PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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5D7Y	Crystal structure of Hepatitis B virus T=4 capsid in complex with the allosteric modulator HAP18 分子名称: Capsid protein, methyl (4R)-4-(2-chloro-4-fluorophenyl)-6-{[4-(3-hydroxypenta-1,4-diyn-3-yl)piperidin-1-yl]methyl}-2-(pyridin-2-yl)-1,4-dihydropyrimidine-5-carboxylate 著者 Venkatakrishnan, B, Katen, S.P, Zlotnick, A. 登録日 2015-08-14 公開日 2016-02-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.894 Å) 主引用文献 Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket. J.Virol., 90, 2016
3NOU	Light-induced intermediate structure L3 of P. aeruginosa bacteriophytochrome 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome 著者 Yang, X, Ren, Z, Moffat, K. 登録日 2010-06-25 公開日 2012-11-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Temperature-scan cryocrystallography reveals reaction intermediates in bacteriophytochrome. Nature, 479, 2011
3NOP	Light-induced intermediate structure L1 of Pseudomonas aeruginosa bacteriophytochrome 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome 著者 Yang, X, Ren, Z, Moffat, K. 登録日 2010-06-25 公開日 2012-11-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Temperature-scan cryocrystallography reveals reaction intermediates in bacteriophytochrome. Nature, 479, 2011
5E4F	The spring alpha-helix coordinates multiple modes of HCV NS3 helicase action 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine protease NS3, ... 著者 Gu, M, Rice, C.M. 登録日 2015-10-05 公開日 2016-05-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Spring alpha-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action. J.Biol.Chem., 291, 2016
6SL0	Complete CtTel1 dimer with C2 symmetry 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 著者 Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. 登録日 2019-08-16 公開日 2019-10-30 最終更新日 2020-01-15 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
6TMX	Structure of the chaperonin gp146 from the bacteriophage EL (Pseudomonas aeruginosa) in complex with ATPgammaS 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, POTASSIUM ION, ... 著者 Bracher, A, Wang, H, Paul, S.S, Wischnewski, N, Hartl, F.U, Hayer-Hartl, M. 登録日 2019-12-05 公開日 2020-04-22 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Structure and conformational cycle of a bacteriophage-encoded chaperonin. Plos One, 15, 2020
5HH6	Crystal structure of B3 metallo-beta-lactamase L1 in complex with a phosphonate-based inhibitor 分子名称: 6-[(~{S})-oxidanyl(phosphono)methyl]pyridine-2-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ... 著者 Hinchliffe, P, Spencer, J. 登録日 2016-01-09 公開日 2017-01-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57, 2018
6VSH	Crystal structure of apo Dicamba Monooxygenase 分子名称: Dicamba O-demethylase, oxygenase component, FE2/S2 (INORGANIC) CLUSTER 著者 Rydel, T.J. 登録日 2020-02-11 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Dicamba monooxygenase: structural insights into a dynamic Rieske oxygenase that catalyzes an exocyclic monooxygenation. J. Mol. Biol., 392, 2009
5HH5	Crystal structure of B3 metallo-beta-lactamase L1 complexed with a phosphonate-based inhibitor 分子名称: 6-(phosphonomethyl)pyridine-2-carboxylic acid, GLYCEROL, Metallo-beta-lactamase L1, ... 著者 Hinchliffe, P, Spencer, J. 登録日 2016-01-09 公開日 2017-01-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57, 2018
3PM1	Structure of QacR E90Q bound to Ethidium 分子名称: ETHIDIUM, HTH-type transcriptional regulator qacR, SULFATE ION 著者 Schumacher, M.A. 登録日 2010-11-15 公開日 2011-07-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. Plos One, 6, 2011
4E5O	Crystal structure of mouse thymidylate synthase in complex with dUMP 分子名称: 1,4-BUTANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase 著者 Dowiercial, A, Jarmula, A, Rypniewski, W, Sokolowska, M, Fraczyk, T, Ciesla, J, Rode, W. 登録日 2012-03-14 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme Struct Chem, 2016
4GM0	Crystal Structure of Benzoylformate Decarboxylase Mutant L403N 分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ... 著者 Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J. 登録日 2012-08-15 公開日 2013-05-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.07 Å) 主引用文献 A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate. Biochemistry, 52, 2013
8JBA	Discovery and Crystallography Study of Novel Oxadiazole Analogs as Small Molecule PD-1/PD-L1 inhibitors 分子名称: (2~{S})-2-[[3-[[5-[(2-methyl-3-phenyl-phenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]methylamino]-3-oxidanyl-propanoic acid, Programmed cell death 1 ligand 1 著者 Cheng, Y, Xiao, Y.B. 登録日 2023-05-08 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J.Med.Chem., 66, 2023
8JF5	Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440 分子名称: 4-[5-[(3~{R})-3-azanylpyrrolidin-1-yl]carbonyl-2-[2-fluoranyl-4-(2-methyl-2-oxidanyl-propyl)phenyl]phenyl]-2-fluoranyl-benzenecarbonitrile, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Fukushima, H, Machida, T, Yamashita, S, Suzuki, T. 登録日 2023-05-17 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 TAS1440, a histone H3 competitive LSD1 inhibitor, activates both TGF-beta and notch signaling pathways via INSM1 dissociation in neuroendocrine small cell lung cancer To Be Published
8USW	CNQX-bound GluN1a-3A NMDA receptor 分子名称: 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, Glutamate receptor ionotropic, NMDA 1, ... 著者 Michalski, K, Furukawa, H. 登録日 2023-10-30 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (4.23 Å) 主引用文献 Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel. Sci Adv, 10, 2024
8USX	Glycine-bound GluN1a-3A NMDA receptor 分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 3A 著者 Michalski, K, Furukawa, H. 登録日 2023-10-30 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel. Sci Adv, 10, 2024
8UUE	Glycine-bound GluN1a-3A LBD heterotetramer (local refinement) 分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 3A 著者 Michalski, K, Furukawa, H. 登録日 2023-11-01 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.96 Å) 主引用文献 Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel. Sci Adv, 10, 2024
8EJ4	Cryo-EM structure of the active NLRP3 inflammasome disk 分子名称: MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 3, ... 著者 Hao, W, Le, X. 登録日 2022-09-16 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structures of the active NLRP3 inflammasome disc. Nature, 613, 2023
6AHF	CryoEM Reconstruction of Hsp104 N728A Hexamer 分子名称: Heat shock protein 104, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Zhang, X, Zhang, L, Zhang, S. 登録日 2018-08-17 公開日 2019-02-13 最終更新日 2019-04-10 実験手法 ELECTRON MICROSCOPY (6.78 Å) 主引用文献 Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity. J. Biol. Chem., 294, 2019
7SH2	Structure of the yeast Rad24-RFC loader bound to DNA and the open 9-1-1 clamp 分子名称: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... 著者 Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. 登録日 2021-10-07 公開日 2022-03-23 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nat.Struct.Mol.Biol., 29, 2022
7SGZ	Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp 分子名称: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... 著者 Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. 登録日 2021-10-07 公開日 2022-03-23 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nat.Struct.Mol.Biol., 29, 2022
6BVF	Cryo-EM Structure of Hepatitis B virus T=4 capsid in complex with the fluorescent allosteric modulator HAP-TAMRA 分子名称: Capsid protein, Heteroaryldihydropyrimidine tetramethylrodamine 著者 Schlicksup, C, Wang, J.C, Zlotnick, A. 登録日 2017-12-12 公開日 2018-02-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids. Elife, 7, 2018
2VKV	TetR (BD) variant L17G with reverse phenotype 分子名称: 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, ... 著者 Resch, M, Striegl, H, Henssler, E.M, Sevvana, M, Egerer-Sieber, C, Schiltz, E, Hillen, W, Muller, Y.A. 登録日 2008-01-02 公開日 2008-07-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 A Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr. Nucleic Acids Res., 36, 2008
6BVN	Cryo-EM Structure of Hepatitis B virus T=3 capsid in complex with the fluorescent allosteric modulator HAP-TAMRA 分子名称: Capsid protein, Heteroaryldihydropyrimidine tetramethylrodamine 著者 Schlicksup, C, Wang, J.C, Zlotnick, A. 登録日 2017-12-13 公開日 2018-02-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids. Elife, 7, 2018
3QGJ	1.3A Structure of alpha-Lytic Protease Bound to Ac-AlaAlaPro-Alanal 分子名称: 1,2-ETHANEDIOL, Ac-AlaAlaPro-Alanal peptide, Alpha-lytic protease, ... 著者 Everill, P, Meinke, G, Bohm, A, Bachovchin, W. 登録日 2011-01-24 公開日 2012-02-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Substrate Binding Defines Ser195 Position in the Catalytic Triad of Serine Proteases, Not His57 protonation To be Published

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