PDB: 1008 件ウェブページステータス検索Chemie searchBIRD

---

2GBG	rat DPP-IV with alkynyl cyanopyrrolidine #2 分子名称: (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE, Dipeptidyl peptidase 4, SULFATE ION 著者 Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. 登録日 2006-03-10 公開日 2006-07-04 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors. Biochemistry, 45, 2006
2GBI	rat DPP-IV with xanthine inhibitor 4 分子名称: 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE, Dipeptidyl peptidase 4 著者 Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. 登録日 2006-03-10 公開日 2006-07-04 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors. Biochemistry, 45, 2006
2GBF	rat dpp-IV with alkynyl cyanopyrrolidine #1 分子名称: (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE, Dipeptidyl peptidase 4 著者 Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. 登録日 2006-03-10 公開日 2006-07-04 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors. Biochemistry, 45, 2006
2G9R	The crystal structure of glycogen phosphorylase b in complex with (3R,4R,5R)-5-hydroxymethyl-1-(3-phenylpropyl)-piperidine-3,4-diol 分子名称: (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL, Glycogen phosphorylase, muscle form 著者 Oikonomakos, N.G, Tiraidis, C, Leonidas, D.D, Zographos, S.E. 登録日 2006-03-07 公開日 2007-01-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. J.Med.Chem., 49, 2006
1FMO	CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE 分子名称: ADENOSINE, CAMP-DEPENDENT PROTEIN KINASE, HEAT STABLE RABBIT SKELETAL MUSCLE INHIBITOR PROTEIN 著者 Narayana, N, Cox, S, Shaltiel, S, Taylor, S.S, Xuong, N.-H. 登録日 1997-07-08 公開日 1998-01-14 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry, 36, 1997
1HQF	CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH N-HYDROXY-L-ARGININE 分子名称: ARGINASE 1, MANGANESE (II) ION, N-OMEGA-HYDROXY-L-ARGININE 著者 Cox, J.D, Cama, E, Colleluori, D.M, Ash, D.E, Christianson, D.W. 登録日 2000-12-16 公開日 2001-04-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry, 40, 2001
1HQG	CRYSTAL STRUCTURE OF THE H141C ARGINASE VARIANT COMPLEXED WITH PRODUCTS ORNITHINE AND UREA 分子名称: ARGINASE 1, L-ornithine, MANGANESE (II) ION, ... 著者 Cox, J.D, Cama, E, Colleluori, D.M, Ash, D.E, Christianson, D.W. 登録日 2000-12-16 公開日 2001-04-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry, 40, 2001
1HQX	R308K ARGINASE VARIANT 分子名称: ARGINASE, MANGANESE (II) ION 著者 Lavulo, L.T, Sossong Jr, T.M, Brigham-Burke, M.R, Doyle, M.L, Cox, J.D, Christianson, D.W, Ash, D.E. 登録日 2000-12-20 公開日 2001-06-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid. J.Biol.Chem., 276, 2001
1HQ5	CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE 分子名称: ARGINASE 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE 著者 Kim, N.N, Cox, J.D, Baggio, R.F, Emig, F.A, Mistry, S.K, Harper, S.L, Speicher, D.W, Morris Jr, S.M, Ash, D.E, Traish, A, Christianson, D.W. 登録日 2000-12-14 公開日 2001-04-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry, 40, 2001
1HQH	CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH NOR-N-HYDROXY-L-ARGININE 分子名称: ARGINASE 1, MANGANESE (II) ION, NOR-N-OMEGA-HYDROXY-L-ARGININE 著者 Cox, J.D, Cama, E, Colleluori, D.M, Ash, D.E, Christianson, D.W. 登録日 2000-12-16 公開日 2001-04-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry, 40, 2001
1J3H	Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, cAMP-dependent protein kinase, alpha-catalytic subunit 著者 Akamine, P, Madhusudan, Wu, J, Xuong, N.H, Ten Eyck, L.F, Taylor, S.S. 登録日 2003-01-31 公開日 2003-03-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Dynamic Features of cAMP-dependent Protein Kinase Revealed by Apoenzyme Crystal Structure J.Mol.Biol., 327, 2003
6FRX	PKA variant as Aurora B mimic in complex with a dianilinopyrimidine inhibitor 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}-[3-[(5-chloranyl-2-phenylazanyl-pyrimidin-4-yl)amino]phenyl]prop-2-enamide 著者 Engh, R.A, Kazi, A.A. 登録日 2018-02-16 公開日 2019-03-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 PKA variant as Aurora B mimic in complex with a dianilinopyrimidine inhibitor To Be Published
4UBG	Resting state of rat cysteine dioxygenase C93G variant 分子名称: Cysteine dioxygenase type 1, FE (II) ION, SODIUM ION 著者 Fellner, M, Tchesnokov, E.P, Jameson, G.N, Wilbanks, S.M. 登録日 2014-08-13 公開日 2014-11-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Cys-Tyr Cross-Link of Cysteine Dioxygenase Changes the Optimal pH of the Reaction without a Structural Change. Biochemistry, 53, 2014
4UJA	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one, BROMIDE ION, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-09 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJ2	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-iodanylphenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-07 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.019 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJB	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-fluorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-09 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJ9	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-[4-(trifluoromethyl)phenyl]carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-09 公開日 2016-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJ1	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-07 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.768 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4WB7	Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A (catalytic alpha subunit) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, PKI (5-24), ... 著者 Cheung, J, Ginter, C, Cassidy, M, Franklin, M.C, Rudolph, M.J, Hendrickson, W.A. 登録日 2014-09-02 公開日 2015-01-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112, 2015
4WBB	Single Turnover Autophosphorylation Cycle of the PKA RIIb Holoenzyme 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Zhang, P, Knape, M.J, Ahuja, L.G, Keshwani, M.M, King, C.C, Sastri, M, Herberg, F.W, Taylor, S.S. 登録日 2014-09-02 公開日 2015-05-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme. Plos Biol., 13, 2015
6Q81	Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state 分子名称: ADENOSINE-5'-DIPHOSPHATE, P-glycoprotein (ABCB1) 著者 Ford, R.C, Thonghin, N, Collins, R.F, Barbieri, A, Shafi, T, Siebert, A. 登録日 2018-12-13 公開日 2018-12-26 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 angstrom resolution. Bmc Struct.Biol., 18, 2018
4WB8	Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit), exon 1 deletion 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Cheung, J, Ginter, C, Cassidy, M, Franklin, M.C, Rudolph, M.J, Hendrickson, W.A. 登録日 2014-09-02 公開日 2015-01-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112, 2015
6QJ7	Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}'-[(2~{S})-2-[3,5-bis(fluoranyl)phenyl]-2-oxidanyl-ethanoyl]-2-ethyl-3-methyl-4-oxidanyl-benzohydrazide 著者 Graedler, U. 登録日 2019-01-23 公開日 2020-02-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) To Be Published
6Q6H	Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class 分子名称: Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 13, ... 著者 Zhang, S, Barford, D. 登録日 2018-12-11 公開日 2019-09-11 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. Nat Commun, 10, 2019
6I2H	Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp190 分子名称: CHLORIDE ION, UPF0418 protein FAM164A, [2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acid, ... 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2018-11-01 公開日 2019-11-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp190 To be published

<45678910111213141516171819>