6ZC3
 
 | | Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling | | 分子名称: | 1,2-ETHANEDIOL, 5-fluoranyl-2-(methylsulfonylamino)benzoic acid, Dishevelled, ... | | 著者 | Roske, Y, Heinemann, U, Oschkinat, H. | | 登録日 | 2020-06-09 | | 公開日 | 2021-06-23 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
J.Magn.Reson., 2021
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5O1W
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8OMJ
 | | hKHK-C in complex with compound 28 | | 分子名称: | Ketohexokinase, SULFATE ION, [3-[[6-[(3~{a}~{R},6~{a}~{S})-2,3,3~{a},4,6,6~{a}-hexahydro-1~{H}-pyrrolo[3,4-c]pyrrol-5-yl]-3-cyano-4-(trifluoromethyl)pyridin-2-yl]amino]-4-methylsulfanyl-phenyl]methoxy-methyl-phosphinic acid | | 著者 | Pautsch, A, Ebenhoch, R. | | 登録日 | 2023-03-31 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.978 Å) | | 主引用文献 | Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability.
Bioorg.Med.Chem.Lett., 112, 2024
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6SE7
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9XY2
 | | One of a series of engineered variants of I-OnuI meganuclease targeting altered DNA target sequence | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Werther, R, Schwensen, J.S, Stoddard, B.L. | | 登録日 | 2025-08-25 | | 公開日 | 2025-09-10 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Prediction, modeling and design of protein-DNA recognition via computational and machine learning approaches:
accomplishments and remaining challenges
To Be Published
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6SIZ
 | | PaaK family AMP-ligase with ANP and substrate | | 分子名称: | 1,2-ETHANEDIOL, 3-HYDROXYANTHRANILIC ACID, AMP-dependent synthetase and ligase, ... | | 著者 | Naismith, J.H, Song, H. | | 登録日 | 2019-08-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.
Angew.Chem.Int.Ed.Engl., 59, 2020
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8CTJ
 | | Cryo-EM structure of TMEM87A | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Transmembrane protein 87A | | 著者 | Hoel, C.M, Zhang, L, Brohawn, S.G. | | 登録日 | 2022-05-15 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (4.74 Å) | | 主引用文献 | Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.
Elife, 11, 2022
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6XG1
 | | Class C beta-lactamase from Escherichia coli | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase | | 著者 | Chang, C, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-06-16 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | Class C beta-lactamase from Escherichia coli
To Be Published
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7QS0
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6XEB
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7MPS
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6PTM
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8RQI
 | | Structure of Rhizobium NopD with ubiquitin | | 分子名称: | NopD, Polyubiquitin-B, prop-2-en-1-amine | | 著者 | Reverter, D, Li, Y. | | 登録日 | 2024-01-18 | | 公開日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Broad-spectrum ubiquitin/ubiquitin-like deconjugation activity of the rhizobial effector NopD from Bradyrhizobium (sp. XS1150).
Commun Biol, 7, 2024
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8IYB
 | | Structure insight into substrate recognition and catalysis by feruloyl esterase from Aspergillus sydowii | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, ... | | 著者 | Phienluphon, A, Kondo, K, Mikami, B, Nagata, T, Katahira, M. | | 登録日 | 2023-04-04 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural insights into the molecular mechanisms of substrate recognition and hydrolysis by feruloyl esterase from Aspergillus sydowii.
Int.J.Biol.Macromol., 253, 2023
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8ZW0
 | | Cryo-EM strcuture of Prostaglandin D2 Receptor DP1 activated by PGD2 | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | 登録日 | 2024-06-12 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8IYC
 | | Structure insight into substrate recognition and catalysis by feruloyl esterase from Aspergillus sydowii | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | 著者 | Phienluphon, A, Kondo, K, Mikami, B, Nagata, T, Katahira, M. | | 登録日 | 2023-04-04 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural insights into the molecular mechanisms of substrate recognition and hydrolysis by feruloyl esterase from Aspergillus sydowii.
Int.J.Biol.Macromol., 253, 2023
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6ZK3
 | | Plant nucleoside hydrolase - ZmNRh2b in complex with ribose | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Morera, S, Vigouroux, A, Kopecny, D. | | 登録日 | 2020-06-29 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Plant nucleoside N-ribohydrolases: riboside binding and role in nitrogen storage mobilization.
Plant J., 2023
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6ZK4
 | | Plant nucleoside hydrolase - ZmNRh2b with a bound adenine | | 分子名称: | 1,2-ETHANEDIOL, ADENINE, CALCIUM ION, ... | | 著者 | Morera, S, Vigouroux, A, Kopecny, D. | | 登録日 | 2020-06-29 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Plant nucleoside N-ribohydrolases: riboside binding and role in nitrogen storage mobilization.
Plant J., 2023
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9NZ3
 | | SARS-CoV M protein dimer in complex with JNJ-9676 and FAb B | | 分子名称: | (6S,8R)-N-(3-cyanophenyl)-5-{4-[difluoro(phenyl)methyl]phenyl}-6-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-3-carboxamide, FAb B heavy chain, FAb B light chain, ... | | 著者 | Mann, M.K, Abeywickrema, P. | | 登録日 | 2025-03-31 | | 公開日 | 2025-10-29 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | SARS-CoV M protein dimer in complex with JNJ-9676 and FAb B
To Be Published
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6URY
 | | Crystal structure of ricin A chain in complex with inhibitor 9-oxo-4-fluorenecarboxamide | | 分子名称: | 1,2-ETHANEDIOL, 9-oxo-9H-fluorene-4-carboxamide, CHLORIDE ION, ... | | 著者 | Harijan, R.K, Li, X.P, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes.
Acs Infect Dis., 6, 2020
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8J5M
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8DPQ
 | | Beta-lactamase CTX-M-14 N170A | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase | | 著者 | Lu, S, Neetu, N, Palzkill, T. | | 登録日 | 2022-07-15 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance.
J.Biol.Chem., 299, 2023
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7N7G
 | | Crystal Structure of FosB from Enterococcus faecium with Fosfomycin | | 分子名称: | 1,2-ETHANEDIOL, FOSFOMYCIN, MANGANESE (II) ION, ... | | 著者 | Shay, M.R, Simmons, Z, Thompson, M.K. | | 登録日 | 2021-06-10 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and functional characterization of fosfomycin resistance conferred by FosB from Enterococcus faecium.
Protein Sci., 31, 2022
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6ZMN
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6IRC
 | | C-terminal domain of Drosophila phospholipase b NORPA, methylated | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | | 著者 | Ye, F, Li, J, Huang, Y, Liu, W, Zhang, M. | | 登録日 | 2018-11-12 | | 公開日 | 2019-01-02 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (3.538 Å) | | 主引用文献 | An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors.
Elife, 7, 2018
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