4WD5
 
 | |
7OFI
 | | Ligand complex of RORg LBD | | 分子名称: | (2~{R})-2-(4-ethylsulfonylphenyl)-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-~{N}'-methyl-butanediamide, DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, ... | | 著者 | Xue, Y, Aagaard, A, Narjes, F. | | 登録日 | 2021-05-05 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | | 主引用文献 | AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
J.Med.Chem., 64, 2021
|
|
6NBO
 | |
4WAN
 | | Crystal structure of Msl5 protein in complex with RNA at 1.8 A | | 分子名称: | ACETATE ION, Branchpoint-bridging protein, GLYCEROL, ... | | 著者 | Jacewicz, A, Smith, P, Chico, L, Schwer, B, Shuman, S. | | 登録日 | 2014-08-29 | | 公開日 | 2014-12-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs.
Rna, 21, 2015
|
|
8Y2R
 | | NMR Solution Structure of the 2:1 Coptisine-ATF4-G4 Complex | | 分子名称: | 6,7-dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquino[3,2-a]isoquinolin-5-ium, DNA (5'-D(*TP*AP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*AP*GP*GP*GP*AP*GP*C*(LIG)*(LIG))-3') | | 著者 | Xiao, C.M, Li, Y.P, Liu, Y.S, Dong, R.F, He, X.Y, Lin, Q, Zang, X, Wang, K.B, Xia, Y.Z, Kong, L.Y. | | 登録日 | 2024-01-27 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-06-18 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G-quadruplex.
Adv Sci, 11, 2024
|
|
7NYP
 | | monomeric acetyl-CoA synthase in closed conformation | | 分子名称: | 2-[3,8,8,12,12-pentakis(2-hydroxy-2-oxoethyl)-2,7,11-tris(oxidanylidene)-1,4,6,9,10,13-hexaoxa-5$l^{6}-titanaspiro[4.4^{5}.4^{5}]tridecan-3-yl]ethanoic acid, CO-methylating acetyl-CoA synthase, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Kreibich, J, Jeoung, J.H, Dobbek, H. | | 登録日 | 2021-03-23 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Ligand binding at the Ni,Ni-[4Fe-4S] cluster of acetyl-CoA synthase
To Be Published
|
|
7NZ5
 | | monomeric acetyl-CoA synthase with Zn at the proximal position of cluster A | | 分子名称: | (R,R)-2,3-BUTANEDIOL, 2-[3,8,8,12,12-pentakis(2-hydroxy-2-oxoethyl)-2,7,11-tris(oxidanylidene)-1,4,6,9,10,13-hexaoxa-5$l^{6}-titanaspiro[4.4^{5}.4^{5}]tridecan-3-yl]ethanoic acid, CITRIC ACID, ... | | 著者 | Kreibich, J, Jeoung, J.H, Dobbek, H. | | 登録日 | 2021-03-23 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Ligand binding at the Ni,Ni-[4Fe-4S] cluster of acetyl-CoA synthase
To Be Published
|
|
4US0
 | | The crystal structure of H-Ras and SOS in complex with ligands | | 分子名称: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, GTPase HRas, Son of sevenless homolog 1 | | 著者 | Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. | | 登録日 | 2014-07-02 | | 公開日 | 2015-03-04 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
|
|
6NSJ
 | | CryoEM structure of Helicobacter pylori urea channel in closed state | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel | | 著者 | Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H. | | 登録日 | 2019-01-24 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM.
Sci Adv, 5, 2019
|
|
7SUA
 | | Crystal Structure of the Hypothetical Protein (ACX60_00475) from Acinetobacter baumannii | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DUF4175 domain-containing protein | | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Kiryukhina, O, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2021-11-16 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal Structure of the Hypothetical Protein (ACX60_00475) from Acinetobacter baumannii
To be Published
|
|
8VS7
 | | Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 2C1 Fab | | 分子名称: | 1,2-ETHANEDIOL, 2C1 Heavy Chain, 2C1 Light Chain, ... | | 著者 | Kher, G, Homad, L.J, McGuire, A.T, Pancera, M. | | 登録日 | 2024-01-23 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | A novel RSV vaccine candidate derived from anti-idiotypic antibodies targets putative neutralizing B-cells in bulk PBMCs
To Be Published
|
|
6NSK
 | | CryoEM structure of Helicobacter pylori urea channel in open state. | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel | | 著者 | Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H. | | 登録日 | 2019-01-24 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM.
Sci Adv, 5, 2019
|
|
7OK8
 | |
6NIC
 | | Crystal Structure of Medicago truncatula Agmatine Iminohydrolase (Deiminase) in Complex with 6-aminohexanamide | | 分子名称: | 1,2-ETHANEDIOL, 6-aminohexanamide, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sekula, B, Dauter, Z. | | 登録日 | 2018-12-27 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Study of Agmatine Iminohydrolase FromMedicago truncatula, the Second Enzyme of the Agmatine Route of Putrescine Biosynthesis in Plants.
Front Plant Sci, 10, 2019
|
|
4WAG
 | |
7NY9
 | |
6NYV
 | | Structure of spastin AAA domain in complex with a quinazoline-based inhibitor | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, N-(3-tert-butyl-1H-pyrazol-5-yl)-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine, SULFATE ION, ... | | 著者 | Pisa, R, Cupido, T, Kapoor, T.M. | | 登録日 | 2019-02-12 | | 公開日 | 2019-03-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.425 Å) | | 主引用文献 | Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein.
J. Am. Chem. Soc., 141, 2019
|
|
7NWB
 | |
7NWA
 | |
7NXN
 | |
8EHB
 | |
7OP2
 | | Chadox1/ Chimpanzee adenovirus Y25 fiber knob protein | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | 著者 | Rizkallah, P.J, Baker, A.T, Parker, A.L, Teijeira Crespo, A, Lipka-Lloyd, M. | | 登録日 | 2021-05-28 | | 公開日 | 2021-06-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.
Sci Adv, 7, 2021
|
|
8H0M
 | | Crystal structure of VioD | | 分子名称: | (2S)-2-ethylhexan-1-ol, FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, ... | | 著者 | Xu, M, Ran, T, Wang, W. | | 登録日 | 2022-09-29 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | | 主引用文献 | Structural basis for substrate binding and catalytic mechanism of the key enzyme VioD in the violacein synthesis pathway.
Proteins, 91, 2023
|
|
4WHK
 | | A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1 | | 分子名称: | C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, Serine/threonine-protein kinase PLK1 | | 著者 | Bang, J.K, Han, Y.H, Ahn, M.J, Lee, K.S. | | 登録日 | 2014-09-23 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
|
|
7OO4
 | |
