4Q4A
| Improved model of AMP-PNP bound TM287/288 | Descriptor: | ABC transporter, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Hohl, M, Gruetter, M.G, Seeger, M.A. | Deposit date: | 2014-04-14 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter. Proc.Natl.Acad.Sci.USA, 111, 2014
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4Q7K
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4Q7L
| Structure of NBD288 of TM287/288 | Descriptor: | NICKEL (II) ION, Uncharacterized ABC transporter ATP-binding protein TM_0288 | Authors: | Bukowska, M.A, Hohl, M, Gruetter, M.G, Seeger, M.A. | Deposit date: | 2014-04-25 | Release date: | 2015-05-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter. Biochemistry, 54, 2015
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4Q4J
| Structure of crosslinked TM287/288_S498C_S520C mutant | Descriptor: | ABC transporter, Uncharacterized ABC transporter ATP-binding protein TM_0288 | Authors: | Hohl, M, Schoeppe, J, Gruetter, M.G, Seeger, M.A. | Deposit date: | 2014-04-14 | Release date: | 2014-07-16 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter. Proc.Natl.Acad.Sci.USA, 111, 2014
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4Q4H
| TM287/288 in its apo state | Descriptor: | ABC transporter, Uncharacterized ABC transporter ATP-binding protein TM_0288 | Authors: | Hohl, M, Gruetter, M.G, Seeger, M.A. | Deposit date: | 2014-04-14 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.527 Å) | Cite: | Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter. Proc.Natl.Acad.Sci.USA, 111, 2014
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4Q7M
| Structure of NBD288-Avi of TM287/288 | Descriptor: | Uncharacterized ABC transporter ATP-binding protein TM_0288 | Authors: | Bukowska, M.A, Hohl, M, Gruetter, M.G, Seeger, M.A. | Deposit date: | 2014-04-25 | Release date: | 2015-05-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter. Biochemistry, 54, 2015
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4NZV
| DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities | Descriptor: | Exonuclease, putative, MANGANESE (II) ION | Authors: | Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A. | Deposit date: | 2013-12-12 | Release date: | 2014-01-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Mol.Cell, 53, 2014
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4GTA
| T. Maritima FDTS with FAD, dUMP, and Folinic Acid | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Mathews, I.I, Lesley, S.A, Kohen, A. | Deposit date: | 2012-08-28 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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3E57
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4GTB
| T. Maritima FDTS with FAD, dUMP, and Raltitrexed. | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Mathews, I.I, Lesley, S.A, Kohen, A. | Deposit date: | 2012-08-28 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4HHT
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4GTE
| T. Maritima FDTS (E144R mutant) with FAD and Folate | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid, Thymidylate synthase thyX | Authors: | Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A. | Deposit date: | 2012-08-28 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTF
| T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Mathews, I.I, Lesley, S.A, Kohen, A. | Deposit date: | 2012-08-28 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTD
| T. Maritima FDTS (E144R mutant) with FAD and dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | Authors: | Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A. | Deposit date: | 2012-08-28 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTC
| T. Maritima FDTS (E144R mutant) plus FAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | Authors: | Mathews, I.I, Lesley, S.A, Kohen, A, Prabhakar, A. | Deposit date: | 2012-08-28 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GT9
| T. Maritima FDTS with FAD, dUMP and Folate. | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Mathews, I.I, Lesley, S.A, Kohen, A. | Deposit date: | 2012-08-28 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTL
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4I76
| Crystal structure of transcriptional regulator TM1030 with octanol | Descriptor: | 1,2-ETHANEDIOL, OCTAN-1-OL, Transcriptional regulator, ... | Authors: | Koclega, K.D, Chruszcz, M, Cooper, D.R, Petkowski, J.J, Tkaczuk, K.L, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2012-11-30 | Release date: | 2013-01-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of transcriptional regulator TM1030 with octanol To be Published
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4I6Z
| Crystal structure of the transcriptional regulator TM1030 with 24bp DNA oligonucleotide | Descriptor: | DNA OLIGONUCLEOTIDE, Transcriptional regulator, TetR family | Authors: | Koclega, K.D, Chruszcz, M, Cooper, D.R, Petkowski, J.J, Tkaczuk, K.L, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2012-11-30 | Release date: | 2013-01-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the transcriptional regulator TM1030 with 24bp DNA oligonucleotide To be Published
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4KAT
| Crystal structure of FDTS from T. maritima mutant (R174K) with FAD and dUMP | Descriptor: | 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Thymidylate synthase | Authors: | Mathews, I.I. | Deposit date: | 2013-04-22 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef, Suppl 12, 2013
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4J9J
| Structure of designed HisF | Descriptor: | Imidazole glycerol phosphate synthase subunit HisF | Authors: | Sterner, R, Rajendran, C, Sperl, J. | Deposit date: | 2013-02-16 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Establishing catalytic activity on an artificial ( beta alpha )8-barrel protein designed from identical half-barrels. Febs Lett., 587, 2013
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4KAR
| Crystal structure of FDTS (TM0449) mutant (H53D) with FAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NONAETHYLENE GLYCOL, Thymidylate synthase | Authors: | Mathews, I.I. | Deposit date: | 2013-04-22 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef, Suppl 12, 2013
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4KAS
| Crystal structure of FDTS from T. maritima mutant (H53D) with FAD and dUMP | Descriptor: | 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Mathews, I.I. | Deposit date: | 2013-04-22 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef, Suppl 12, 2013
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3N0B
| TM0449 mutant crystals grown in loops/micromounts | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | Authors: | Mathews, I.I. | Deposit date: | 2010-05-13 | Release date: | 2011-05-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Diffraction study of protein crystals grown in cryoloops and micromounts. J.Appl.Crystallogr., 43, 2010
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6YMU
| Imidazole Glycerol Phosphate Synthase | Descriptor: | Imidazole glycerol phosphate synthase subunit HisF, Imidazole glycerol phosphate synthase subunit HisH | Authors: | Sterner, R, Rajendran, C, Andrea, K. | Deposit date: | 2020-04-09 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase. Biochemistry, 59, 2020
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