4NQY
 
 | | The reduced form of MJ0499 | | Descriptor: | Isopropylmalate/citramalate isomerase large subunit, ZINC ION | | Authors: | Hwang, K.Y, Lee, E.H, Lee, K. | | Deposit date: | 2013-11-26 | | Release date: | 2014-05-21 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii
Acta Crystallogr.,Sect.D, 70, 2014
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4NU0
 | | Crystal structure of Adenylate kinase from Streptococcus pneumoniae with Ap5A | | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION | | Authors: | Thach, T.T, Luong, T.T, Lee, S.H, Rhee, D.K. | | Deposit date: | 2013-12-03 | | Release date: | 2014-07-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.485 Å) | | Cite: | Adenylate kinase from Streptococcus pneumoniae is essential for growth through its catalytic activity
FEBS Open Bio, 4, 2014
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4NUR
 | | Crystal structure of thermostable alkylsulfatase SdsAP from Pseudomonas sp. S9 | | Descriptor: | MAGNESIUM ION, PSdsA, ZINC ION | | Authors: | Sun, L.F, Su, Y.T, Zhao, Y.H, Cai, Z.X, Wu, Y. | | Deposit date: | 2013-12-04 | | Release date: | 2014-12-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.761 Å) | | Cite: | Crystal structure of thermostable alkylsulfatase SdsAP from Pseudomonas sp. S9
To be Published
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4NJM
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4NWK
 | | Crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r,2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6-methoxy-1-isoquinolinyl)ox y)-l-prolinamide | | Descriptor: | GLYCEROL, HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide, ... | | Authors: | Muckelbauer, J.K, Klei, H.E. | | Deposit date: | 2013-12-06 | | Release date: | 2014-03-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J.Med.Chem., 57, 2014
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4H8E
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4NLK
 | | Structure of human DNA polymerase beta complexed with 8BrG in the template base-paired with incoming non-hydrolyzable CTP | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', ... | | Authors: | Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. | | Deposit date: | 2013-11-14 | | Release date: | 2014-01-22 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.494 Å) | | Cite: | Structural basis for promutagenicity of 8-halogenated Guanine.
J.Biol.Chem., 289, 2014
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4O2G
 | | Crystal structure of carbomonoxy murine neuroglobin mutant V140W | | Descriptor: | CARBON MONOXIDE, Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Avella, G, Savino, C, Vallone, B. | | Deposit date: | 2013-12-17 | | Release date: | 2014-06-18 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta Crystallogr.,Sect.D, 70, 2014
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4JYA
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | Deposit date: | 2013-03-29 | | Release date: | 2013-06-26 | | Last modified: | 2013-08-21 | | Method: | X-RAY DIFFRACTION (3.098 Å) | | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4J9S
 | | Human DNA polymerase eta-DNA translocated binary complex: with TA base pair | | Descriptor: | DNA (5'-D(*T*AP*TP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*AP*TP*A)-3'), DNA polymerase eta, ... | | Authors: | Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W. | | Deposit date: | 2013-02-16 | | Release date: | 2013-05-01 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4JV5
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein 20, 30S ribosomal protein S10, ... | | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | Deposit date: | 2013-03-25 | | Release date: | 2013-06-26 | | Last modified: | 2013-08-21 | | Method: | X-RAY DIFFRACTION (3.162 Å) | | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4JKY
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4JLB
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4NZI
 | | Crystal structure of murine neuroglobin mutant V140W | | Descriptor: | Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Avella, G, Savino, C, Vallone, B. | | Deposit date: | 2013-12-12 | | Release date: | 2014-06-18 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta Crystallogr.,Sect.D, 70, 2014
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4NZG
 | | Crystal Structure of the N-terminal domain of Moloney murine leukemia virus integrase, Northeast Structural Genomics Consortium Target OR3 | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETATE ION, Integrase p46, ... | | Authors: | Guan, R, Jiang, M, Janjua, H, Maglaqui, M, Zhao, L, Xiao, R, Acton, T.B, Everett, J.K, Roth, M, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2013-12-12 | | Release date: | 2014-02-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.152 Å) | | Cite: | X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition.
Proteins, 85, 2017
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4O07
 | | Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease | | Descriptor: | 2,7,7-trimethyl-9-[8-(2-methylpropyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl]-1,2,3,4,6,7,8,9-octahydro-5H-beta-carbolin-5-one, Heat shock protein HSP 90-alpha | | Authors: | Zuccola, H.J, Ernst, J.T. | | Deposit date: | 2013-12-13 | | Release date: | 2014-04-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Identification of Novel HSP90 alpha / beta Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington's Disease.
J.Med.Chem., 57, 2014
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4K09
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4K06
 | | Crystal structure of MTX-II from Bothrops brazili venom complexed with polyethylene glycol | | Descriptor: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, MTX-II, ... | | Authors: | Fernandes, C.A.H, Comparetti, E.J, Borges, R.J, Fontes, M.R.M. | | Deposit date: | 2013-04-03 | | Release date: | 2013-11-13 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structural bases for a complete myotoxic mechanism: Crystal structures of two non-catalytic phospholipases A2-like from Bothrops brazili venom.
Biochim.Biophys.Acta, 1834, 2013
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4K0K
 | | Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | Deposit date: | 2013-04-04 | | Release date: | 2013-06-26 | | Last modified: | 2013-08-21 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4JYU
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4JZK
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4K38
 | | Native anSMEcpe with bound AdoMet and Kp18Cys peptide | | Descriptor: | Anaerobic sulfatase-maturating enzyme, CHLORIDE ION, GLYCEROL, ... | | Authors: | Goldman, P.J, Drennan, C.L. | | Deposit date: | 2013-04-10 | | Release date: | 2013-05-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.831 Å) | | Cite: | X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4K5N
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4JYV
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4KAF
 | | Crystal Structure of Haloalkane dehalogenase HaloTag7 at the resolution 1.5A, Northeast Structural Genomics Consortium (NESG) Target OR151 | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Haloalkane dehalogenase, ... | | Authors: | Kuzin, A.P, Lew, S, Neklesa, T.K, Noblin, D, Seetharaman, J, Maglaqui, M, Xiao, R, Kohan, E, Wang, H, Everett, J.K, Acton, T.B, Kornhaber, G, Montelione, G.T, Crews, C, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2013-04-22 | | Release date: | 2013-06-05 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.496 Å) | | Cite: | Northeast Structural Genomics Consortium Target OR151
To be Published
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