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1L58	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.65 Å) Cite: To be Published
1L64	TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Heinz, D, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc.Natl.Acad.Sci.USA, 89, 1992
1L71	MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992
1L76	TOLERANCE OF T4 LYSOZYME TO PROLINE SUBSTITUTIONS WITHIN THE LONG INTERDOMAIN ALPHA-HELIX ILLUSTRATES THE ADAPTABILITY OF PROTEINS TO POTENTIALLY DESTABILIZING LESIONS Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Sauer, U, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. J.Biol.Chem., 267, 1992
1LHM	THE CRYSTAL STRUCTURE OF A MUTANT LYSOZYME C77(SLASH)95A WITH INCREASED SECRETION EFFICIENCY IN YEAST Descriptor: HUMAN LYSOZYME Authors: Inaka, K, Matsushima, M. Deposit date: 1991-10-02 Release date: 1992-04-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast. J.Biol.Chem., 266, 1991
1D1G	DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA Descriptor: DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Dams, T, Auerbach, G, Bader, G, Ploom, T, Huber, R, Jaenicke, R. Deposit date: 1999-09-16 Release date: 2000-03-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability. J.Mol.Biol., 297, 2000
6T9K	SAGA Core module Descriptor: Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... Authors: Wang, H, Cheung, A, Cramer, P. Deposit date: 2019-10-28 Release date: 2020-01-29 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structure of the transcription coactivator SAGA. Nature, 577, 2020
1ODK	PURINE NUCLEOSIDE PHOSPHORYLASE FROM THERMUS THERMOPHILUS Descriptor: GLYCEROL, PURINE NUCLEOSIDE PHOSPHORYLASE Authors: Tahirov, T.H, Inagaki, E, Miyano, M. Deposit date: 2003-02-19 Release date: 2003-02-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of Purine Nucleoside Phosphorylase from Thermus Thermophilus J.Mol.Biol., 337, 2004
1D2B	THE MMP-INHIBITORY, N-TERMINAL DOMAIN OF HUMAN TISSUE INHIBITOR OF METALLOPROTEINASES-1 (N-TIMP-1), SOLUTION NMR, 29 STRUCTURES Descriptor: Metalloproteinase inhibitor 1 Authors: Wu, B, Arumugam, S, Semenchenko, V, Brew, K, Van Doren, S.R. Deposit date: 1999-09-22 Release date: 1999-12-22 Last modified: 2022-03-23 Method: SOLUTION NMR Cite: NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases. J.Mol.Biol., 295, 2000
1OBF	The crystal structure of Glyceraldehyde 3-phosphate Dehydrogenase from Alcaligenes xylosoxidans at 1.7A resolution. Descriptor: GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, POTASSIUM ION, SULFATE ION, ... Authors: Antonyuk, S.V, Eady, R.R, Strange, R.W, Hasnain, S.S. Deposit date: 2003-01-30 Release date: 2003-06-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Structure of Glyceraldehyde 3-Phosphate Dehydrogenase from Alcaligenes Xylosoxidans at 1.7 A Resolution Acta Crystallogr.,Sect.D, 59, 2003
3OVO	REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK)) Descriptor: OVOMUCOID THIRD DOMAIN CLEAVED RDI Authors: Musil, D, Bode, W. Deposit date: 1991-05-13 Release date: 1993-01-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3*) and from Japanese quail (OMJPQ3*). J.Mol.Biol., 220, 1991
2VGL	AP2 CLATHRIN ADAPTOR CORE Descriptor: ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA-1, ... Authors: Owen, D.J, Collins, B.M, McCoy, A.J, Evans, P.R. Deposit date: 2007-11-14 Release date: 2007-12-25 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular Architecture and Functional Model of the Endocytic Ap2 Complex Cell(Cambridge,Mass.), 109, 2002
4TN4	Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Descriptor: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... Authors: Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Witschel, M.C. Deposit date: 2014-06-03 Release date: 2015-03-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities. J.Med.Chem., 58, 2015
1M7H	Crystal Structure of APS kinase from Penicillium Chrysogenum: Structure with APS soaked out of one dimer Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-PHOSPHOSULFATE, Adenylylsulfate kinase, ... Authors: Lansdon, E.B, Sege, I.H, Fisher, A.J. Deposit date: 2002-07-19 Release date: 2002-11-27 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Ligand-Induced Structural Changes in Adenosine 5'-Phosphosulfate Kinase from Penicillium chrysogenum. Biochemistry, 41, 2002
1XU6	Structure of the C-terminal domain from Trypanosoma brucei Variant Surface Glycoprotein MITat1.2 Descriptor: Variant surface glycoprotein MITAT 1.2 Authors: Chattopadhyay, A, Jones, N.G, Nietlispach, D, Nielsen, P.R, Voorheis, H.P, Mott, H.R, Carrington, M. Deposit date: 2004-10-25 Release date: 2004-11-30 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2 J.Biol.Chem., 280, 2004
4RQ3	Precatalytic ternary complex of Human DNA Polymerase Beta With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine (8-oxoG) and dATP in the presence of CaCl2 Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CALCIUM ION, ... Authors: Vyas, R, Suo, Z. Deposit date: 2014-10-31 Release date: 2015-04-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Viewing Human DNA Polymerase beta Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography. J.Am.Chem.Soc., 137, 2015
2CP4	CRYSTAL STRUCTURE OF THE CYTOCHROME P450-CAM ACTIVE SITE MUTANT THR252ALA Descriptor: CAMPHOR, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE Authors: Raag, R, Poulos, T.L. Deposit date: 1991-06-04 Release date: 1993-01-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala. Biochemistry, 30, 1991
4THI	THIAMINASE I FROM BACILLUS THIAMINOLYTICUS WITH COVALENTLY BOUND 4-AMINO-2,5-DIMETHYLPYRIMIDINE Descriptor: 2,5-DIMETHYL-PYRIMIDIN-4-YLAMINE, PROTEIN (THIAMINASE I), SULFATE ION Authors: Campobasso, N, Begley, T.P, Ealick, S.E. Deposit date: 1998-10-05 Release date: 1998-10-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution. Biochemistry, 37, 1998
5VZ7	Pre-catalytic ternary complex of human Polymerase Mu (G433A) mutant with incoming nonhydrolyzable UMPNPP Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... Authors: Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. Deposit date: 2017-05-27 Release date: 2017-07-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.551 Å) Cite: Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
5VZD	Pre-catalytic ternary complex of human Polymerase Mu (W434A) mutant with incoming nonhydrolyzable UMPNPP Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... Authors: Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. Deposit date: 2017-05-27 Release date: 2017-07-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.602 Å) Cite: Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
1AJZ	STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE Descriptor: DIHYDROPTEROATE SYNTHASE, SULFATE ION Authors: Achari, A, Somers, D.O, Champness, J.N, Bryant, P.K, Rosemond, J, Stammers, D.K. Deposit date: 1997-05-13 Release date: 1998-05-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nat.Struct.Biol., 4, 1997
6UZ7	K.lactis 80S ribosome with p/PE tRNA and eIF5B Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0, ... Authors: Fernandez, I.S, Huang, B.Y. Deposit date: 2019-11-14 Release date: 2020-01-15 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation. Proc.Natl.Acad.Sci.USA, 117, 2020
1HKW	MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LysA) Descriptor: DIAMINOPIMELATE DECARBOXYLASE, SULFATE ION Authors: Gokulan, K, Rupp, B, Pavelka Jr, M.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) Deposit date: 2003-03-11 Release date: 2003-03-18 Last modified: 2019-08-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of Mycobacterium Tuberculosis Diaminopimelate Decarboxylase, an Essential Enzyme in Bacterial Lysine Biosynthesis J.Biol.Chem., 278, 2003
1HYH	CRYSTAL STRUCTURE OF L-2-HYDROXYISOCAPROATE DEHYDROGENASE FROM LACTOBACILLUS CONFUSUS AT 2.2 ANGSTROMS RESOLUTION-AN EXAMPLE OF STRONG ASYMMETRY BETWEEN SUBUNITS Descriptor: L-2-HYDROXYISOCAPROATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION Authors: Niefind, K, Hecht, H.-J, Schomburg, D. Deposit date: 1995-06-05 Release date: 1995-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of L-2-hydroxyisocaproate dehydrogenase from Lactobacillus confusus at 2.2 A resolution. An example of strong asymmetry between subunits. J.Mol.Biol., 251, 1995
1AJ9	R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S Descriptor: CARBON MONOXIDE, HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), ... Authors: Vasquez, G.B, Ji, X, Fronticelli, C, Gilliland, G.L. Deposit date: 1997-05-16 Release date: 1998-05-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins. Acta Crystallogr.,Sect.D, 54, 1998

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