PDB: 1147 resultsInfo pagesStatus searchChemie searchBIRD

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5AN3	Structure of an Sgt1-Skp1 Complex Descriptor: SGT1, SUPPRESSOR OF KINETOCHORE PROTEIN 1 Authors: Willhoft, O, Vaughan, C.K. Deposit date: 2015-09-03 Release date: 2017-02-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.82 Å) Cite: The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores. Sci Rep, 7, 2017
1ICT	MONOCLINIC FORM OF HUMAN TRANSTHYRETIN COMPLEXED WITH THYROXINE (T4) Descriptor: 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN Authors: Wojtczak, A, Neumann, P, Cody, V. Deposit date: 2001-04-02 Release date: 2002-04-03 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of a new polymorphic monoclinic form of human transthyretin at 3 A resolution reveals a mixed complex between unliganded and T4-bound tetramers of TTR. Acta Crystallogr.,Sect.D, 57, 2001
5BYM	Crystal structure of the RNA-binding domain of yeast Puf5p bound to SMX2 RNA Descriptor: RNA (5'-R(*UP*GP*UP*AP*CP*UP*AP*UP*A)-3'), Suppressor protein MPT5 Authors: Qiu, C, Hall, T.M.T. Deposit date: 2015-06-10 Release date: 2015-09-23 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.708 Å) Cite: RNA regulatory networks diversified through curvature of the PUF protein scaffold. Nat Commun, 6, 2015
5AYT	Crystal structure of transthyretin in complex with L6 Descriptor: 2-oxidanyl-6-(phenylcarbonyl)benzo[de]isoquinoline-1,3-dione, Transthyretin Authors: Yokoyama, T, Mizuguchi, M, Kai, H. Deposit date: 2015-09-03 Release date: 2016-01-20 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione J. Pharmacol. Sci., 129, 2015
1RVS	STRUCTURE OF TRANSTHYRETIN IN AMYLOID FIBRILS DETERMINED BY SOLID-STATE MAGIC ANGLE SPINNING NMR Descriptor: Transthyretin Authors: Jaroniec, C.P, Macphee, C.E, Bajaj, V.S, Mcmahon, M.T, Dobson, C.M, Griffin, R.G. Deposit date: 2003-12-14 Release date: 2004-01-20 Last modified: 2024-05-01 Method: SOLID-STATE NMR Cite: High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy Proc.Natl.Acad.Sci.USA, 101, 2004
3ZPK	Atomic-resolution structure of a quadruplet cross-beta amyloid fibril. Descriptor: TRANSTHYRETIN Authors: Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S.A, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M. Deposit date: 2013-02-28 Release date: 2013-12-04 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY, SOLID-STATE NMR Cite: Atomic Structure and Hierarchical Assembly of a Cross-Beta Amyloid Fibril. Proc.Natl.Acad.Sci.USA, 110, 2013
1TTC	THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION Descriptor: Transthyretin Authors: Hamilton, J.A, Steinrauf, L.K, Braden, B.C. Deposit date: 1992-11-02 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. J.Biol.Chem., 268, 1993
1IJN	Crystal structure of the transthyretin mutant TTR C10A/Y114C Descriptor: BETA-MERCAPTOETHANOL, TRANSTHYRETIN Authors: Eneqvist, T, Karlsson, A, Olofsson, A, Sauer-Eriksson, A.E. Deposit date: 2001-04-27 Release date: 2003-06-03 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cys114-linked dimers of transthyretin are compatible with amyloid formation Biochemistry, 44, 2005
1III	CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT ROOM TEMPERATURE Descriptor: BETA-MERCAPTOETHANOL, TRANSTHYRETIN Authors: Eneqvist, T, Olofsson, A, Ando, Y, Lundgren, E, Sauer-Eriksson, A.E. Deposit date: 2001-04-23 Release date: 2002-11-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Disulfide-Bond Formation in the Transthyretin Mutant Y114C Prevents Amyloid Fibril Formation in Vivo and in Vitro Biochemistry, 41, 2002
2M5N	Atomic-resolution structure of a cross-beta protofilament Descriptor: Transthyretin Authors: Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M. Deposit date: 2013-02-27 Release date: 2013-07-17 Last modified: 2024-05-15 Method: SOLID-STATE NMR Cite: Atomic structure and hierarchical assembly of a cross-{beta} amyloid fibril. Proc.Natl.Acad.Sci.USA, 110, 2013
4HIQ	The Structure of V122I Mutant Transthyretin in Complex with AG10 Descriptor: 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid, Transthyretin Authors: Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. Deposit date: 2012-10-11 Release date: 2013-06-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.18 Å) Cite: AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
4HJS	Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2012-10-14 Release date: 2013-12-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.22 Å) Cite: Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
4HIS	The Structure of V122I Mutant Transthyretin in Complex with Tafamidis Descriptor: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin Authors: Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. Deposit date: 2012-10-11 Release date: 2013-06-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.2 Å) Cite: AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
4HJU	Transthyretin in complex with (E)-N-(3-(4-hydroxy-3,5-dimethylstyryl)phenyl)acrylamide Descriptor: N-{3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}prop-2-enamide, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2012-10-14 Release date: 2013-12-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
4HJT	Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2012-10-14 Release date: 2013-12-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
4I89	Crystal structure of transthyretin in complex with diflunisal at acidic pH Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin Authors: Zanotti, G, Cendron, L, Folli, C, Florio, P, Imbimbo, B.P, Berni, R. Deposit date: 2012-12-03 Release date: 2013-06-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors. Febs Lett., 587, 2013
6TXW	V30G Transthyretin structure in complex with Tolcalpone Descriptor: Tolcapone, Transthyretin Authors: Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. Deposit date: 2020-01-14 Release date: 2020-05-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.153 Å) Cite: Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
6TXV	A25T Transthyretin structure in complex with Tolcalpone Descriptor: Tolcapone, Transthyretin Authors: Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. Deposit date: 2020-01-14 Release date: 2020-05-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
4DES	Crystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR) Descriptor: Transthyretin, chrysin Authors: Trivella, D.B.B, Polikarpov, I. Deposit date: 2012-01-21 Release date: 2012-11-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
4DER	Crystal Structure of the Wild Type TTR Binding Apigenin (TTRwt:API) Descriptor: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, GLYCEROL, Transthyretin Authors: Trivella, D.B.B, Polikarpov, I. Deposit date: 2012-01-21 Release date: 2012-11-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
4IKK	Crystal structure of wild-type human transthyretin in complex with sulindac Descriptor: Transthyretin, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid Authors: Lima, L.M.T.R. Deposit date: 2012-12-26 Release date: 2013-01-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of wild-type human transthyretin in complex with sulindac To be Published
6U0Q	Transthyretin in complex with (E)-5,5'-(ethene-1,2-diyl)bis(1,1-dihydroxy-3-oxo-1,3-dihydrobenzo[c][1,2]oxaborol-1-uide) Descriptor: 3-[(~{E})-2-[7,7-bis(oxidanyl)-9-oxidanylidene-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-3-yl]ethenyl]-7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-9-one, Transthyretin Authors: Windsor, I.W, Graham, B.J, Raines, R.T. Deposit date: 2019-08-14 Release date: 2021-01-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Boronic acid with high oxidative stability and utility in biological contexts. Proc.Natl.Acad.Sci.USA, 118, 2021
4IKL	Crystal structure of wild-type human transthyretin in complex with sulindac Descriptor: Transthyretin, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid Authors: Lima, L.M.T.R, Polikarpov, I. Deposit date: 2012-12-26 Release date: 2013-01-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of wild-type human transthyretin in complex with sulindac To be Published
4DET	Crystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE) Descriptor: 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, Transthyretin Authors: Trivella, D.B.B, Polikarpov, I. Deposit date: 2012-01-22 Release date: 2012-11-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
6SUG	Crystal structure of transthyretin in complex with 3-deoxytolcapone, a tolcapone analogue Descriptor: 3-deoxytolcapone, Transthyretin Authors: Loconte, V, Cianci, M, Menozzi, I, Sbravati, D, Sansone, F, Casnati, A, Berni, R. Deposit date: 2019-09-14 Release date: 2020-08-05 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.21 Å) Cite: Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin. Bioorg.Chem., 103, 2020

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