7YZ9
| Structure of catalytic domain of Rv1625c bound to nanobody NB4 | Descriptor: | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, GLYCEROL, ... | Authors: | Khanppnavar, B, Mehta, V.J, Iype, T, Korkhov, V.M. | Deposit date: | 2022-02-19 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
|
|
6AOA
| |
6AOB
| |
6AO9
| |
1WC1
| Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS | Descriptor: | ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ADENYLATE CYCLASE, MAGNESIUM ION | Authors: | Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. | Deposit date: | 2004-11-06 | Release date: | 2004-12-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
|
|
1WC4
| Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP and Europium | Descriptor: | ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, EUROPIUM (III) ION | Authors: | Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. | Deposit date: | 2004-11-08 | Release date: | 2004-12-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
|
|
1WC0
| Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP | Descriptor: | ADENYLATE CYCLASE, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | Authors: | Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. | Deposit date: | 2004-11-05 | Release date: | 2004-12-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
|
|
4WP3
| |
4WP9
| Crystal structure of Adenylyl cyclase MA1120 from Mycobacterium Avium bound to 2'5'-DD-3'-ATP, Calcium and Magnesium ion | Descriptor: | 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CALCIUM ION, MAGNESIUM ION, ... | Authors: | Bharambe, N.G, Barathy, D.V, Suguna, K. | Deposit date: | 2014-10-17 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.382 Å) | Cite: | Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
|
|
4WPA
| |
4WP8
| Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium in complex with 2'5'-DD-3'-ATP and Manganese ion | Descriptor: | 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CHLORIDE ION, MANGANESE (II) ION, ... | Authors: | Barathy, D.V, Bharambe, N.G, Suguna, K. | Deposit date: | 2014-10-17 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
|
|
8CNH
| |
8COJ
| |
8COT
| |
8B75
| CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861 | Descriptor: | Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol | Authors: | Steegborn, C, Kehr, M. | Deposit date: | 2022-09-28 | Release date: | 2023-03-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J.Med.Chem., 65, 2022
|
|
8CO7
| |
1WC3
| Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP and Strontium | Descriptor: | ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, STRONTIUM ION | Authors: | Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. | Deposit date: | 2004-11-08 | Release date: | 2004-12-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
|
|
1WC5
| Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP in presence of bicarbonate | Descriptor: | ADENYLATE CYCLASE, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. | Deposit date: | 2004-11-08 | Release date: | 2004-12-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
|
|
7OVD
| Human soluble adenylyl cyclase in complex with the inhibitor TDI10229 | Descriptor: | 1,2-ETHANEDIOL, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... | Authors: | Steegborn, C, Quast, J. | Deposit date: | 2021-06-14 | Release date: | 2021-10-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). Acs Med.Chem.Lett., 12, 2021
|
|
1YK9
| Crystal structure of a mutant form of the mycobacterial adenylyl cyclase Rv1625c | Descriptor: | Adenylate cyclase | Authors: | Ketkar, A.D, Shenoy, A.R, Ramagopal, U.A, Visweswariah, S.S, Suguna, K, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-01-17 | Release date: | 2006-01-24 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A Structural Basis for the Role of Nucleotide Specifying Residues in Regulating the Oligomerization of the Rv1625c Adenylyl Cyclase from M.tuberculosis J.Mol.Biol., 356, 2006
|
|
1AB8
| |
7PD4
| |
7PD8
| |
7PDH
| |
7PDD
| |