7K4A
 
 | | Cryo-EM structure of human TRPV6 in the open state | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | | 登録日 | 2020-09-15 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6.
Sci Adv, 6, 2020
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5P9K
 | | CRYSTAL STRUCTURE OF BTK with CNX 774 | | 分子名称: | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{N}-methyl-pyridine-2-carboxamide, Tyrosine-protein kinase BTK | | 著者 | Gardberg, A.S. | | 登録日 | 2016-09-20 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol. Pharmacol., 91, 2017
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3LG8
 | | Crystal structure of the C-terminal part of subunit E (E101-206) from Methanocaldococcus jannaschii of A1AO ATP synthase | | 分子名称: | A-type ATP synthase subunit E | | 著者 | Balakrishna, A.M, Manimekalai, M.S.S, Hunke, C, Gayen, S, Jeyakanthan, J, Gruber, G. | | 登録日 | 2010-01-19 | | 公開日 | 2010-07-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Crystal and solution structure of the C-terminal part of the Methanocaldococcus jannaschii A1AO ATP synthase subunit E revealed by X-ray diffraction and small-angle X-ray scattering
J.Bioenerg.Biomembr., 42, 2010
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2HVD
 | | Human nucleoside diphosphate kinase A complexed with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A | | 著者 | Giraud, M.-F, Georgescauld, F, Lascu, I, Dautant, A. | | 登録日 | 2006-07-28 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal Structures of S120G Mutant and Wild Type of Human Nucleoside Diphosphate Kinase A in Complex with ADP
J.Bioenerg.Biomembr., 38, 2006
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2HVE
 | | S120G mutant of human nucleoside diphosphate kinase A complexed with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A | | 著者 | Giraud, M.-F, Georgescauld, F, Lascu, I, Dautant, A. | | 登録日 | 2006-07-28 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Crystal Structures of S120G Mutant and Wild Type of Human Nucleoside Diphosphate Kinase A in Complex with ADP
J.Bioenerg.Biomembr., 38, 2006
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8ZYO
 | | Cryo-EM Structure of astemizole-bound hERG Channel | | 分子名称: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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8ZYN
 | | Cryo-EM Structure of inhibitor-free hERG Channel | | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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8ZYQ
 | | Cryo-EM Structure of pimozide-bound hERG Channel | | 分子名称: | 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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8ZYP
 | | Cryo-EM Structure of E-4031-bound hERG Channel | | 分子名称: | Potassium voltage-gated channel subfamily H member 2, ~{N}-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidin-4-yl]carbonylphenyl]methanesulfonamide | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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9F40
 | | Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with ergosterol bound | | 分子名称: | ACETONITRILE, DI(HYDROXYETHYL)ETHER, ERGOSTEROL, ... | | 著者 | Nel, L, Olesen, E, Frain, K.M, Pedersen, B.P. | | 登録日 | 2024-04-26 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C 1-related protein
To Be Published
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6VGD
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6VG2
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6VG8
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8C80
 | | Cryo-EM structure of the yeast SPT-Orm1-Monomer complex | | 分子名称: | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ERGOSTEROL, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, ... | | 著者 | Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F. | | 登録日 | 2023-01-18 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of the ceramide-bound SPOTS complex.
Nat Commun, 14, 2023
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8C81
 | | Cryo-EM structure of the yeast SPT-Orm1-Sac1 complex | | 分子名称: | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ERGOSTEROL, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, ... | | 著者 | Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F. | | 登録日 | 2023-01-18 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of the ceramide-bound SPOTS complex.
Nat Commun, 14, 2023
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5VA1
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5VA2
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5VA3
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6R4N
 | | Crystal structure of S. cerevisia Niemann-Pick type C protein NPC2 with ergosterol bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ERGOSTEROL, ... | | 著者 | Winkler, M.B.L, Kidmose, R.T, Pedersen, B.P. | | 登録日 | 2019-03-22 | | 公開日 | 2019-09-25 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Cell, 179, 2019
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6QV2
 | | Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2 | | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | | 登録日 | 2019-03-01 | | 公開日 | 2019-05-29 | | 最終更新日 | 2019-06-05 | | 実験手法 | X-RAY DIFFRACTION (4.23 Å) | | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
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6QV1
 | | Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM1 | | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | | 登録日 | 2019-03-01 | | 公開日 | 2019-05-29 | | 最終更新日 | 2019-06-05 | | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
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6QV0
 | | Structure of ATP-bound outward-facing TM287/288 in complex with sybody Sb_TM35 | | 分子名称: | ABC transporter, ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | | 登録日 | 2019-03-01 | | 公開日 | 2019-05-29 | | 最終更新日 | 2019-06-05 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
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6QUZ
 | | Structure of ATPgS-bound outward-facing TM287/288 in complex with sybody Sb_TM35 | | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | | 登録日 | 2019-03-01 | | 公開日 | 2019-05-29 | | 最終更新日 | 2019-06-05 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
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4X8O
 | | Crystal structure of E. coli Adenylate kinase Y171W mutant in complex with inhibitor Ap5a | | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. | | 登録日 | 2014-12-10 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for catalytically restrictive dynamics of a high-energy enzyme state.
Nat Commun, 6, 2015
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4X8H
 | | Crystal structure of E. coli Adenylate kinase P177A mutant | | 分子名称: | Adenylate kinase | | 著者 | Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. | | 登録日 | 2014-12-10 | | 公開日 | 2015-07-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for catalytically restrictive dynamics of a high-energy enzyme state.
Nat Commun, 6, 2015
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