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PDB: 118 件
8OJO
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Galectin-3 in complex with 2,6-Anhydro-5-S-(beta-D-galactopyranosyl)-5-thio-D-altritol
分子名称: 1-deoxy-alpha-D-mannopyranose, 1-thio-beta-D-galactopyranose, Galectin-3, ...
著者Tsagkarakou, A.S, Leonidas, D.D.
登録日2023-03-24
公開日2023-09-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds.
J.Med.Chem., 66, 2023
8PPN
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Galectin-3 carbohydrate recognition domain in complex with thiodigalactoside at 1.8 resolution
分子名称: 1-thio-beta-D-galactopyranose-(1-1)-beta-D-galactopyranose, CHLORIDE ION, GLYCEROL, ...
著者Tsagkarakou, A.S, Leonidas, D.D.
登録日2023-07-07
公開日2023-09-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds.
J.Med.Chem., 66, 2023
5NF9
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Structure of Galectin-3 CRD in complex with compound 2
分子名称: Galectin-3, ~{N}-[(2~{R},3~{R},4~{R},5~{S},6~{R})-2-acetamido-6-(hydroxymethyl)-5-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4-oxidanyl-oxan-3-yl]-3-methoxy-benzamide
著者Ronin, C, Atmanene, C, Gautier, F.M, Djedaini Pilard, F, Teletchea, S, Ciesielski, F, Vivat Hannah, V, Grandjean, C.
登録日2017-03-13
公開日2017-06-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3.
Biochem. Biophys. Res. Commun., 489, 2017
3AYD
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BU of 3ayd by Molmil
Crystal structure of galectin-3 CRD domian complexed with TFN
分子名称: Galectin-3, P-NITROPHENOL, SULFATE ION, ...
著者Bian, C.F, Li, D.F, Wang, D.C.
登録日2011-05-04
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for distinct binding properties of the human galectins to thomsen-friedenreich antigen
Plos One, 6, 2011
6ZVF
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BU of 6zvf by Molmil
Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide
分子名称: Chimeric Fab M3/38 (L,H), Galectin-3
著者Skerra, A, Eichinger, A.
登録日2020-07-24
公開日2021-04-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo.
Sci Rep, 11, 2021
7RDP
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Crystal structure of human galectin-3 CRD in complex with selenodigalactoside
分子名称: CHLORIDE ION, Galectin-3, beta-D-galactopyranosyl 1-seleno-beta-D-galactopyranoside
著者Kishor, C, Go, R.M, Blanchard, H.
登録日2021-07-10
公開日2022-07-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3.
Int J Mol Sci, 23, 2022
7CXA
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Structure of human Galectin-3 CRD in complex with TD-139 belonging to P31 space group.
分子名称: 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, CHLORIDE ION, Galectin-3
著者Kumar, A.
登録日2020-09-01
公開日2021-09-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3.
Glycobiology, 31, 2021
6Q17
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Crystal structure of Human galectin-3 CRD in complex with Methyl 3-O-[1-(b-D-galactopyranosyl)-1,2,3-triazol-4-yl]-methyl-b-D-galactopyranoside
分子名称: CHLORIDE ION, Galectin-3, methyl 3-O-[(1-beta-D-galactopyranosyl-1H-1,2,3-triazol-4-yl)methyl]-beta-D-galactopyranoside
著者Kishor, C, Blanchard, H.
登録日2019-08-02
公開日2020-04-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development.
Chem.Biol.Drug Des., 96, 2020
6Q0Q
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Crystal structure of Human galectin-3 CRD in complex with Methyl 3-O-(1-{3-O-[1-(b-D-galactopyranosyl)-1,2,3-triazol-4-yl]-methyl-b-D-galactopyranosyl}-1,2,3-triazol-4-yl)-methyl-b-D-galactopyranoside
分子名称: (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[4-[[(2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[4-[[(2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-methoxy-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]-1,2,3-triazol-1-yl]-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]-1,2,3-triazol-1-yl]oxane-3,4,5-triol, CHLORIDE ION, Galectin-3
著者Kishor, C, Blanchard, H.
登録日2019-08-02
公開日2020-04-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.98601174 Å)
主引用文献Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development.
Chem.Biol.Drug Des., 96, 2020
7RDO
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BU of 7rdo by Molmil
Crystal structure of human galectin-3 CRD in complex with diselenodigalactoside
分子名称: (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]diselanyl}oxane-3,4,5-triol (non-preferred name), CHLORIDE ION, Galectin-3, ...
著者Kishor, C, Go, R.M, Blanchard, H.
登録日2021-07-10
公開日2022-07-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3.
Int J Mol Sci, 23, 2022
3AYE
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BU of 3aye by Molmil
Crystal structure of galectin-3 CRD domian complexed with lactose
分子名称: Galectin-3, SULFATE ION, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Bian, C.F, Li, D.F, Wang, D.C.
登録日2011-05-04
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for distinct binding properties of the human galectins to thomsen-friedenreich antigen
Plos One, 6, 2011
3AYA
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Crystal structure of galectin-3 CRD domian complexed with Thomsen-Friedenreich antigen
分子名称: Galectin-3, SULFATE ION, THREONINE, ...
著者Bian, C.F, Li, D.F, Wang, D.C.
登録日2011-05-04
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for distinct binding properties of the human galectins to thomsen-friedenreich antigen
Plos One, 6, 2011
4RL7
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BU of 4rl7 by Molmil
Crystal structure of Human galectin-3 CRD in complex with lactose (pH 7.5, PEG6000)
分子名称: Galectin-3, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Su, J.Y.
登録日2014-10-16
公開日2015-03-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The water network in galectin-3 ligand binding site guides inhibitor design.
Acta Biochim.Biophys.Sin., 47, 2015
5H9P
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Crystal Structure of Human Galectin-3 CRD in Complex with TD139
分子名称: 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, Galectin-3
著者Hsieh, T.J, Lin, H.Y, Lin, C.H.
登録日2015-12-29
公開日2016-06-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
1A3K
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BU of 1a3k by Molmil
X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION
分子名称: GALECTIN-3, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Seetharaman, J, Kanigsberg, A, Slaaby, R, Leffler, H, Barondes, S.H, Rini, J.M.
登録日1998-01-22
公開日1998-07-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
J.Biol.Chem., 273, 1998
6FOF
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Crystal structure of a crystallized variant of h-Gal3: Gal-3[NTS/VII-IX]
分子名称: Galectin-3,Galectin-3, SULFATE ION, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Romero, A, Flores-Ibarra, A, Medrano, F.J.
登録日2018-02-07
公開日2018-07-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystallization of a human galectin-3 variant with two ordered segments in the shortened N-terminal tail.
Sci Rep, 8, 2018
4XBN
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BU of 4xbn by Molmil
Crystal Structure of Human Galectin-3 CRD in Complex with Type 1 N-acetyllactosamine
分子名称: Galectin-3, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Hsieh, T.J, Lin, H.Y, Lin, C.H.
登録日2014-12-17
公開日2015-05-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.208 Å)
主引用文献Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc.
Plos One, 10, 2015
2NMN
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Crystal structure of human galectin-3 carbohydrate-recognising domain at 2.45 angstrom resolution
分子名称: Galectin-3, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Blanchard, H, Collins, P.M.
登録日2006-10-23
公開日2007-03-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols.
Acta Crystallogr.,Sect.D, 63, 2007

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