PDB: 30867 件ウェブページステータス検索Chemie searchBIRD

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7MP3	Grb7-SH2 domain in complex with bicyclic peptide B8 分子名称: Growth factor receptor-bound protein 7, bicyclic peptide B8 著者 Colson, R, Wilce, M.C.J, Wilce, J.A. 登録日 2021-05-04 公開日 2022-02-02 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability. Biomedicines, 10, 2022
5UHP	Crystal structure of the core catalytic domain of human O-GlcNAcase 分子名称: GLYCEROL, O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain 著者 Klein, D.J, Elsen, N.L. 登録日 2017-01-11 公開日 2017-03-29 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition To Be Published
5TYQ	Crystal structure of a holoenzyme methyltransferase involved in the biosynthesis of gentamicin 分子名称: MAGNESIUM ION, Putative gentamicin methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Bury, P, Huang, F, Leadlay, P, Dias, M.V.B. 登録日 2016-11-21 公開日 2017-11-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.163 Å) 主引用文献 Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chem. Biol., 12, 2017
7MU8	Structure of the minimally glycosylated human CEACAM1 N-terminal domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, ... 著者 Belcher Dufrisne, M, Swope, N, Kieber, M, Yang, J.Y, Han, J, Li, J, Moremen, K.W, Prestegard, J.H, Columbus, L. 登録日 2021-05-14 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Human CEACAM1 N-domain dimerization is independent from glycan modifications. Structure, 30, 2022
5TZE	Crystal structure of S. aureus TarS in complex with UDP-GlcNAc 分子名称: Glycosyl transferase, MANGANESE (II) ION, SULFATE ION, ... 著者 Worrall, L.J, Sobhanifar, S, King, D.T, Strynadka, N.C. 登録日 2016-11-21 公開日 2017-01-04 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid beta-glycosyltransferase Involved in Methicillin Resistance. PLoS Pathog., 12, 2016
6HEH	Structure of the catalytic domain of USP28 (insertion deleted) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28 著者 Gersch, M, Komander, D. 登録日 2018-08-20 公開日 2019-03-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
6HEI	Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA 分子名称: 1,2-ETHANEDIOL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28 著者 Gersch, M, Komander, D. 登録日 2018-08-20 公開日 2019-03-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
7MLN	Crystal structure of ricin A chain in complex with 5-(o-tolyl)thiophene-2-carboxylic acid 分子名称: 5-(2-methylphenyl)thiophene-2-carboxylic acid, GLYCEROL, Ricin 著者 Harijan, R.K, Li, X.P, Cao, B, Augeri, D, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. 登録日 2021-04-28 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 64, 2021
6HEU	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT058 分子名称: 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide, Ephrin type-A receptor 2 著者 Kudlinzki, D, Troester, A, Witt, K, Linhard, V.L, Gande, S.L, Saxena, K, Schwalbe, H. 登録日 2018-08-20 公開日 2019-08-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.719 Å) 主引用文献 Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity To Be Published
6BPH	Crystal structure of the chromodomain of RBBP1 分子名称: AT-rich interactive domain-containing protein 4A, UNKNOWN ATOM OR ION 著者 Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2017-11-23 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of chromo barrel domain of RBBP1. Biochem. Biophys. Res. Commun., 496, 2018
5U04	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase 分子名称: PHOSPHATE ION, ZINC ION, Zika Virus NS5 RdRp 著者 Godoy, A.S, Lima, G.M.A, Oliveira, K.I.Z, Torres, N.U, Maluf, F.V, Guido, R.V.C, Oliva, G. 登録日 2016-11-22 公開日 2017-02-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase. Nat Commun, 8, 2017
5TVU	Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg 分子名称: ADENOSINE-5'-TRIPHOSPHATE, TNF receptor-associated protein 1 著者 Elnatan, D, Betegon, M, Agard, D.A. 登録日 2016-11-10 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1. Elife, 6, 2017
5U0E	Identification of a New Zinc Binding Chemotype by Fragment Screening 分子名称: (5R)-5-benzyl-2-sulfanylidene-1,3-thiazolidin-4-one, 1,2-ETHANEDIOL, Carbonic anhydrase 2, ... 著者 Peat, T.S, Poulsen, S.A, Ren, B, Dolezal, O, Woods, L.A, Mujumdar, P, Chrysanthopoulos, P.K. 登録日 2016-11-23 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
5TWE	CTX-M-14 P167S:S70G mutant enzyme crystallized with ceftazidime 分子名称: ACYLATED CEFTAZIDIME, Beta-lactamase 著者 Patel, M, Stojanoski, V, Sankaran, B, Prasad, B.V.V, Palzkill, T. 登録日 2016-11-12 公開日 2017-06-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry, 56, 2017
6HE1	Pseudomonas aeruginosa Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine 分子名称: 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, SODIUM ION, ... 著者 Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. 登録日 2018-08-20 公開日 2019-12-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
5U0N	Crystal structure of a methyltransferase in complex with the substrate involved in the biosynthesis of gentamicin 分子名称: (1R,2S,3S,4R,6S)-4,6-diamino-3-[(3-amino-3-deoxy-alpha-D-xylopyranosyl)oxy]-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, MAGNESIUM ION, Putative gentamicin methyltransferase, ... 著者 Bury, P, Huang, F, Li, S, Sun, Y, Leadlay, P, Dias, M.V.B. 登録日 2016-11-25 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.115 Å) 主引用文献 Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chem. Biol., 12, 2017
6HFJ	Human dihydroorotase mutant F1563A co-crystallized with carbamoyl aspartate at pH 7.5 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 Ramon-Maiques, S, Grande Garcia, A. 登録日 2018-08-21 公開日 2018-10-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
7MLO	Crystal structure of ricin A chain in complex with 5-mesitylthiophene-2-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 5-(2,4,6-trimethylphenyl)thiophene-2-carboxylic acid, Ricin, ... 著者 Harijan, R.K, Li, X.P, Cao, B, Augeri, D, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. 登録日 2021-04-28 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 64, 2021
6BVE	Triosephosphate isomerase of Synechocystis in complex with 2-Phosphoglycolic acid 分子名称: 2-PHOSPHOGLYCOLIC ACID, SODIUM ION, Triosephosphate isomerase 著者 Jimenez-Sandoval, P, Castro-Torres, E, Brieba, L.G. 登録日 2017-12-12 公開日 2018-12-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural Basis for the Limited Response to Oxidative and Thiol-Conjugating Agents by Triosephosphate Isomerase From the Photosynthetic BacteriaSynechocystis. Front Mol Biosci, 5, 2018
7M6K	Crystal structure of the ARM domain from Drosophila SARM1 in complex with VMN 分子名称: 3-({[(4-nitrophenyl)carbamoyl]amino}methyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium, Isoform B of NAD(+) hydrolase sarm1, SODIUM ION 著者 Gu, W, Luo, Z, Kobe, B. 登録日 2021-03-25 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1. Elife, 10, 2021
6HFS	Human dihydroorotase mutant F1563Y co-crystallized with carbamoyl aspartate at pH 6.5 分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... 著者 Ramon-Maiques, S, Grande Garcia, A. 登録日 2018-08-21 公開日 2018-10-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.34904516 Å) 主引用文献 Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HEG	Crystal structure of Escherichia coli DEAH/RHA helicase HrpB 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase HrpB, PHOSPHATE ION, ... 著者 Xin, B.G, Chen, W.F, Rety, S, Dai, Y.X, Xi, X.G. 登録日 2018-08-20 公開日 2018-09-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.019 Å) 主引用文献 Crystal structure of Escherichia coli DEAH/RHA helicase HrpB. Biochem. Biophys. Res. Commun., 504, 2018
7M0Y	Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. 登録日 2021-03-11 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
6BVZ	Importin alpha 3 in cargo free state 分子名称: Importin subunit alpha-3 著者 Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. 登録日 2017-12-14 公開日 2018-07-04 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
5GUI	Crystal structure of the N-terminal Domain of Caseinolytic protease associated chaperone ClpC1 from Arabidopsis thaliana 分子名称: Chaperone protein ClpC1, chloroplastic, PHOSPHATE ION 著者 Jagdev, M.K, Vasudevan, D. 登録日 2016-08-29 公開日 2017-03-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structures reveal N-terminal Domain of Arabidopsis thaliana ClpD to be highly divergent from that of ClpC1. Sci Rep, 7, 2017

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