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7MGW	5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ... Authors: Yang, D, Gouaux, E. Deposit date: 2021-04-13 Release date: 2021-12-15 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Illumination of serotonin transporter mechanism and role of the allosteric site. Sci Adv, 7, 2021
7LI9	5-HT bound serotonin transporter reconstituted in lipid nanodisc in KCl Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... Authors: Yang, D, Gouaux, E. Deposit date: 2021-01-26 Release date: 2021-12-15 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Illumination of serotonin transporter mechanism and role of the allosteric site. Sci Adv, 7, 2021
7LIA	5-HT bound serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in outward facing conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ... Authors: Yang, D, Gouaux, E. Deposit date: 2021-01-26 Release date: 2021-12-15 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Illumination of serotonin transporter mechanism and role of the allosteric site. Sci Adv, 7, 2021
7LI8	apo serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in inward open conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, DODECANE, ... Authors: Yang, D, Gouaux, E. Deposit date: 2021-01-26 Release date: 2021-12-15 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Illumination of serotonin transporter mechanism and role of the allosteric site. Sci Adv, 7, 2021
7LQK	Crystal structure of the R375A mutant of LeuT Descriptor: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... Authors: Font, J, Aguilar, J, Galli, A, Ryan, R. Deposit date: 2021-02-13 Release date: 2021-05-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. Elife, 10, 2021
7LQJ	Crystal structure of LeuT bound to L-Alanine Descriptor: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... Authors: Font, J, Aguilar, J, Galli, A, Ryan, R. Deposit date: 2021-02-13 Release date: 2021-05-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.144 Å) Cite: Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. Elife, 10, 2021
7LQL	Crystal structure of the R375D mutant of LeuT Descriptor: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... Authors: Font, J, Aguilar, J, Galli, A, Ryan, R. Deposit date: 2021-02-13 Release date: 2021-05-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. Elife, 10, 2021
3TT1	Crystal Structure of LeuT in the outward-open conformation in complex with Fab Descriptor: Leucine transporter LeuT, SODIUM ION, mouse monoclonal 1gG2a Fab fragment, ... Authors: Krishnamurthy, H, Gouaux, E. Deposit date: 2011-09-13 Release date: 2012-01-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.099 Å) Cite: X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature, 481, 2012
3TT3	Crystal Structure of LeuT in the inward-open conformation in complex with Fab Descriptor: Leucine transporter LeuT, mouse monoclonal 1gG1 Fab fragment, heavy chain, ... Authors: Krishnamurthy, H, Gouaux, E. Deposit date: 2011-09-13 Release date: 2012-01-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.22 Å) Cite: X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature, 481, 2012
3TU0	Crystal structure of T355V, S354A, K288A LeuT mutant in complex with alanine and sodium Descriptor: ALANINE, Leucine transporter LeuT, SODIUM ION Authors: Krishnamurthy, H, Gouaux, E. Deposit date: 2011-09-15 Release date: 2012-01-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.994 Å) Cite: X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature, 481, 2012
3QS6	Crystal structure of LeuT mutant F259V,I359Q bound to sodium and L-tryptophan Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ... Authors: Piscitelli, C.L, Gouaux, E. Deposit date: 2011-02-19 Release date: 2011-10-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.801 Å) Cite: Insights into transport mechanism from LeuT engineered to transport tryptophan. Embo J., 31, 2012
3QS4	Crystal structure of LeuT mutant F259V bound to sodium and L-tryptophan Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ... Authors: Piscitelli, C.L, Gouaux, E. Deposit date: 2011-02-19 Release date: 2011-10-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.631 Å) Cite: Insights into transport mechanism from LeuT engineered to transport tryptophan. Embo J., 31, 2012
3USG	Crystal structure of LeuT bound to L-leucine in space group C2 from lipid bicelles Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, LEUCINE, ... Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USJ	Crystal structure of LeuT bound to L-leucine in space group P21 from lipid bicelles Descriptor: LEUCINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USK	Crystal structure of LeuT bound to L-leucine in space group P21 from lipid bicelles Descriptor: LEUCINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USL	Crystal Structure of LeuT bound to L-selenomethionine in space group C2 from lipid bicelles Descriptor: ACETATE ION, IODIDE ION, PHOSPHOCHOLINE, ... Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USO	Crystal structure of LeuT bound to L-selenomethionine in space group P21212 from lipid bicelles Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USI	Crystal structure of LeuT bound to L-leucine in space group P2 from lipid bicelles Descriptor: LEUCINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.106 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
8ZP1	Cryo-EM structure of human norepinephrine transporter NET bound with reboxetine in an outward-open state at a resolution of 2.5 angstrom Descriptor: (2~{S})-2-[(~{S})-(2-ethoxyphenoxy)-phenyl-methyl]morpholine, CHLORIDE ION, Nb_BB4, ... Authors: Song, A.L, Wu, X.D. Deposit date: 2024-05-29 Release date: 2024-09-11 Last modified: 2024-09-18 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter. Cell Res., 2024
8ZP2	Cryo-EM structure of human norepinephrine transporter NET bound with atomoxetine in an outward-open state at a resolution of 2.4 angstrom Descriptor: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, Nb_BB4, ... Authors: Song, A.L, Wu, X.D. Deposit date: 2024-05-29 Release date: 2024-09-11 Last modified: 2024-09-18 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter. Cell Res., 2024
9EUO	Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor Descriptor: 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... Authors: Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. Deposit date: 2024-03-27 Release date: 2024-07-24 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J.Neurochem., 2024
9EO4	Outward-open structure of human dopamine transporter bound to cocaine Descriptor: CHLORIDE ION, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... Authors: Nielsen, J.C, Salomon, K, Kalenderoglou, I.E, Bargmeyer, S, Pape, T, Shahsavar, A, Loland, C.J. Deposit date: 2024-03-14 Release date: 2024-07-03 Last modified: 2024-08-28 Method: ELECTRON MICROSCOPY (2.66 Å) Cite: Structure of the human dopamine transporter in complex with cocaine. Nature, 632, 2024
9EUP	Inhibitor-free outward-open structure of Drosophila dopamine transporter Descriptor: 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... Authors: Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. Deposit date: 2024-03-27 Release date: 2024-07-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J.Neurochem., 2024
8ZPB	Cryo-EM structure of human norepinephrine transporter NET bound with norepinephrine in an occluded state at a resolution of 2.6 angstrom Descriptor: CHLORIDE ION, L-NOREPINEPHRINE, Nb_BB4, ... Authors: Song, A.L, Wu, X.D. Deposit date: 2024-05-29 Release date: 2024-09-11 Last modified: 2024-09-18 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter. Cell Res., 2024
8Y2E	Cryo-EM structure of human dopamine transporter in complex with benztropine Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter, benztropine Authors: Zhao, Y, Li, Y. Deposit date: 2024-01-25 Release date: 2024-08-14 Last modified: 2024-08-28 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: Dopamine reuptake and inhibitory mechanisms in human dopamine transporter. Nature, 632, 2024

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