6XIW
 
 | | Cryo-EM structure of the sodium leak channel NALCN-FAM155A complex | | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kschonsak, M, Chua, H.C, Noland, C.L, Weidling, C, Clairfeuille, T, Bahlke, O.O, Ameen, A.O, Li, Z.R, Arthur, C.P, Ciferri, C, Pless, S.A, Payandeh, J. | | 登録日 | 2020-06-22 | | 公開日 | 2020-07-29 | | 最終更新日 | 2020-11-25 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure of the human sodium leak channel NALCN.
Nature, 587, 2020
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2KYH
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4BGN
 | | cryo-EM structure of the NavCt voltage-gated sodium channel | | 分子名称: | VOLTAGE-GATED SODIUM CHANNEL | | 著者 | Tsai, C.J, Tani, K, Irie, K, Hiroaki, Y, Shimomura, T, Mcmillan, D.G, Cook, G.M, Schertler, G, Fujiyoshi, Y, Li, X.D. | | 登録日 | 2013-03-28 | | 公開日 | 2013-07-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (9 Å) | | 主引用文献 | Two Alternative Conformations of a Voltage-Gated Sodium Channel.
J.Mol.Biol., 425, 2013
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6E1N
 | | Structure of AtTPC1(DDE) in state 1 | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CALCIUM ION, PALMITIC ACID, ... | | 著者 | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | | 登録日 | 2018-07-10 | | 公開日 | 2018-09-19 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6E1K
 | | Structure of AtTPC1(DDE) reconstituted in saposin A with cat06 Fab | | 分子名称: | CALCIUM ION, PALMITIC ACID, Two pore calcium channel protein 1, ... | | 著者 | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | | 登録日 | 2018-07-10 | | 公開日 | 2018-09-19 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4G80
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4G7V
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4G7Y
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5DQQ
 | | Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana | | 分子名称: | CALCIUM ION, PALMITIC ACID, Two pore calcium channel protein 1, ... | | 著者 | Kintzer, A.F, Stroud, R.M. | | 登録日 | 2015-09-15 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.872 Å) | | 主引用文献 | Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana
Nature, 531, 2016
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5E1J
 | | Structure of voltage-gated two-pore channel TPC1 from Arabidopsis thaliana | | 分子名称: | BARIUM ION, CALCIUM ION, Two pore calcium channel protein 1 | | 著者 | Guo, J, Zeng, W, Chen, Q, Lee, C, Chen, L, Yang, Y, Jiang, Y. | | 登録日 | 2015-09-29 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.308 Å) | | 主引用文献 | Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana.
Nature, 531, 2016
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5OQK
 | | Solution NMR structure of truncated, human Hv1/VSOP (Voltage-gated proton channel) | | 分子名称: | Voltage-gated hydrogen channel 1 | | 著者 | Bayrhuber, M, Maslennikov, I, Kwiatowski, W, Sobol, A, Wierschem, C, Eichmann, C, Riek, R. | | 登録日 | 2017-08-12 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Nuclear Magnetic Resonance Solution Structure and Functional Behavior of the Human Proton Channel.
Biochemistry, 58, 2019
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7CU3
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7CM3
 | | Cryo-EM structure of human NALCN in complex with FAM155A | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, J, Yan, Z, Ke, M. | | 登録日 | 2020-07-24 | | 公開日 | 2020-11-11 | | 最終更新日 | 2020-12-02 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of the human sodium leak channel NALCN in complex with FAM155A.
Nat Commun, 11, 2020
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8J7F
 | | ion channel | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | | 著者 | Chen, H.W, Chen, H.W. | | 登録日 | 2023-04-27 | | 公開日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | structure of ion channel
To Be Published
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8OUO
 | | Human TPC2 in Complex with Antagonist (S)-SG-094 | | 分子名称: | (1S)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | | 著者 | Chi, G, Pike, A.C.W, Maclean, E.M, Li, H, Mukhopadhyay, S.M.M, Bohstedt, T, Wang, D, McKinley, G, Fernandez-Cid, A, Duerr, K. | | 登録日 | 2023-04-24 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
Structure, 32, 2024
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6MIE
 | | Solution NMR structure of the KCNQ1 voltage-sensing domain | | 分子名称: | Potassium voltage-gated channel subfamily KQT member 1 | | 著者 | Taylor, K.C, Kuenze, G, Smith, J.A, Meiler, J, McFeeters, R.L, Sanders, C.R. | | 登録日 | 2018-09-19 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
Elife, 9, 2020
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6NQ1
 | | Cryo-EM structure of human TPC2 channel in the apo state | | 分子名称: | Two pore calcium channel protein 2 | | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2019-01-18 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
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7PGF
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6NQ0
 | | Cryo-EM structure of human TPC2 channel in the ligand-bound open state | | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2019-01-18 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
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6NQ2
 | | Cryo-EM structure of human TPC2 channel in the ligand-bound closed state | | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2019-01-18 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
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5TUA
 | | structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1 | | 分子名称: | BARIUM ION, CALCIUM ION, SODIUM ION, ... | | 著者 | Guo, J, Zeng, W, Jiang, Y. | | 登録日 | 2016-11-05 | | 公開日 | 2017-01-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Tuning the ion selectivity of two-pore channels.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6V1Q
 | | Two-pore channel 3 | | 分子名称: | SODIUM ION, Two pore channel 3 | | 著者 | Dickinson, M.S, Stroud, R.M. | | 登録日 | 2019-11-20 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Resting state structure of the hyperdepolarization activated two-pore channel 3.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6C9A
 | | Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state | | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | She, J, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2018-01-25 | | 公開日 | 2018-04-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.
Nature, 556, 2018
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6C96
 | | Cryo-EM structure of mouse TPC1 channel in the apo state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | | 著者 | She, J, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2018-01-25 | | 公開日 | 2018-04-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.
Nature, 556, 2018
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6CX0
 | | Structure of AtTPC1 D376A | | 分子名称: | (1S,3R)-1-(3-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid, CALCIUM ION, Two pore calcium channel protein 1 | | 著者 | Kintzer, A.F, Stroud, R.M. | | 登録日 | 2018-04-02 | | 公開日 | 2018-09-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.501 Å) | | 主引用文献 | Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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