PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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5V43	Engineered human IgG Fc domain aglyco801 分子名称: Ig gamma-1 chain C region 著者 Yan, W, Marshall, N, Zhang, Y.J. 登録日 2017-03-08 公開日 2017-06-21 最終更新日 2017-09-27 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions. Nat. Immunol., 18, 2017
7QT0	Antibody FenAb136 - fentanyl complex 分子名称: 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid, Antibody heavy chain, Antibody light chain 著者 Zeelen, J.P, Straaten van, M, Stebbins, C.E. 登録日 2022-01-14 公開日 2023-05-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl. Cell Rep, 42, 2023
7QT4	Antibody FenAb709 - fentanyl complex 分子名称: 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid, Antibody heavy chain, Antibody light chain 著者 Zeelen, J.P, Straaten van, M, Stebbins, C.E. 登録日 2022-01-14 公開日 2023-05-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl. Cell Rep, 42, 2023
7QT3	Antibody FenAb609 - fentanyl complex 分子名称: Antibody heavy chain, Antibody light chain, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide 著者 Zeelen, J.P, Straaten van, M, Stebbins, C.E. 登録日 2022-01-14 公開日 2023-05-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl. Cell Rep, 42, 2023
6B52	Schistosoma haematobium (Blood Fluke) Sulfotransferase/Oxamniquine Complex, Y54F Mutant 分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol 著者 Taylor, A.B. 登録日 2017-09-27 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int.J.Parasitol., 2020
6B1C	Macrophage Migration Inhibitory Factor in complex with a Naphthyridinone Inhibitor (4a) 分子名称: 2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, Macrophage migration inhibitory factor, SULFATE ION 著者 Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. 登録日 2017-09-18 公開日 2018-01-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.163 Å) 主引用文献 Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6B2C	Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (4b) 分子名称: Macrophage migration inhibitory factor, SULFATE ION, {2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-8-oxo-1,7-naphthyridin-7(8H)-yl}acetic acid 著者 Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. 登録日 2017-09-19 公開日 2018-01-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6AU1	Structure of the PgaB (BpsB) glycoside hydrolase domain from Bordetella bronchiseptica 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Putative hemin storage protein, ... 著者 Little, D.J, Bamford, N.C, Howell, P.L. 登録日 2017-08-30 公開日 2018-04-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-beta (1,6)-N-acetylglucosamine and can disrupt bacterial biofilms. PLoS Pathog., 14, 2018
6B4Y	Schistosoma mansoni (Blood Fluke) Sulfotransferase/Oxamniquine Complex, F39Y Mutant 分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol 著者 Taylor, A.B. 登録日 2017-09-27 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int.J.Parasitol., 2020
6B50	Schistosoma mansoni (Blood Fluke) Sulfotransferase/Oxamniquine Complex, T157S Mutant 分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol 著者 Taylor, A.B. 登録日 2017-09-27 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int.J.Parasitol., 2020
6B1K	Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (3a) 分子名称: 2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, GLYCEROL, Macrophage migration inhibitory factor, ... 著者 Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. 登録日 2017-09-18 公開日 2018-01-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.17 Å) 主引用文献 Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6BCC	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide 分子名称: 6-ethoxy-1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Kovalevsky, A, McKenna, R, Aggarwal, M. 登録日 2017-10-20 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 NEUTRON DIFFRACTION (1.8 Å), X-RAY DIFFRACTION 主引用文献 "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure, 26, 2018
5VA0	Glucocorticoid Receptor DNA Binding Domain in complex with AP-1 response element from VCAM-1 Promoter 分子名称: DNA (5'-D(*CP*GP*GP*CP*TP*GP*AP*CP*TP*CP*AP*TP*CP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*GP*AP*TP*GP*AP*GP*TP*CP*AP*GP*CP*CP*G)-3'), Glucocorticoid receptor, ... 著者 Weikum, E.R, Ortlund, E.A. 登録日 2017-03-24 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.295 Å) 主引用文献 Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Res., 45, 2017
6BC9	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide 分子名称: (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 2, ZINC ION 著者 Kovalevsky, A, McKenna, R, Aggarwal, M. 登録日 2017-10-20 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 NEUTRON DIFFRACTION (1.8 Å), X-RAY DIFFRACTION 主引用文献 "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure, 26, 2018
6B4Z	Schistosoma mansoni (Blood Fluke) Sulfotransferase, T157S Mutant 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein 著者 Taylor, A.B. 登録日 2017-09-27 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int.J.Parasitol., 2020
6B54	Schistosoma haematobium (Blood Fluke) Sulfotransferase/Oxamniquine Complex, S166T Mutant 分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol 著者 Taylor, A.B. 登録日 2017-09-27 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int.J.Parasitol., 2020
5VA7	Glucocorticoid Receptor DNA Binding Domain - IL11 AP-1 recognition element Complex 分子名称: DNA (5'-D(*AP*GP*GP*GP*TP*GP*AP*GP*TP*CP*AP*GP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*CP*TP*GP*AP*CP*TP*CP*AP*CP*CP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Weikum, E.R, Ortlund, E.A. 登録日 2017-03-24 公開日 2017-08-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.153 Å) 主引用文献 Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Res., 45, 2017
6B51	Schistosoma haematobium (Blood Fluke) Sulfotransferase, Y54F Mutant 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase 著者 Taylor, A.B. 登録日 2017-09-27 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int.J.Parasitol., 2020
6BK3	Crystal structure of Os79 from O. sativa in complex with UDP and deoxynivalenol-3-glucoside (glucose moitey not resolved) 分子名称: (3alpha,7alpha)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, UDP-glycosyltransferase 79, URIDINE-5'-DIPHOSPHATE 著者 Wetterhorn, K, Gabardi, K, Rayment, I. 登録日 2017-11-07 公開日 2017-11-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Determinants and Expansion of Specificity in a Trichothecene UDP-Glucosyltransferase from Oryza sativa. Biochemistry, 56, 2017
5VN5	Crystal structure of LigY from Sphingobium sp. strain SYK-6 分子名称: 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl meta-cleavage compound hydrolase, CHLORIDE ION, ZINC ION 著者 Kuatsjah, E, Chan, A.C.K, Kobylarz, M.J, Murphy, M.E.P, Eltis, L.D. 登録日 2017-04-28 公開日 2017-09-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The bacterialmeta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the alpha / beta-hydrolase superfamily. J. Biol. Chem., 292, 2017
7S86	Crystal structure of hydrophobin SC16, C2221 分子名称: 1,2-ETHANEDIOL, Hydrophobin, SODIUM ION 著者 Vergunst, K.L, Langelaan, D.N. 登録日 2021-09-17 公開日 2021-12-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The N-terminal tail of the hydrophobin SC16 is not required for rodlet formation Sci Rep, 12, 2022
7SAQ	Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B 著者 Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. 登録日 2021-09-23 公開日 2022-03-09 最終更新日 2022-05-25 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
7SAS	Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B 著者 Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. 登録日 2021-09-23 公開日 2022-03-09 最終更新日 2022-05-25 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
7SAR	Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B 著者 Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. 登録日 2021-09-23 公開日 2022-03-09 最終更新日 2022-05-25 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
6C8T	The structure of MppP soaked with the substrate L-Arg 分子名称: (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine, CHLORIDE ION, PLP-Dependent L-Arginine Hydroxylase MppP 著者 Han, L, Silvaggi, N.R. 登録日 2018-01-25 公開日 2018-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase. Biochemistry, 57, 2018

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