PDB: 7816 件ウェブページステータス検索Chemie searchBIRD

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6V0V	Cryo-EM structure of mouse WT RAG1/2 NFC complex (DNA0) 分子名称: CALCIUM ION, DNA (30-MER), V(D)J recombination-activating protein 1, ... 著者 Chen, X, Yang, W, Gellert, M. 登録日 2019-11-19 公開日 2020-01-29 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
6VH7	Doublet Tau Fibril from Corticobasal Degeneration Human Brain Tissue 分子名称: Microtubule-associated protein tau 著者 Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. 登録日 2020-01-09 公開日 2020-03-04 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell, 180, 2020
8ELZ	HRAS R97M Crystal Form 1 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... 著者 Johnson, C.W, Mattos, C. 登録日 2022-09-26 公開日 2023-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.961 Å) 主引用文献 Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
8ELS	HRAS R97A Crystal Form 1 R-state 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Davis, D, Johnson, C.W, Mattos, C. 登録日 2022-09-26 公開日 2023-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.267 Å) 主引用文献 Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
8F04	Structure of elevenin-Vc1 from venom of the Australian cone snail Conus victoriae 分子名称: Elevenin-Vc1 著者 Krishnarjuna, B, Sunanda, P, Norton, R.S. 登録日 2022-11-01 公開日 2023-09-13 実験手法 SOLUTION NMR 主引用文献 Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae : A Structural Analogue of alpha-Conotoxins. Mar Drugs, 21, 2023
6DRK	Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, Apo state 分子名称: Transient receptor potential cation channel, subfamily M, member 2 著者 Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W. 登録日 2018-06-12 公開日 2018-09-19 最終更新日 2018-10-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature, 562, 2018
8D8I	Crystal structure of Reverb alpha in complex with synthetic agonist 分子名称: (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine, Nuclear receptor corepressor 1, Nuclear receptor subfamily 1 group D member 1 著者 Ronin, C, Ciesielski, F, Hegazy, L, Burris, P.T. 登録日 2022-06-08 公開日 2022-12-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.504 Å) 主引用文献 Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 13, 2022
6UQD	Co-complex of S. pyogenes 10782 streptopain bound with a SuFEx-based optimized small molecule inhibitor 分子名称: Streptopain, benzyl [(1S)-2-(3-{[(4-carbamoylpiperidin-1-yl)(fluoro)oxo-lambda~6~-sulfanylidene]amino}phenyl)-1-cyanoethyl]carbamate 著者 Wolan, D.W, Woehl, J.L, Kitamura, S. 登録日 2019-10-18 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry. J.Am.Chem.Soc., 142, 2020
6DRJ	Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel, ... 著者 Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W. 登録日 2018-06-12 公開日 2018-09-19 最終更新日 2018-10-10 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature, 562, 2018
6S9K	Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS 分子名称: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, Caspase-2 著者 Alblova, M, Obsil, T, Obsilova, V. 登録日 2019-07-15 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
6SHI	Human kallikrein 7 with aromatic coumarinic ester compound 2 covalently bound to H57 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-methyl-2-oxidanylidene-chromene-3-carboxylic acid, Kallikrein-7, ... 著者 Hanke, S, Straeter, N. 登録日 2019-08-06 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7. J.Med.Chem., 63, 2020
8EK5	Engineered scFv 10LH bound to PHOX2B/HLA-A24:02 分子名称: 10LH single chain fragment variable (scFv), Beta-2-microglobulin, GLYCEROL, ... 著者 Garfinkle, S.E, Florio, T.J, Sgourakis, N.G. 登録日 2022-09-20 公開日 2023-12-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
6SAD	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164 分子名称: 14-3-3 protein gamma, Caspase-2 著者 Kalabova, D, Obsil, T, Obsilova, V. 登録日 2019-07-16 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.753 Å) 主引用文献 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
8EZB	NHEJ Long-range complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... 著者 Chen, S, He, Y. 登録日 2022-10-31 公開日 2023-06-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (8.9 Å) 主引用文献 Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
8EZA	NHEJ Long-range complex with PAXX 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... 著者 Chen, S, He, Y. 登録日 2022-10-31 公開日 2023-06-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.39 Å) 主引用文献 Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
6E65	Crystal structure of malaria transmission-blocking antibody TB31F 分子名称: TB31F Fab heavy chain, TB31F Fab light chain 著者 Kundu, P, Semesi, A, Julien, J.P. 登録日 2018-07-23 公開日 2018-11-28 最終更新日 2018-12-05 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45. Nat Commun, 9, 2018
6E6T	Dieckmann cyclase, NcmC, bound to cerulenin 分子名称: (4S,5R)-4,5-dihydroxy-5-[(3E,6E)-octa-3,6-dien-1-yl]pyrrolidin-2-one, NcmC, SULFATE ION 著者 Cogan, D.P, Nair, S.K. 登録日 2018-07-25 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation. Acs Chem.Biol., 2020
6VHL	Paired Helical Filament from Alzheimer's Disease Human Brain Tissue 分子名称: GLYCINE, Microtubule-associated protein tau 著者 Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. 登録日 2020-01-10 公開日 2020-03-04 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell, 180, 2020
6V6T	Solution structure of delta-theraphotoxin-Hm1b from Heteroscodra maculata 分子名称: Delta-theraphotoxin-Hm1b 著者 Chin, Y.K.Y, Chow, C.Y, King, G.F. 登録日 2019-12-05 公開日 2020-05-13 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 A selective Na V 1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem Pharmacol, 181, 2020
8FPT	STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE 分子名称: Alpha-synuclein 著者 Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. 登録日 2023-01-05 公開日 2023-02-22 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. Biorxiv, 2023
6VB9	Covalent adduct of cis-2,3-epoxysuccinic acid with Isocitrate Lyase-1 from Mycobacterium tuberculosis 分子名称: ACETIC ACID, DI(HYDROXYETHYL)ETHER, Isocitrate lyase, ... 著者 Krieger, I.V, Pham, T.V, Meek, T.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2019-12-18 公開日 2020-12-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.881 Å) 主引用文献 Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis -2,3-Epoxy-Succinic Acid. Acs Chem.Biol., 16, 2021
8FE9	Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b 分子名称: Activated CDC42 kinase 1, N-[(1S)-1-benzyl-2-[(6-chloro-2-oxo-1H-quinolin-4-yl)methylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carbo 著者 Paung, Y, Kan, Y, Seeliger, M.S, Miller, W.T. 登録日 2022-12-06 公開日 2023-03-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry, 62, 2023
8FO6	Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. 分子名称: CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase, ... 著者 Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. 登録日 2022-12-29 公開日 2023-05-03 実験手法 X-RAY DIFFRACTION (2.553 Å) 主引用文献 ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
6VI3	Straight Filament from Alzheimer's Disease Human Brain Tissue 分子名称: GLYCINE, Microtubule-associated protein tau 著者 Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. 登録日 2020-01-11 公開日 2020-04-15 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains Cell, 180, 2020
3D29	Proteasome Inhibition by Fellutamide B 分子名称: (3R)-3-HYDROXYDODECANOIC ACID, Fellutamide B, PRE10 isoform 1, ... 著者 Groll, M, Hines, J, Fahnestock, M, Crews, M.C. 登録日 2008-05-07 公開日 2008-06-10 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis Chem.Biol., 15, 2008

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