein 2 PWWP domain towards crystallographic fragment screening. Acta Crystallogr.,Sect.F, 81, 2025
8BIJ	O-Methyltransferase Plu4894 (mutant I88M, W91L, C97Y, S142L, G146V, Y258M, L270F, S309Y) in complex with SAH 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Methyltransferase Plu4894 mutant I88M, ... 著者 Huber, E.M, Groll, M. 登録日 2022-11-02 公開日 2023-03-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments. Structure, 31, 2023
8BIR	O-Methyltransferase Plu4895 in complex with SAH and AQ-256 分子名称: 1,3,8-tris(oxidanyl)anthracene-9,10-dione, CHLORIDE ION, IODIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2022-11-02 公開日 2023-03-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments. Structure, 31, 2023
8HCC	Crystal structure of mTREX1-RNA product complex (AMP) 分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, SODIUM ION, ... 著者 Hsiao, Y.Y, Huang, K.W, Wu, C.Y. 登録日 2022-11-01 公開日 2023-11-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
8EI8	Crystal structure of the WWP2 HECT domain in complex with H308, a Helicon Polypeptide 分子名称: 1,2-ETHANEDIOL, H308, N,N'-(1,4-phenylene)diacetamide, ... 著者 Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. 登録日 2022-09-14 公開日 2023-10-25 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
6IVX	Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. 分子名称: (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 著者 Noguchi, M, Nomura, A, Doi, S, Adachi, T. 登録日 2018-12-04 公開日 2019-03-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. J. Med. Chem., 62, 2019
9GV7	Structure of reverse docking TCR in complex with peptide-HLA 分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ... 著者 Karuppiah, V. 登録日 2024-09-23 公開日 2025-04-23 最終更新日 2025-04-30 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Determining T-cell receptor binding orientation and Peptide-HLA interactions using cross-linking mass spectrometry. J.Biol.Chem., 301, 2025
6I73	Structure of Fragaria ananassa O-methyltransferase in complex with S-adenosylhomocysteine and protocatechuic aldehyde 分子名称: 1,2-ETHANEDIOL, O-methyltransferase, Protocatechuic aldehyde, ... 著者 Heldner, A, Schiefner, A. 登録日 2018-11-15 公開日 2019-11-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural insights into enzymatic formation of the strawberry flavor compound 2,5-dimethyl-4-methoxy-3(2H)-furanone To Be Published
6I5D	Crystal structure of an OXA-48 beta-lactamase synthetic mutant 分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... 著者 Zavala, A, Retailleau, P, Dabos, L, Naas, T, Iorga, B. 登録日 2018-11-13 公開日 2020-03-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Substrate specificity of an OXA-48 beta-lactamase synthetic mutant To be published
9FDL	Crystal structure of the catalytic domain of an AA9 lytic polysaccharide monooxygenase from Thermothelomyces thermophilus (TtLPMO9F) 分子名称: 1,2-ETHANEDIOL, COPPER (II) ION, DI(HYDROXYETHYL)ETHER, ... 著者 Kosinas, C, Dimarogona, M, Topakas, E. 登録日 2024-05-17 公開日 2024-12-25 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Mutational study of a lytic polysaccharide monooxygenase from Myceliophthora thermophila (MtLPMO9F): Structural insights into substrate specificity and regioselectivity. Int.J.Biol.Macromol., 288, 2024

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