5ZZN
| Crystal structure of photosystem II from an SQDG-deficient mutant of Thermosynechococcus elongatus | 分子名称: | (3R)-beta,beta-caroten-3-ol, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | 著者 | Nakajima, Y, Umena, Y, Nagao, R, Endo, K, Kobayashi, K, Akita, F, Suga, M, Wada, H, Noguchi, T, Shen, J.R. | 登録日 | 2018-06-03 | 公開日 | 2018-08-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Thylakoid membrane lipid sulfoquinovosyl-diacylglycerol (SQDG) is required for full functioning of photosystem II inThermosynechococcus elongatus. J. Biol. Chem., 293, 2018
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7CW4
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4Q20
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6A2L
| Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT1, NADPH, and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | 著者 | Chitnumsub, P, Jaruwat, A, Tarnchampoo, B, Yuthavong, Y. | 登録日 | 2018-06-12 | 公開日 | 2019-04-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett, 9, 2018
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3ICZ
| Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with 1-(2,2-Bis-phosphono-ethyl)-3-butyl-pyridinium and isopentenyl pyrophosphate | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 3-[(1E)-but-1-en-1-yl]-1-(2,2-diphosphonoethyl)pyridinium, Farnesyl pyrophosphate synthase, ... | 著者 | Amzel, L.M, Huang, C.H, Gabelli, S.B, Oldfield, E. | 登録日 | 2009-07-19 | 公開日 | 2010-02-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins, 78, 2010
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6PTY
| Soluble model of human CuA (Tt3Lh) | 分子名称: | Cytochrome c oxidase subunit 2, DINUCLEAR COPPER ION, GLYCEROL, ... | 著者 | Giannini, E, Lisa, M.N, Morgada, M.N, Alzari, P.M, Vila, A.J. | 登録日 | 2019-07-16 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Unexpected electron spin density on the axial methionine ligand in CuAsuggests its involvement in electron pathways. Chem.Commun.(Camb.), 56, 2020
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5JPH
| Structure of a GNAT acetyltransferase SACOL1063 from Staphylococcus aureus in complex with CoA | 分子名称: | Acetyltransferase SACOL1063, CHLORIDE ION, COENZYME A | 著者 | Majorek, K.A, Osinski, T, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2016-05-03 | 公開日 | 2016-06-29 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria. Biochim.Biophys.Acta, 1865, 2016
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4Q9O
| Crystal structure of Upps + inhibitor | 分子名称: | 3-(2-chlorophenyl)-5-methyl-N-[4-(propan-2-yl)phenyl]-1,2-oxazole-4-carboxamide, Isoprenyl transferase, SULFATE ION | 著者 | Liu, S, Qiu, X. | 登録日 | 2014-05-01 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase. Protein Sci., 24, 2015
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7CM8
| High resolution crystal structure of M92A mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae | 分子名称: | Cysteine synthase, GLYCEROL, SODIUM ION | 著者 | Kaushik, A, Rahisuddin, R, Saini, N, Kumaran, S. | 登録日 | 2020-07-25 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular mechanism of selective substrate engagement and inhibitor disengagement of cysteine synthase. J.Biol.Chem., 296, 2020
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6PW9
| Cryo-EM structure of human NatE/HYPK complex | 分子名称: | ACETYL COENZYME *A, Huntingtin-interacting protein K, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Deng, S, Marmorstein, R. | 登録日 | 2019-07-22 | 公開日 | 2020-02-19 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK. Nat Commun, 11, 2020
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5F6Q
| Crystal Structure of Metallothiol Transferase from Bacillus anthracis str. Ames | 分子名称: | CHLORIDE ION, GLYCEROL, Metallothiol transferase FosB 2, ... | 著者 | Maltseva, N, Kim, Y, Osipiuk, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2015-12-06 | 公開日 | 2015-12-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Crystal Structure of Metallothiol Transferase from Bacillus anthracis str. Ames To Be Published
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5JTF
| Crystal structure of ArsN N-acetyltransferase from Pseudomonas putida KT2440 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Putative Phosphinothricin N-acetyltransferase | 著者 | Venkadesh, S, Dheeman, D.S, Kandavelu, P, Rosen, B.P. | 登録日 | 2016-05-09 | 公開日 | 2017-05-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.156 Å) | 主引用文献 | Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic. Commun Biol, 2, 2019
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3IJZ
| Lactobacillus casei Thymidylate Synthase ternary complex with dUMP and Pthalimidic derivative 15C | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(4-acetylphenyl)-4-methyl-1H-isoindole-1,3(2H)-dione, Thymidylate synthase | 著者 | Pozzi, C, Cancian, L, Leone, R, Luciani, R, Ferrari, S, Mangani, S, Costi, M.P. | 登録日 | 2009-08-05 | 公開日 | 2010-08-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54, 2011
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4QAV
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5F38
| X-ray crystal structure of a thiolase from Escherichia coli at 1.8 A resolution | 分子名称: | 1,2-ETHANEDIOL, Acetyl-CoA acetyltransferase, COENZYME A, ... | 著者 | Ithayaraja, M, Neelanjana, J, Wierenga, R, Savithri, H.S, Murthy, M.R.N. | 登録日 | 2015-12-02 | 公開日 | 2016-07-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of a thiolase from Escherichia coli at 1.8 angstrom resolution. Acta Crystallogr.,Sect.F, 72, 2016
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4QC6
| Crystal structure of aminoglycoside 6'-acetyltransferase-Ie | 分子名称: | (3R,5S,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3,5-diphosphaheptadecane-17-sulfinic acid 3,5-dioxide (non-preferred name), Bifunctional AAC/APH, FORMIC ACID, ... | 著者 | Smith, C.A, Toth, M, Weiss, T.M, Frase, H, Vakulenko, S.B. | 登録日 | 2014-05-09 | 公開日 | 2014-10-22 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis. Acta Crystallogr.,Sect.D, 70, 2014
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5F47
| Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with trehalose | 分子名称: | CALCIUM ION, CHLORIDE ION, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, ... | 著者 | Xu, Z, Skarina, T, Wawrzak, Z, Stogios, P.J, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2015-12-03 | 公開日 | 2015-12-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.497 Å) | 主引用文献 | Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes. ACS Infect Dis, 3, 2017
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7CCA
| Crystal structure of White Spot Syndrome Virus Thymidylate Synthase - ternary complex with Methotrexate and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, Thymidylate Synthase | 著者 | Panchal, N.V, Kumar, S, Shaikh, N, Vasudevan, D. | 登録日 | 2020-06-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure analysis of thymidylate synthase from white spot syndrome virus reveals WSSV-specific structural elements. Int.J.Biol.Macromol., 167, 2021
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6AHI
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4PVY
| Crystal structure of human FPPS in complex with [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid) | 分子名称: | Farnesyl pyrophosphate synthase, GLYCEROL, MAGNESIUM ION, ... | 著者 | Rodionov, D, Park, J, De Schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2014-03-18 | 公開日 | 2015-04-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE, 12, 2017
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6AIF
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4CW4
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6AG8
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6AJN
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3IK0
| Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 7C1 | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenecarboximidamide, Thymidylate synthase | 著者 | Pozzi, C, Cancian, L, Leone, R, Luciani, R, Ferrari, S, Mangani, S, Costi, M.P. | 登録日 | 2009-08-05 | 公開日 | 2010-08-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54, 2011
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