6XRJ
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6P62
| HIV Env BG505 NFL TD+ in complex with antibody E70 fragment antigen binding | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env BG505 NFL TD+, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2019-05-31 | 公開日 | 2019-11-20 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability. Immunity, 51, 2019
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7ONJ
| Mechanosensitive channel MscS solubilized with LMNG in open conformation | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DODECYL-BETA-D-MALTOSIDE, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Rasmussen, T, Flegler, V.J, Boettcher, B. | 登録日 | 2021-05-25 | 公開日 | 2021-09-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Mechanosensitive channel gating by delipidation. Proc.Natl.Acad.Sci.USA, 118, 2021
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6NF5
| BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG18-like precursor HMP1 fragment antigen binding heavy chain, ... | 著者 | Ozorowski, G, Torres, J.L, Steichen, J.M, Schief, W.R, Ward, A.B. | 登録日 | 2018-12-18 | 公開日 | 2019-11-06 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science, 366, 2019
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6XQ7
| Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 5 | 分子名称: | 5-bromo-3-methyl-1H-indole-2-carboxylic acid, ACETATE ION, Advanced glycosylation end product-specific receptor, ... | 著者 | Salay, L.E, Kozlyuk, N, Gilston, B.A, Gogliotti, R.D, Christov, P.P, Kim, K, Ovee, M, Waterson, A.G, Chazin, W.J. | 登録日 | 2020-07-09 | 公開日 | 2021-07-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors. Proteins, 89, 2021
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5Y6E
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5YQZ
| Structure of the glucagon receptor in complex with a glucagon analogue | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glucagon analogue, ... | 著者 | Zhang, H, Qiao, A, Yang, L, VAN EPS, N, Frederiksen, K, Yang, D, Dai, A, Cai, X, Zhang, H, Yi, C, Can, C, He, L, Yang, H, Lau, J, Ernst, O, Hanson, M, Stevens, R, Wang, M, Seedtz-Runge, S, Jiang, H, Zhao, Q, Wu, B. | 登録日 | 2017-11-08 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the glucagon receptor in complex with a glucagon analogue. Nature, 553, 2018
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7ODU
| Natural killer cell receptor NKR-P1B from Rattus norvegicus in complex with its cognate ligand Clr-11 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D11, ... | 著者 | Skalova, T, Blaha, J, Kalouskova, B, Skorepa, O, Vanek, O, Dohnalek, J. | 登録日 | 2021-04-30 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Natural killer cell receptor NKR-P1B from Rattus norvegicus in complex with its cognate ligand Clr-11 To Be Published
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6NIG
| Crystal structure of the human TLR2-Diprovocim complex | 分子名称: | (3S,4S,3'S,4'S)-1,1'-(1,4-phenylenedicarbonyl)bis{N~3~,N~4~-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxami de}, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, H, Beutler, B.A, Tomchick, D.R, Su, L. | 登録日 | 2018-12-27 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim. J. Med. Chem., 62, 2019
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6NFC
| BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG18-like precursor HMP42 fragment antigen binding heavy chain, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2018-12-19 | 公開日 | 2019-11-06 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science, 366, 2019
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6NE5
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7OOA
| Mechanosensitive channel MscS solubilized with LMNG in open conformation with added lipid | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DODECYL-BETA-D-MALTOSIDE, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Rasmussen, T, Flegler, V.J, Boettcher, B. | 登録日 | 2021-05-27 | 公開日 | 2021-09-01 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Mechanosensitive channel gating by delipidation. Proc.Natl.Acad.Sci.USA, 118, 2021
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8BNA
| BINDING OF HOECHST 33258 TO THE MINOR GROOVE OF B-DNA | 分子名称: | 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION | 著者 | Pjura, P.E, Grzeskowiak, K, Dickerson, R.E. | 登録日 | 1986-08-29 | 公開日 | 1987-01-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Binding of Hoechst 33258 to the minor groove of B-DNA. J.Mol.Biol., 197, 1987
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6WU8
| Structure of human SHP2 in complex with inhibitor IACS-13909 | 分子名称: | 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Leonard, P.G, Joseph, S, Rodenberger, A. | 登録日 | 2020-05-04 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res., 80, 2020
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6XOX
| cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 | 分子名称: | 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Glucagon-like peptide 1 receptor, ... | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | 登録日 | 2020-07-07 | 公開日 | 2020-11-18 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist. Proc.Natl.Acad.Sci.USA, 117, 2020
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5Y6D
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6X0O
| Single-Particle Cryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, CALCIUM ION, Integral membrane indolylacetylinositol arabinosyltransferase EmbB | 著者 | Tan, Y.Z, Rodrigues, J, Keener, J.E, Zheng, R.B, Brunton, R, Kloss, B, Giacometti, S.I, Rosario, A.L, Zhang, L, Niederweis, M, Clarke, O.B, Lowary, T.L, Marty, M.T, Archer, M, Potter, C.S, Carragher, B, Mancia, F. | 登録日 | 2020-05-17 | 公開日 | 2020-06-10 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis. Nat Commun, 11, 2020
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6Y8O
| Mycobacterium smegmatis GyrB 22kDa ATPase sub-domain in complex with novobiocin | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DNA gyrase subunit B, ... | 著者 | Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A. | 登録日 | 2020-03-05 | 公開日 | 2020-08-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase. J.Antimicrob.Chemother., 75, 2020
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8C63
| Crystal structure of arsenoplatin-1/B-DNA adduct obtained upon 4 h of soaking | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, PLATINUM (II) ION, ... | 著者 | Troisi, R, Tito, G, Ferraro, G, Sica, F, Merlino, A. | 登録日 | 2023-01-11 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer. Dalton Trans, 53, 2024
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8C64
| Crystal structure of arsenoplatin-1/B-DNA adduct obtained upon 48 h of soaking | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), PLATINUM (II) ION, arsenoplatin-1 | 著者 | Troisi, R, Tito, G, Ferraro, G, Sica, F, Merlino, A. | 登録日 | 2023-01-11 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer. Dalton Trans, 53, 2024
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7NWK
| Crystal structure of CDK9-Cyclin T1 bound by compound 6 | 分子名称: | Cyclin-T1, Cyclin-dependent kinase 9, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide | 著者 | Collie, G.W, Ferguson, A.D. | 登録日 | 2021-03-16 | 公開日 | 2021-10-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J.Med.Chem., 64, 2021
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5XF3
| Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,R-configuration) | 分子名称: | (1R,2R)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ... | 著者 | Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A. | 登録日 | 2017-04-07 | 公開日 | 2017-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation Nat Commun, 8, 2017
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5XF5
| Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,S-configuration) | 分子名称: | (1S,2R)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ... | 著者 | Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A. | 登録日 | 2017-04-07 | 公開日 | 2017-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation Nat Commun, 8, 2017
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6WS6
| Structural and functional analysis of a potent sarbecovirus neutralizing antibody | 分子名称: | O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), S309 antigen-binding (Fab) fragment, heavy chain, ... | 著者 | Pinto, D, Park, Y.J, Beltramello, M, Walls, A.C, Tortorici, M.A, Bianchi, S, Jaconi, S, Culap, K, Zatta, F, Marco, A.D, Peter, A, Guarino, B, Spreafico, R, Cameroni, E, Case, J.B, Chen, R.E, Havenar-Daughton, C, Snell, G, Telenti, A, Virgin, H.W, Lanzavecchia, A, Diamond, M.S, Fink, K, Veesler, D, Corti, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2020-04-30 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature, 583, 2020
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5XHE
| Crystal structure analysis of the second bromodomain of BRD2 covalently linked to b-mercaptoethanol | 分子名称: | Bromodomain-containing protein 2, GLYCEROL, TRIETHYLENE GLYCOL | 著者 | Padmanabhan, B, Mathur, S, Tripathi, S.K, Deshmukh, P. | 登録日 | 2017-04-20 | 公開日 | 2017-09-06 | 最終更新日 | 2018-08-01 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Insights into the crystal structure of BRD2-BD2 - phenanthridinone complex and theoretical studies on phenanthridinone analogs. J. Biomol. Struct. Dyn., 36, 2018
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