PDB: 30867 件ウェブページステータス検索Chemie searchBIRD

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7MON	Structure of human RIPK3-MLKL complex 分子名称: Mixed lineage kinase domain-like protein, N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 3 著者 Meng, Y, Davies, K.A, Czabotar, P.E, Murphy, J.M. 登録日 2021-05-03 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nat Commun, 12, 2021
8TE9	Crystal Structure of an Isethionate bound Substrate Binding Protein (IseP) from an Isethionate TRAP Transporter 分子名称: 1,2-ETHANEDIOL, 2-hydroxyethylsulfonic acid, Isethionate-binding periplasmic protein DctP, ... 著者 Newton-Vesty, M.C, Dobson, R.C.J. 登録日 2023-07-05 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Crystal structure of an isethionate substrate-binding protein (IseP) bound to isethionate To Be Published
6CKN	Crystal structure of an AF10 fragment 分子名称: Protein AF-10, UNKNOWN ATOM OR ION 著者 Qin, S, Tempel, W, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-02-28 公開日 2018-03-21 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. Genes Dev., 32, 2018
5I3F	Structure-Function Studies on Role of Hydrophobic Clamping of a Basic Glutamate in Catalysis by Triosephosphate Isomerase 分子名称: Triosephosphate isomerase, glycosomal 著者 Drake, E.J, Gulick, A.M, Richard, J.P, Zhai, X, Kim, K, Reinhardt, C.J. 登録日 2016-02-10 公開日 2016-05-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase. Biochemistry, 55, 2016
6RRH	GOLGI ALPHA-MANNOSIDASE II 分子名称: 1,2-ETHANEDIOL, Alpha-mannosidase 2, ZINC ION 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-18 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
8TFW	FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, boronic acid-based compound N34 bound 分子名称: Fluorophosphonate-binding serine hydrolase E, MAGNESIUM ION, [5-(trifluoromethyl)thiophen-2-yl]boronic acid 著者 Fellner, M. 登録日 2023-07-12 公開日 2024-07-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, boronic acid-based compound N34 bound To Be Published
6RTI	X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with aptamer A9g 分子名称: (2S)-2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Motlova, L, Kolenko, P, Barinka, C. 登録日 2019-05-24 公開日 2020-06-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer. Nucleic Acids Res., 48, 2020
8TGT	Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein 分子名称: 1,2-ETHANEDIOL, C4b-binding protein alpha chain, CALCIUM ION, ... 著者 Kolesinski, P, Ghosh, P. 登録日 2023-07-13 公開日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein To Be Published
5I3U	STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE N-SITE COMPLEX; CATALYTIC INCORPORATION OF AZTMP to A DNA aptamer in CRYSTAL 分子名称: DNA (39-MER), GLYCEROL, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, ... 著者 Das, K, Arnold, E. 登録日 2016-02-11 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. Acs Chem.Biol., 11, 2016
5I4S	Non-natural DNA pair Z (6-amino-5-nitro-2[1H] pyridone heterocycle)-Guanosine 分子名称: CALCIUM ION, DNA (5'-D(P*GP*CP*GP*AP*AP*TP*TP*(D8Z)P*GP*CP*G)-3') 著者 Ahmad Sobri, A.F, Brady, R.L. 登録日 2016-02-12 公開日 2017-02-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Non-natural DNA pair Z (6-amino-5-nitro-2[1H] pyridone heterocycle)-Guanosine To Be Published
6RTW	Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Llama-derived nanobody NB64, ... 著者 Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. 登録日 2019-05-27 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
5FKB	Structure of D80A-fructofuranosidase from Xanthophyllomyces dendrorhous complexed with 1-Kestose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-FRUCTOFURANOSIDASE, ... 著者 Ramirez-Escudero, M, Sanz-Aparicio, J. 登録日 2015-10-15 公開日 2016-02-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural Analysis of Beta-Fructofuranosidase from Xanthophyllomyces Dendrorhous Reveals Unique Features and the Crucial Role of N-Glycosylation in Oligomerization and Activity J.Biol.Chem., 291, 2016
8TJH	TGP-E, extreme thermostable green fluorescent protein (TGP) with Q66E mutation 分子名称: 4-[(4Z)-1-(CARBOXYMETHYL)-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]-4-IMINOBUTANOIC ACID, extreme thermostable green fluorescent protein (TGP-E) 著者 Anderson, M.R, DeVore, N.D. 登録日 2023-07-21 公開日 2024-07-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 TGP-E, extreme thermostable green fluorescent protein (TGP) with Q66E mutation To Be Published
5F83	Imipenem complex of the GES-5 C69G mutant 分子名称: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase 著者 Smith, C.A, Vakulenko, S.B. 登録日 2015-12-09 公開日 2016-09-07 最終更新日 2019-12-11 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Role of the Conserved Disulfide Bridge in Class A Carbapenemases. J.Biol.Chem., 291, 2016
6RSE	Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class 分子名称: Tyrosine-protein kinase JAK1, methyl ~{N}-[4-aminocarbonyl-1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate 著者 Brown, D.G, Lupardus, P.J. 登録日 2019-05-21 公開日 2020-07-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published
6D4C	Crystal structure of Candida boidinii formate dehydrogenase V123G mutant complexed with NAD+ and azide 分子名称: AZIDE ION, CHLORIDE ION, Formate dehydrogenase, ... 著者 Guo, Q, Ye, H, Gakhar, L, Cheatum, C.M, Kohen, A. 登録日 2018-04-17 公開日 2019-04-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase Acs Catalysis, 2019
6IU7	Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type) 分子名称: Importin subunit alpha-1, Peptide from TP53-binding protein 1 著者 Matsuura, Y. 登録日 2018-11-27 公開日 2019-01-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha. Biochem. Biophys. Res. Commun., 510, 2019
6RTD	Dihydro-heme d1 dehydrogenase NirN in complex with DHE 分子名称: (R,R)-2,3-BUTANEDIOL, Cytochrome c, HEME C, ... 著者 Kluenemann, T, Preuss, A, Layer, G, Blankenfeldt, W. 登録日 2019-05-23 公開日 2019-06-19 最終更新日 2019-08-28 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Crystal Structure of Dihydro-Heme d1Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis. J.Mol.Biol., 431, 2019
8TGF	Crystal structure of cEPG5 LIR/LGG-1 complex 分子名称: ACETATE ION, Ectopic P granules protein 5, Protein lgg-1 著者 Cheung, Y.W.S, Yip, C.K. 登録日 2023-07-12 公開日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular basis of the mode of interaction between the tandem LC3-interacting region motif of the autophagy tethering factor EPG5 and ATG8 proteins To be published
6RVC	Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody NB75, Protein patched homolog 1, ... 著者 Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. 登録日 2019-05-31 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
6D7F	Bacteroides uniformis beta-glucuronidase 1 bound to thiophenyl-beta-D-glucuronide 分子名称: Beta-galactosidase/beta-glucuronidase, CHLORIDE ION, GLYCEROL, ... 著者 Walton, W.G, Pellock, S.J, Redinbo, M.R. 登録日 2018-04-24 公開日 2018-10-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
5FA2	Crystal structure of 426c.TM4deltaV1-3 p120 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, THIOCYANATE ION, ... 著者 Scharf, L, Bjorkman, P.J. 登録日 2015-12-10 公開日 2016-04-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for germline antibody recognition of HIV-1 immunogens. Elife, 5, 2016
6D8K	Bacteroides multiple species beta-glucuronidase 分子名称: Glycosyl hydrolase family 2, sugar binding domain protein 著者 Walton, W.G, Pellock, S.J, Redinbo, M.R. 登録日 2018-04-26 公開日 2018-10-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
8TLR	Crystal Structure of human HRAS G12C covalently bound to AMG 510 分子名称: AMG 510 (bound form), GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Morstein, J, Guiley, K.Z, Shokat, K.M. 登録日 2023-07-27 公開日 2024-07-31 実験手法 X-RAY DIFFRACTION (1.70003951 Å) 主引用文献 Targeting Ras-, Rho-, and Rab-Family GTPases via a Conserved Cryptic Pocket To Be Published
5FAT	OXA-48 in complex with FPI-1602 分子名称: Beta-lactamase, CADMIUM ION, CHLORIDE ION, ... 著者 King, A.M, King, D.T, French, S, Brouillette, E, Asli, A, Alexander, A.N, Vuckovic, M, Maiti, S.N, Parr, T.R, Brown, E.D, Malouin, F, Strynadka, N.C.J, Wright, G.D. 登録日 2015-12-12 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins. Acs Chem.Biol., 11, 2016

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