6W2J
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![BU of 6w2j by Molmil](/molmil-images/mine/6w2j) | CPS1 bound to allosteric inhibitor H3B-374 | 分子名称: | (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ... | 著者 | Larsen, N.A, Nguyen, T.V. | 登録日 | 2020-03-05 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1. Acs Med.Chem.Lett., 11, 2020
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1M6V
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![BU of 1m6v by Molmil](/molmil-images/mine/1m6v) | Crystal Structure of the G359F (small subunit) Point Mutant of Carbamoyl Phosphate Synthetase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, L-ornithine, ... | 著者 | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | 登録日 | 2002-07-17 | 公開日 | 2002-07-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia J.Biol.Chem., 277, 2002
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1A9X
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![BU of 1a9x by Molmil](/molmil-images/mine/1a9x) | |
6UEL
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![BU of 6uel by Molmil](/molmil-images/mine/6uel) | CPS1 bound to allosteric inhibitor H3B-193 | 分子名称: | Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ... | 著者 | Larsen, N.A, Nguyen, T.V. | 登録日 | 2019-09-21 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol, 27, 2020
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1T36
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![BU of 1t36 by Molmil](/molmil-images/mine/1t36) | Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthase large chain, ... | 著者 | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | 登録日 | 2004-04-24 | 公開日 | 2004-09-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Long-range allosteric transitions in carbamoyl phosphate synthetase. Protein Sci., 13, 2004
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5DOU
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![BU of 5dou by Molmil](/molmil-images/mine/5dou) | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | de Cima, S, Polo, L.M, Fita, I, Rubio, V. | 登録日 | 2015-09-11 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
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1JDB
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![BU of 1jdb by Molmil](/molmil-images/mine/1jdb) | CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE, CHLORIDE ION, ... | 著者 | Thoden, J.B, Holden, H.M, Wesenberg, G, Raushel, F.M, Rayment, I. | 登録日 | 1997-03-25 | 公開日 | 1998-06-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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5DOT
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![BU of 5dot by Molmil](/molmil-images/mine/5dot) | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form | 分子名称: | 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ... | 著者 | Polo, L.M, de Cima, S, Fita, I, Rubio, V. | 登録日 | 2015-09-11 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
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1KEE
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![BU of 1kee by Molmil](/molmil-images/mine/1kee) | Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthetase large chain, ... | 著者 | Miles, B.W, Thoden, J.B, Holden, H.M, Raushel, F.M. | 登録日 | 2001-11-15 | 公開日 | 2001-12-21 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. J.Biol.Chem., 277, 2002
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1CE8
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![BU of 1ce8 by Molmil](/molmil-images/mine/1ce8) | CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, INOSINIC ACID, ... | 著者 | Thoden, J.B, Raushel, F.M, Holden, H.M. | 登録日 | 1999-03-18 | 公開日 | 1999-07-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase. J.Biol.Chem., 274, 1999
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1C30
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![BU of 1c30 by Molmil](/molmil-images/mine/1c30) | CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... | 著者 | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | 登録日 | 1999-07-24 | 公開日 | 1999-12-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry, 38, 1999
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1C3O
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![BU of 1c3o by Molmil](/molmil-images/mine/1c3o) | CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... | 著者 | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | 登録日 | 1999-07-28 | 公開日 | 1999-12-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry, 38, 1999
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1BXR
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![BU of 1bxr by Molmil](/molmil-images/mine/1bxr) | STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP | 分子名称: | CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... | 著者 | Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. | 登録日 | 1998-10-08 | 公開日 | 1999-04-20 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding. Biochemistry, 38, 1999
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1CS0
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![BU of 1cs0 by Molmil](/molmil-images/mine/1cs0) | Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... | 著者 | Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. | 登録日 | 1999-08-16 | 公開日 | 1999-12-10 | 最終更新日 | 2019-11-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry, 38, 1999
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